The influence of race on the incidence of respiratory distress syndrome after antenatal betamethasone or dexamethasone

Keisha Y. Dyer, Jesus R. Alvarez, Charbel G. Salamon, Joseph J. Apuzzio, Manuel Alvarez, Abdulla Al-Khan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVE: To compare the incidence of respiratory distress syndrome (RDS) in African American and Caucasian neonates after antenatal betamethasone or dexamethasone. STUDY DESIGN: This was a retrospective review of all deliveries occurring at ≤32 weeks' gestation at Hackensack University Medical Center from 2001 to 2004. Only patients who received a complete course of antenatal steroids were included. The type (betamethasone or dexamethasone) was based on pharmacy supply. Statistical analysis was performed using Pearson's χ 2 and Fisher's exact test. RESULTS: The African American (n=32) and Caucasian (n = 86) groups were similar in terms of maternal age, gestational age and infant birth weight. African Americans receiving dexamethasone had a 1.65-fold increased risk of delivering infants with RDS as compared to those who received betamethasone (91.3% vs. 55.6%, respectively; p = 0.038). No difference was noted among Caucasians. CONCLUSION: Among African American neonates, the incidence of RDS was higher in those who received dexamethasone vs. betamethasone.

Original languageEnglish (US)
Pages (from-to)124-128
Number of pages5
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume55
Issue number3-4
StatePublished - Mar 1 2010

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Betamethasone
African Americans
Dexamethasone
Incidence
Newborn Infant
Newborn Respiratory Distress Syndrome
Maternal Age
Birth Weight
Gestational Age
Steroids
Pregnancy

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Dyer, Keisha Y. ; Alvarez, Jesus R. ; Salamon, Charbel G. ; Apuzzio, Joseph J. ; Alvarez, Manuel ; Al-Khan, Abdulla. / The influence of race on the incidence of respiratory distress syndrome after antenatal betamethasone or dexamethasone. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 2010 ; Vol. 55, No. 3-4. pp. 124-128.
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The influence of race on the incidence of respiratory distress syndrome after antenatal betamethasone or dexamethasone. / Dyer, Keisha Y.; Alvarez, Jesus R.; Salamon, Charbel G.; Apuzzio, Joseph J.; Alvarez, Manuel; Al-Khan, Abdulla.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 55, No. 3-4, 01.03.2010, p. 124-128.

Research output: Contribution to journalArticle

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AB - OBJECTIVE: To compare the incidence of respiratory distress syndrome (RDS) in African American and Caucasian neonates after antenatal betamethasone or dexamethasone. STUDY DESIGN: This was a retrospective review of all deliveries occurring at ≤32 weeks' gestation at Hackensack University Medical Center from 2001 to 2004. Only patients who received a complete course of antenatal steroids were included. The type (betamethasone or dexamethasone) was based on pharmacy supply. Statistical analysis was performed using Pearson's χ 2 and Fisher's exact test. RESULTS: The African American (n=32) and Caucasian (n = 86) groups were similar in terms of maternal age, gestational age and infant birth weight. African Americans receiving dexamethasone had a 1.65-fold increased risk of delivering infants with RDS as compared to those who received betamethasone (91.3% vs. 55.6%, respectively; p = 0.038). No difference was noted among Caucasians. CONCLUSION: Among African American neonates, the incidence of RDS was higher in those who received dexamethasone vs. betamethasone.

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