Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers

Missak Haigentz, Carlos Suarez, Primoz Strojan, Juan P. Rodrigo, Alessandra Rinaldo, Carol R. Bradford, June Corry, Robert P. Takes, Alfio Ferlito

Research output: Contribution to journalComment/debate

5 Citations (Scopus)

Abstract

The new 8th edition AJCC/UICC staging system for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), developed to account for improved survival outcomes over HPV-negative cancers, includes anatomic features strictly associated with tumor-node-metastasis (TNM) and does not account for patient-specific characteristics that may impact prognosis. This commentary evaluates the evidence of smoking as an adverse prognostic factor in HPV-associated OPSCC. We review the multifactorial biological, clinical, and social/behavioral characteristics of smokers with OPSCC that impact outcomes, discuss current challenges with incorporating smoking history in prognostic classifications, and consider opportunities for future investigation.

Original languageEnglish (US)
Pages (from-to)255-260
Number of pages6
JournalAdvances in Therapy
Volume35
Issue number3
DOIs
StatePublished - Mar 1 2018
Externally publishedYes

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Oropharyngeal Neoplasms
Squamous Cell Carcinoma
Smoking
Neoplasms
History
Neoplasm Metastasis
Survival

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

Haigentz, M., Suarez, C., Strojan, P., Rodrigo, J. P., Rinaldo, A., Bradford, C. R., ... Ferlito, A. (2018). Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers. Advances in Therapy, 35(3), 255-260. https://doi.org/10.1007/s12325-018-0682-4
Haigentz, Missak ; Suarez, Carlos ; Strojan, Primoz ; Rodrigo, Juan P. ; Rinaldo, Alessandra ; Bradford, Carol R. ; Corry, June ; Takes, Robert P. ; Ferlito, Alfio. / Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers. In: Advances in Therapy. 2018 ; Vol. 35, No. 3. pp. 255-260.
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Haigentz, M, Suarez, C, Strojan, P, Rodrigo, JP, Rinaldo, A, Bradford, CR, Corry, J, Takes, RP & Ferlito, A 2018, 'Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers', Advances in Therapy, vol. 35, no. 3, pp. 255-260. https://doi.org/10.1007/s12325-018-0682-4

Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers. / Haigentz, Missak; Suarez, Carlos; Strojan, Primoz; Rodrigo, Juan P.; Rinaldo, Alessandra; Bradford, Carol R.; Corry, June; Takes, Robert P.; Ferlito, Alfio.

In: Advances in Therapy, Vol. 35, No. 3, 01.03.2018, p. 255-260.

Research output: Contribution to journalComment/debate

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T1 - Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers

AU - Haigentz, Missak

AU - Suarez, Carlos

AU - Strojan, Primoz

AU - Rodrigo, Juan P.

AU - Rinaldo, Alessandra

AU - Bradford, Carol R.

AU - Corry, June

AU - Takes, Robert P.

AU - Ferlito, Alfio

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