Update on primary head and neck mucosal melanoma

Fernando Lõpez, Juan P. Rodrigo, Antonio Cardesa, Asterios Triantafyllou, Kenneth O. Devaney, William M. Mendenhall, Missak Haigentz, Primož Strojan, Phillip K. Pellitteri, Carol R. Bradford, Ashok R. Shaha, Jennifer L. Hunt, Remco De Bree, Robert P. Takes, Alessandra Rinaldo, Alfio Ferlito

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Primary mucosal melanomas (PMMs) of the head and neck are uncommon malignancies that arise mainly in the nasal cavity and paranasal sinuses, followed by the oral cavity. The mainstay of treatment is radical surgical resection followed by adjuvant radiotherapy in selected patients with high-risk features. Multimodality therapy has not been well studied and is not standardized. Adjuvant radiotherapy seems to improve locoregional control but does not improve overall survival (OS). Elective neck dissection is advocated in patients with oral PMM. Systemic therapy should be considered only for patients with metastatic or unresectable locoregional disease. Despite improvements in the field of surgery, radiotherapy, and systemic therapy, patients with PMM still face a very unfavorable prognosis (5-year disease-free survival [DFS] <20%) with high rates of locoregional recurrence and distant metastasis. The present review aims to summarize the current state of knowledge on the molecular biology, pathological diagnosis, and management of this disease.

Original languageEnglish (US)
Pages (from-to)147-155
Number of pages9
JournalHead and Neck
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

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Melanoma
Neck
Head
Adjuvant Radiotherapy
Paranasal Sinuses
Neck Dissection
Nasal Cavity
Therapeutics
Disease Management
Disease-Free Survival
Mouth
Molecular Biology
Radiotherapy
Neoplasm Metastasis
Recurrence
Survival
Neoplasms

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Lõpez, F., Rodrigo, J. P., Cardesa, A., Triantafyllou, A., Devaney, K. O., Mendenhall, W. M., ... Ferlito, A. (2016). Update on primary head and neck mucosal melanoma. Head and Neck, 38(1), 147-155. https://doi.org/10.1002/hed.23872
Lõpez, Fernando ; Rodrigo, Juan P. ; Cardesa, Antonio ; Triantafyllou, Asterios ; Devaney, Kenneth O. ; Mendenhall, William M. ; Haigentz, Missak ; Strojan, Primož ; Pellitteri, Phillip K. ; Bradford, Carol R. ; Shaha, Ashok R. ; Hunt, Jennifer L. ; De Bree, Remco ; Takes, Robert P. ; Rinaldo, Alessandra ; Ferlito, Alfio. / Update on primary head and neck mucosal melanoma. In: Head and Neck. 2016 ; Vol. 38, No. 1. pp. 147-155.
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Lõpez, F, Rodrigo, JP, Cardesa, A, Triantafyllou, A, Devaney, KO, Mendenhall, WM, Haigentz, M, Strojan, P, Pellitteri, PK, Bradford, CR, Shaha, AR, Hunt, JL, De Bree, R, Takes, RP, Rinaldo, A & Ferlito, A 2016, 'Update on primary head and neck mucosal melanoma', Head and Neck, vol. 38, no. 1, pp. 147-155. https://doi.org/10.1002/hed.23872

Update on primary head and neck mucosal melanoma. / Lõpez, Fernando; Rodrigo, Juan P.; Cardesa, Antonio; Triantafyllou, Asterios; Devaney, Kenneth O.; Mendenhall, William M.; Haigentz, Missak; Strojan, Primož; Pellitteri, Phillip K.; Bradford, Carol R.; Shaha, Ashok R.; Hunt, Jennifer L.; De Bree, Remco; Takes, Robert P.; Rinaldo, Alessandra; Ferlito, Alfio.

In: Head and Neck, Vol. 38, No. 1, 01.01.2016, p. 147-155.

Research output: Contribution to journalArticle

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AU - Rodrigo, Juan P.

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AU - Mendenhall, William M.

AU - Haigentz, Missak

AU - Strojan, Primož

AU - Pellitteri, Phillip K.

AU - Bradford, Carol R.

AU - Shaha, Ashok R.

AU - Hunt, Jennifer L.

AU - De Bree, Remco

AU - Takes, Robert P.

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

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Lõpez F, Rodrigo JP, Cardesa A, Triantafyllou A, Devaney KO, Mendenhall WM et al. Update on primary head and neck mucosal melanoma. Head and Neck. 2016 Jan 1;38(1):147-155. https://doi.org/10.1002/hed.23872