Topical agents in the treatment of rheumatic disorders

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Topical drug delivery may be the optimal route for the treatment of localized musculoskeletal disorders because higher drug concentrations can be achieved at the sites of clinical significance. The rationale for the use of topical salicylates and other nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of soft-tissue rheumatic complaints and osteoarthritis is reviewed. Topical capsaicin offers another potentially beneficial therapy for the treatment of osteoarthritis of selected joints. Although there are extensive, uncontrolled experiences with DMSO that suggests its effectiveness in the treatment of musculoskeletal disorders, controlled trials yield conflicting results. The basis for the use of physical modalities such as phonophoresis and iontophoresis to improve topical drug efficacy is summarized.

Original languageEnglish (US)
Pages (from-to)899-918
Number of pages20
JournalRheumatic Disease Clinics of North America
Volume25
Issue number4
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

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Osteoarthritis
Pharmaceutical Preparations
Phonophoresis
Iontophoresis
Salicylates
Capsaicin
Therapeutics
Dimethyl Sulfoxide
Anti-Inflammatory Agents
Joints

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

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Topical agents in the treatment of rheumatic disorders. / Rosenstein, Elliot.

In: Rheumatic Disease Clinics of North America, Vol. 25, No. 4, 01.01.1999, p. 899-918.

Research output: Contribution to journalArticle

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