Use of probe-based confocal laser endomicroscopy (pCLE) in gastrointestinal applications. A consensus report based on clinical evidence

Kenneth K. Wang, David L. Carr-Locke, Satish K. Singh, Helmut Neumann, Helga Bertani, Jean Paul Galmiche, Razvan I. Arsenescu, Fabrice Caillol, Kenneth J. Chang, Stanislas Chaussade, Emmanuel Coron, Guido Costamagna, Aldona Dlugosz, S. Ian Gan, Marc Giovannini, Frank G. Gress, Oleh Haluszka, Khek Y. Ho, Michel Kahaleh, Vani J. KondaFrederic Prat, Raj J. Shah, Prateek Sharma, Adam Slivka, Herbert C. Wolfsen, Alvin Zfass

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Probe-based confocal laser endomicroscopy (pCLE) provides microscopic imaging during an endoscopic procedure. Its introduction as a standard modality in gastroenterology has brought significant progress in management strategies, affecting many aspects of clinical care and requiring standardisation of practice and training. Objective: This study aimed to provide guidance on the standardisation of its practice and training in Barrett’s oesophagus, biliary strictures, colorectal lesions and inflammatory bowel diseases. Methods: Initial statements were developed by five group leaders, based on the available clinical evidence. These statements were then voted and edited by the 26 participants, using a modified Delphi approach. After two rounds of votes, statements were validated if the threshold of agreement was higher than 75%. Results: Twenty-six experts participated and, among a total of 77 statements, 61 were adopted (79%) and 16 were rejected (21%). The adoption of each statement was justified by the grade of evidence. Conclusion: pCLE should be used to enhance the diagnostic arsenal in the evaluation of these indications, by providing microscopic information which improves the diagnostic performance of the physician. In order actually to implement this technology in the clinical routine, and to ensure good practice, standardised initial and continuing institutional training programmes should be established.

Original languageEnglish (US)
Pages (from-to)230-254
Number of pages25
JournalUnited European Gastroenterology Journal
Volume3
Issue number3
DOIs
StatePublished - Jan 1 2015

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Lasers
Barrett Esophagus
Gastroenterology
Inflammatory Bowel Diseases
Pathologic Constriction
Technology
Physicians
Education

All Science Journal Classification (ASJC) codes

  • Oncology
  • Gastroenterology

Cite this

Wang, Kenneth K. ; Carr-Locke, David L. ; Singh, Satish K. ; Neumann, Helmut ; Bertani, Helga ; Galmiche, Jean Paul ; Arsenescu, Razvan I. ; Caillol, Fabrice ; Chang, Kenneth J. ; Chaussade, Stanislas ; Coron, Emmanuel ; Costamagna, Guido ; Dlugosz, Aldona ; Gan, S. Ian ; Giovannini, Marc ; Gress, Frank G. ; Haluszka, Oleh ; Ho, Khek Y. ; Kahaleh, Michel ; Konda, Vani J. ; Prat, Frederic ; Shah, Raj J. ; Sharma, Prateek ; Slivka, Adam ; Wolfsen, Herbert C. ; Zfass, Alvin. / Use of probe-based confocal laser endomicroscopy (pCLE) in gastrointestinal applications. A consensus report based on clinical evidence. In: United European Gastroenterology Journal. 2015 ; Vol. 3, No. 3. pp. 230-254.
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abstract = "Background: Probe-based confocal laser endomicroscopy (pCLE) provides microscopic imaging during an endoscopic procedure. Its introduction as a standard modality in gastroenterology has brought significant progress in management strategies, affecting many aspects of clinical care and requiring standardisation of practice and training. Objective: This study aimed to provide guidance on the standardisation of its practice and training in Barrett’s oesophagus, biliary strictures, colorectal lesions and inflammatory bowel diseases. Methods: Initial statements were developed by five group leaders, based on the available clinical evidence. These statements were then voted and edited by the 26 participants, using a modified Delphi approach. After two rounds of votes, statements were validated if the threshold of agreement was higher than 75{\%}. Results: Twenty-six experts participated and, among a total of 77 statements, 61 were adopted (79{\%}) and 16 were rejected (21{\%}). The adoption of each statement was justified by the grade of evidence. Conclusion: pCLE should be used to enhance the diagnostic arsenal in the evaluation of these indications, by providing microscopic information which improves the diagnostic performance of the physician. In order actually to implement this technology in the clinical routine, and to ensure good practice, standardised initial and continuing institutional training programmes should be established.",
author = "Wang, {Kenneth K.} and Carr-Locke, {David L.} and Singh, {Satish K.} and Helmut Neumann and Helga Bertani and Galmiche, {Jean Paul} and Arsenescu, {Razvan I.} and Fabrice Caillol and Chang, {Kenneth J.} and Stanislas Chaussade and Emmanuel Coron and Guido Costamagna and Aldona Dlugosz and Gan, {S. Ian} and Marc Giovannini and Gress, {Frank G.} and Oleh Haluszka and Ho, {Khek Y.} and Michel Kahaleh and Konda, {Vani J.} and Frederic Prat and Shah, {Raj J.} and Prateek Sharma and Adam Slivka and Wolfsen, {Herbert C.} and Alvin Zfass",
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Wang, KK, Carr-Locke, DL, Singh, SK, Neumann, H, Bertani, H, Galmiche, JP, Arsenescu, RI, Caillol, F, Chang, KJ, Chaussade, S, Coron, E, Costamagna, G, Dlugosz, A, Gan, SI, Giovannini, M, Gress, FG, Haluszka, O, Ho, KY, Kahaleh, M, Konda, VJ, Prat, F, Shah, RJ, Sharma, P, Slivka, A, Wolfsen, HC & Zfass, A 2015, 'Use of probe-based confocal laser endomicroscopy (pCLE) in gastrointestinal applications. A consensus report based on clinical evidence', United European Gastroenterology Journal, vol. 3, no. 3, pp. 230-254. https://doi.org/10.1177/2050640614566066

Use of probe-based confocal laser endomicroscopy (pCLE) in gastrointestinal applications. A consensus report based on clinical evidence. / Wang, Kenneth K.; Carr-Locke, David L.; Singh, Satish K.; Neumann, Helmut; Bertani, Helga; Galmiche, Jean Paul; Arsenescu, Razvan I.; Caillol, Fabrice; Chang, Kenneth J.; Chaussade, Stanislas; Coron, Emmanuel; Costamagna, Guido; Dlugosz, Aldona; Gan, S. Ian; Giovannini, Marc; Gress, Frank G.; Haluszka, Oleh; Ho, Khek Y.; Kahaleh, Michel; Konda, Vani J.; Prat, Frederic; Shah, Raj J.; Sharma, Prateek; Slivka, Adam; Wolfsen, Herbert C.; Zfass, Alvin.

In: United European Gastroenterology Journal, Vol. 3, No. 3, 01.01.2015, p. 230-254.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Use of probe-based confocal laser endomicroscopy (pCLE) in gastrointestinal applications. A consensus report based on clinical evidence

AU - Wang, Kenneth K.

AU - Carr-Locke, David L.

AU - Singh, Satish K.

AU - Neumann, Helmut

AU - Bertani, Helga

AU - Galmiche, Jean Paul

AU - Arsenescu, Razvan I.

AU - Caillol, Fabrice

AU - Chang, Kenneth J.

AU - Chaussade, Stanislas

AU - Coron, Emmanuel

AU - Costamagna, Guido

AU - Dlugosz, Aldona

AU - Gan, S. Ian

AU - Giovannini, Marc

AU - Gress, Frank G.

AU - Haluszka, Oleh

AU - Ho, Khek Y.

AU - Kahaleh, Michel

AU - Konda, Vani J.

AU - Prat, Frederic

AU - Shah, Raj J.

AU - Sharma, Prateek

AU - Slivka, Adam

AU - Wolfsen, Herbert C.

AU - Zfass, Alvin

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: Probe-based confocal laser endomicroscopy (pCLE) provides microscopic imaging during an endoscopic procedure. Its introduction as a standard modality in gastroenterology has brought significant progress in management strategies, affecting many aspects of clinical care and requiring standardisation of practice and training. Objective: This study aimed to provide guidance on the standardisation of its practice and training in Barrett’s oesophagus, biliary strictures, colorectal lesions and inflammatory bowel diseases. Methods: Initial statements were developed by five group leaders, based on the available clinical evidence. These statements were then voted and edited by the 26 participants, using a modified Delphi approach. After two rounds of votes, statements were validated if the threshold of agreement was higher than 75%. Results: Twenty-six experts participated and, among a total of 77 statements, 61 were adopted (79%) and 16 were rejected (21%). The adoption of each statement was justified by the grade of evidence. Conclusion: pCLE should be used to enhance the diagnostic arsenal in the evaluation of these indications, by providing microscopic information which improves the diagnostic performance of the physician. In order actually to implement this technology in the clinical routine, and to ensure good practice, standardised initial and continuing institutional training programmes should be established.

AB - Background: Probe-based confocal laser endomicroscopy (pCLE) provides microscopic imaging during an endoscopic procedure. Its introduction as a standard modality in gastroenterology has brought significant progress in management strategies, affecting many aspects of clinical care and requiring standardisation of practice and training. Objective: This study aimed to provide guidance on the standardisation of its practice and training in Barrett’s oesophagus, biliary strictures, colorectal lesions and inflammatory bowel diseases. Methods: Initial statements were developed by five group leaders, based on the available clinical evidence. These statements were then voted and edited by the 26 participants, using a modified Delphi approach. After two rounds of votes, statements were validated if the threshold of agreement was higher than 75%. Results: Twenty-six experts participated and, among a total of 77 statements, 61 were adopted (79%) and 16 were rejected (21%). The adoption of each statement was justified by the grade of evidence. Conclusion: pCLE should be used to enhance the diagnostic arsenal in the evaluation of these indications, by providing microscopic information which improves the diagnostic performance of the physician. In order actually to implement this technology in the clinical routine, and to ensure good practice, standardised initial and continuing institutional training programmes should be established.

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