Treatment of a glioblastoma multiforme dural metastasis with stereotactic radiosurgery: A case report and select review of the literature

Lauren L. Hintenlang, Daniel H. Miller, Tasneem Kaleem, Neema Patel, Byron C. May, Katherine S. Tzou, Laura A. Vallow, Steven J. Buskirk, Robert C. Miller, Stephen J. Ko, Kurt Jaeckle, Daniel M. Trifiletti, Jennifer L. Peterson

Research output: Contribution to journalArticle

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Abstract

Glioblastoma multiforme (GBM) is a primary brain neoplasm accounting for approximately 75% of all high grade gliomas. It is diffusely infiltrative and exhibits rapid proliferation with a poor overall prognosis. Maximum surgical resection and postoperative radiotherapy, accompanied by concurrent and adjuvant temozolomide chemotherapy, remain the standard of care without major therapeutic advances over the past 10 years. Herein, we present the case of a 64-year-old Caucasian male with a GBM who subsequently developed a left frontal dural metastasis, subsequently treated with stereotactic radiosurgery (20 Gy in 1 fraction). With six month follow-up, the patient showed near complete resolution of his dural metastases and no overall change in neurological symptoms or side effects following radiosurgery. Due to the paucity of clinical literature regarding dural metastases from GBM, its optimal treatment remains unknown. While the role of SRS has yet to be defined in this setting, here we provide evidence suggesting its overall efficacy in the treatment of select dural GBM metastases.

Original languageEnglish (US)
Pages (from-to)118-121
Number of pages4
JournalJournal of Clinical Neuroscience
Volume48
DOIs
StatePublished - Feb 1 2018

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Radiosurgery
Glioblastoma
Neoplasm Metastasis
temozolomide
Therapeutics
Adjuvant Chemotherapy
Standard of Care
Brain Neoplasms
Glioma
Radiotherapy

All Science Journal Classification (ASJC) codes

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Hintenlang, Lauren L. ; Miller, Daniel H. ; Kaleem, Tasneem ; Patel, Neema ; May, Byron C. ; Tzou, Katherine S. ; Vallow, Laura A. ; Buskirk, Steven J. ; Miller, Robert C. ; Ko, Stephen J. ; Jaeckle, Kurt ; Trifiletti, Daniel M. ; Peterson, Jennifer L. / Treatment of a glioblastoma multiforme dural metastasis with stereotactic radiosurgery : A case report and select review of the literature. In: Journal of Clinical Neuroscience. 2018 ; Vol. 48. pp. 118-121.
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abstract = "Glioblastoma multiforme (GBM) is a primary brain neoplasm accounting for approximately 75{\%} of all high grade gliomas. It is diffusely infiltrative and exhibits rapid proliferation with a poor overall prognosis. Maximum surgical resection and postoperative radiotherapy, accompanied by concurrent and adjuvant temozolomide chemotherapy, remain the standard of care without major therapeutic advances over the past 10 years. Herein, we present the case of a 64-year-old Caucasian male with a GBM who subsequently developed a left frontal dural metastasis, subsequently treated with stereotactic radiosurgery (20 Gy in 1 fraction). With six month follow-up, the patient showed near complete resolution of his dural metastases and no overall change in neurological symptoms or side effects following radiosurgery. Due to the paucity of clinical literature regarding dural metastases from GBM, its optimal treatment remains unknown. While the role of SRS has yet to be defined in this setting, here we provide evidence suggesting its overall efficacy in the treatment of select dural GBM metastases.",
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Hintenlang, LL, Miller, DH, Kaleem, T, Patel, N, May, BC, Tzou, KS, Vallow, LA, Buskirk, SJ, Miller, RC, Ko, SJ, Jaeckle, K, Trifiletti, DM & Peterson, JL 2018, 'Treatment of a glioblastoma multiforme dural metastasis with stereotactic radiosurgery: A case report and select review of the literature', Journal of Clinical Neuroscience, vol. 48, pp. 118-121. https://doi.org/10.1016/j.jocn.2017.11.003

Treatment of a glioblastoma multiforme dural metastasis with stereotactic radiosurgery : A case report and select review of the literature. / Hintenlang, Lauren L.; Miller, Daniel H.; Kaleem, Tasneem; Patel, Neema; May, Byron C.; Tzou, Katherine S.; Vallow, Laura A.; Buskirk, Steven J.; Miller, Robert C.; Ko, Stephen J.; Jaeckle, Kurt; Trifiletti, Daniel M.; Peterson, Jennifer L.

In: Journal of Clinical Neuroscience, Vol. 48, 01.02.2018, p. 118-121.

Research output: Contribution to journalArticle

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T1 - Treatment of a glioblastoma multiforme dural metastasis with stereotactic radiosurgery

T2 - A case report and select review of the literature

AU - Hintenlang, Lauren L.

AU - Miller, Daniel H.

AU - Kaleem, Tasneem

AU - Patel, Neema

AU - May, Byron C.

AU - Tzou, Katherine S.

AU - Vallow, Laura A.

AU - Buskirk, Steven J.

AU - Miller, Robert C.

AU - Ko, Stephen J.

AU - Jaeckle, Kurt

AU - Trifiletti, Daniel M.

AU - Peterson, Jennifer L.

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N2 - Glioblastoma multiforme (GBM) is a primary brain neoplasm accounting for approximately 75% of all high grade gliomas. It is diffusely infiltrative and exhibits rapid proliferation with a poor overall prognosis. Maximum surgical resection and postoperative radiotherapy, accompanied by concurrent and adjuvant temozolomide chemotherapy, remain the standard of care without major therapeutic advances over the past 10 years. Herein, we present the case of a 64-year-old Caucasian male with a GBM who subsequently developed a left frontal dural metastasis, subsequently treated with stereotactic radiosurgery (20 Gy in 1 fraction). With six month follow-up, the patient showed near complete resolution of his dural metastases and no overall change in neurological symptoms or side effects following radiosurgery. Due to the paucity of clinical literature regarding dural metastases from GBM, its optimal treatment remains unknown. While the role of SRS has yet to be defined in this setting, here we provide evidence suggesting its overall efficacy in the treatment of select dural GBM metastases.

AB - Glioblastoma multiforme (GBM) is a primary brain neoplasm accounting for approximately 75% of all high grade gliomas. It is diffusely infiltrative and exhibits rapid proliferation with a poor overall prognosis. Maximum surgical resection and postoperative radiotherapy, accompanied by concurrent and adjuvant temozolomide chemotherapy, remain the standard of care without major therapeutic advances over the past 10 years. Herein, we present the case of a 64-year-old Caucasian male with a GBM who subsequently developed a left frontal dural metastasis, subsequently treated with stereotactic radiosurgery (20 Gy in 1 fraction). With six month follow-up, the patient showed near complete resolution of his dural metastases and no overall change in neurological symptoms or side effects following radiosurgery. Due to the paucity of clinical literature regarding dural metastases from GBM, its optimal treatment remains unknown. While the role of SRS has yet to be defined in this setting, here we provide evidence suggesting its overall efficacy in the treatment of select dural GBM metastases.

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