Whipple disease of the nervous system

John Halperin, Dennis M.D. Landis, George M. Kleinman

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

A 58-year-old man with dizziness and unsteady gait had a 10-year history of behavioral change, impotence, and a progressive peripheral neuropathy. CT revealed low-density, contrast-enhancing lesions in the right pontine tegmentum and the right medial temporal lobe. Temporal lobe biopsy contained a collection of mature histiocytes, with PAS-positive rod-shaped inclusions. These inclusions, when studied by electronmicroscopy, were seen to be membrane-bound bacilliform bodies. Peroral jejunal biopsy contained no such inclusions. Despite treatment with antibiotics, the patient’s neurologic illness progressed, and he succumbed to intercurrent sepsis. We believe this to be the first instance in which a lesion of Whipple disease has been identified within the CNS by CT scan, and the diagnosis made antemortem, in the absence of demonstrable systemic disease.

Original languageEnglish (US)
Pages (from-to)612-617
Number of pages6
JournalNeurology
Volume32
Issue number6
StatePublished - Jan 1 1982
Externally publishedYes

Fingerprint

Whipple Disease
Temporal Lobe
Nervous System
Neurologic Gait Disorders
Biopsy
Histiocytes
Dizziness
Peripheral Nervous System Diseases
Erectile Dysfunction
Sepsis
Anti-Bacterial Agents
Membranes
Therapeutics
Pontine Tegmentum

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Halperin, J., Landis, D. M. D., & Kleinman, G. M. (1982). Whipple disease of the nervous system. Neurology, 32(6), 612-617.
Halperin, John ; Landis, Dennis M.D. ; Kleinman, George M. / Whipple disease of the nervous system. In: Neurology. 1982 ; Vol. 32, No. 6. pp. 612-617.
@article{b132f90395bc4b9d9941683b869d9c06,
title = "Whipple disease of the nervous system",
abstract = "A 58-year-old man with dizziness and unsteady gait had a 10-year history of behavioral change, impotence, and a progressive peripheral neuropathy. CT revealed low-density, contrast-enhancing lesions in the right pontine tegmentum and the right medial temporal lobe. Temporal lobe biopsy contained a collection of mature histiocytes, with PAS-positive rod-shaped inclusions. These inclusions, when studied by electronmicroscopy, were seen to be membrane-bound bacilliform bodies. Peroral jejunal biopsy contained no such inclusions. Despite treatment with antibiotics, the patient’s neurologic illness progressed, and he succumbed to intercurrent sepsis. We believe this to be the first instance in which a lesion of Whipple disease has been identified within the CNS by CT scan, and the diagnosis made antemortem, in the absence of demonstrable systemic disease.",
author = "John Halperin and Landis, {Dennis M.D.} and Kleinman, {George M.}",
year = "1982",
month = "1",
day = "1",
language = "English (US)",
volume = "32",
pages = "612--617",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

Halperin, J, Landis, DMD & Kleinman, GM 1982, 'Whipple disease of the nervous system', Neurology, vol. 32, no. 6, pp. 612-617.

Whipple disease of the nervous system. / Halperin, John; Landis, Dennis M.D.; Kleinman, George M.

In: Neurology, Vol. 32, No. 6, 01.01.1982, p. 612-617.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Whipple disease of the nervous system

AU - Halperin, John

AU - Landis, Dennis M.D.

AU - Kleinman, George M.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - A 58-year-old man with dizziness and unsteady gait had a 10-year history of behavioral change, impotence, and a progressive peripheral neuropathy. CT revealed low-density, contrast-enhancing lesions in the right pontine tegmentum and the right medial temporal lobe. Temporal lobe biopsy contained a collection of mature histiocytes, with PAS-positive rod-shaped inclusions. These inclusions, when studied by electronmicroscopy, were seen to be membrane-bound bacilliform bodies. Peroral jejunal biopsy contained no such inclusions. Despite treatment with antibiotics, the patient’s neurologic illness progressed, and he succumbed to intercurrent sepsis. We believe this to be the first instance in which a lesion of Whipple disease has been identified within the CNS by CT scan, and the diagnosis made antemortem, in the absence of demonstrable systemic disease.

AB - A 58-year-old man with dizziness and unsteady gait had a 10-year history of behavioral change, impotence, and a progressive peripheral neuropathy. CT revealed low-density, contrast-enhancing lesions in the right pontine tegmentum and the right medial temporal lobe. Temporal lobe biopsy contained a collection of mature histiocytes, with PAS-positive rod-shaped inclusions. These inclusions, when studied by electronmicroscopy, were seen to be membrane-bound bacilliform bodies. Peroral jejunal biopsy contained no such inclusions. Despite treatment with antibiotics, the patient’s neurologic illness progressed, and he succumbed to intercurrent sepsis. We believe this to be the first instance in which a lesion of Whipple disease has been identified within the CNS by CT scan, and the diagnosis made antemortem, in the absence of demonstrable systemic disease.

UR - http://www.scopus.com/inward/record.url?scp=0020067674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020067674&partnerID=8YFLogxK

M3 - Article

VL - 32

SP - 612

EP - 617

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 6

ER -

Halperin J, Landis DMD, Kleinman GM. Whipple disease of the nervous system. Neurology. 1982 Jan 1;32(6):612-617.