Treatment trials for post-lyme disease symptoms revisited

Mark S. Klempner, Phillip J. Baker, Eugene D. Shapiro, Adriana Marques, Raymond J. Dattwyler, John J. Halperin, Gary P. Wormser

Research output: Contribution to journalReview article

60 Citations (Scopus)

Abstract

The authors of 4 National Institutes of Health-sponsored antibiotic treatment trials of patients with persistent unexplained symptoms despite previous antibiotic treatment of Lyme disease determined that retreatment provides little if any benefit and carries significant risk. Two groups recently provided an independent reassessment of these trials and concluded that prolonged courses of antibiotics are likely to be helpful. We have carefully considered the points raised by these groups, along with our own critical review of the treatment trials. On the basis of this analysis, the conclusion that there is a meaningful clinical benefit to be gained from retreatment of such patients with parenteral antibiotic therapy cannot be justified.

Original languageEnglish (US)
Pages (from-to)665-669
Number of pages5
JournalAmerican Journal of Medicine
Volume126
Issue number8
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

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Lyme Disease
Anti-Bacterial Agents
Retreatment
National Institutes of Health (U.S.)
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Klempner, M. S., Baker, P. J., Shapiro, E. D., Marques, A., Dattwyler, R. J., Halperin, J. J., & Wormser, G. P. (2013). Treatment trials for post-lyme disease symptoms revisited. American Journal of Medicine, 126(8), 665-669. https://doi.org/10.1016/j.amjmed.2013.02.014
Klempner, Mark S. ; Baker, Phillip J. ; Shapiro, Eugene D. ; Marques, Adriana ; Dattwyler, Raymond J. ; Halperin, John J. ; Wormser, Gary P. / Treatment trials for post-lyme disease symptoms revisited. In: American Journal of Medicine. 2013 ; Vol. 126, No. 8. pp. 665-669.
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Klempner, MS, Baker, PJ, Shapiro, ED, Marques, A, Dattwyler, RJ, Halperin, JJ & Wormser, GP 2013, 'Treatment trials for post-lyme disease symptoms revisited', American Journal of Medicine, vol. 126, no. 8, pp. 665-669. https://doi.org/10.1016/j.amjmed.2013.02.014

Treatment trials for post-lyme disease symptoms revisited. / Klempner, Mark S.; Baker, Phillip J.; Shapiro, Eugene D.; Marques, Adriana; Dattwyler, Raymond J.; Halperin, John J.; Wormser, Gary P.

In: American Journal of Medicine, Vol. 126, No. 8, 01.08.2013, p. 665-669.

Research output: Contribution to journalReview article

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Klempner MS, Baker PJ, Shapiro ED, Marques A, Dattwyler RJ, Halperin JJ et al. Treatment trials for post-lyme disease symptoms revisited. American Journal of Medicine. 2013 Aug 1;126(8):665-669. https://doi.org/10.1016/j.amjmed.2013.02.014