Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

William P. Sexauer, Anas Hadeh, Pamela A. Ohman-Strickland, Robert L. Zanni, Laurie Varlotta, Douglas Holsclaw, Stanley Fiel, Gavin R. Graff, Arthur Atlas, Dorothy Bisberg, Denis Hadjiliadis, Suzanne H. Michel, Daria Mintz, Rebanta Chakraborty, Bridget Marra, Paula Lomas, Tara Ward, Meagen Sassman, Giovanna C. Imbesi, Diane M. KitchAllison M. Mallowe

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2. months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. Results: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function. Conclusions: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.

Original languageEnglish (US)
Pages (from-to)497-506
Number of pages10
JournalJournal of Cystic Fibrosis
Volume14
Issue number4
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

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Vitamin D Deficiency
Cystic Fibrosis
Lung
Forced Expiratory Volume
Serum
Vital Capacity
Vitamin D
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Sexauer, W. P., Hadeh, A., Ohman-Strickland, P. A., Zanni, R. L., Varlotta, L., Holsclaw, D., ... Mallowe, A. M. (2015). Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis. Journal of Cystic Fibrosis, 14(4), 497-506. https://doi.org/10.1016/j.jcf.2014.12.006
Sexauer, William P. ; Hadeh, Anas ; Ohman-Strickland, Pamela A. ; Zanni, Robert L. ; Varlotta, Laurie ; Holsclaw, Douglas ; Fiel, Stanley ; Graff, Gavin R. ; Atlas, Arthur ; Bisberg, Dorothy ; Hadjiliadis, Denis ; Michel, Suzanne H. ; Mintz, Daria ; Chakraborty, Rebanta ; Marra, Bridget ; Lomas, Paula ; Ward, Tara ; Sassman, Meagen ; Imbesi, Giovanna C. ; Kitch, Diane M. ; Mallowe, Allison M. / Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis. In: Journal of Cystic Fibrosis. 2015 ; Vol. 14, No. 4. pp. 497-506.
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title = "Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis",
abstract = "Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2. months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. Results: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) {\%} predicted (r=0.20, p<0.0001) and forced vital capacity {\%} predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 {\%} predicted even after controlling for multiple other factors known to affect CF lung function. Conclusions: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.",
author = "Sexauer, {William P.} and Anas Hadeh and Ohman-Strickland, {Pamela A.} and Zanni, {Robert L.} and Laurie Varlotta and Douglas Holsclaw and Stanley Fiel and Graff, {Gavin R.} and Arthur Atlas and Dorothy Bisberg and Denis Hadjiliadis and Michel, {Suzanne H.} and Daria Mintz and Rebanta Chakraborty and Bridget Marra and Paula Lomas and Tara Ward and Meagen Sassman and Imbesi, {Giovanna C.} and Kitch, {Diane M.} and Mallowe, {Allison M.}",
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Sexauer, WP, Hadeh, A, Ohman-Strickland, PA, Zanni, RL, Varlotta, L, Holsclaw, D, Fiel, S, Graff, GR, Atlas, A, Bisberg, D, Hadjiliadis, D, Michel, SH, Mintz, D, Chakraborty, R, Marra, B, Lomas, P, Ward, T, Sassman, M, Imbesi, GC, Kitch, DM & Mallowe, AM 2015, 'Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis', Journal of Cystic Fibrosis, vol. 14, no. 4, pp. 497-506. https://doi.org/10.1016/j.jcf.2014.12.006

Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis. / Sexauer, William P.; Hadeh, Anas; Ohman-Strickland, Pamela A.; Zanni, Robert L.; Varlotta, Laurie; Holsclaw, Douglas; Fiel, Stanley; Graff, Gavin R.; Atlas, Arthur; Bisberg, Dorothy; Hadjiliadis, Denis; Michel, Suzanne H.; Mintz, Daria; Chakraborty, Rebanta; Marra, Bridget; Lomas, Paula; Ward, Tara; Sassman, Meagen; Imbesi, Giovanna C.; Kitch, Diane M.; Mallowe, Allison M.

In: Journal of Cystic Fibrosis, Vol. 14, No. 4, 01.07.2015, p. 497-506.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

AU - Sexauer, William P.

AU - Hadeh, Anas

AU - Ohman-Strickland, Pamela A.

AU - Zanni, Robert L.

AU - Varlotta, Laurie

AU - Holsclaw, Douglas

AU - Fiel, Stanley

AU - Graff, Gavin R.

AU - Atlas, Arthur

AU - Bisberg, Dorothy

AU - Hadjiliadis, Denis

AU - Michel, Suzanne H.

AU - Mintz, Daria

AU - Chakraborty, Rebanta

AU - Marra, Bridget

AU - Lomas, Paula

AU - Ward, Tara

AU - Sassman, Meagen

AU - Imbesi, Giovanna C.

AU - Kitch, Diane M.

AU - Mallowe, Allison M.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2. months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. Results: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function. Conclusions: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.

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Sexauer WP, Hadeh A, Ohman-Strickland PA, Zanni RL, Varlotta L, Holsclaw D et al. Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis. Journal of Cystic Fibrosis. 2015 Jul 1;14(4):497-506. https://doi.org/10.1016/j.jcf.2014.12.006