The effect of enteral feedings supplemented with pectin on the healing of colonic anastomoses in the rat

Rolando Rolandelli, Mark J. Koruda, R. Gregg Settle, John L. Rombeau

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The effect of the addition of pectin to an elemental diet on the healing of experimental colonic anastomoses was investigated. Transection and anastomosis of the ascending colon and feeding gastrostomy were performed in 24 Sprague-Dawley rats. All rats then received an elemental diet, and 12 of them had 1% ( w v) citrus pectin added to their diet. On the seventh postoperative day, animals that received pectin-supplemented diets had significantly greater bursting pressures at the anastomoses (266 versus 234 mm Hg, p < 0.04) and significantly lower colonic mucosal pH (6.2 versus 6.8, p < 0.001) than animals that received the elemental diet only. The colons from animals fed pectin also had significantly higher hydroxyproline content at the anastomosis than those of the control animals (46.6 versus 40.7 μg hydroxyproline nitrogen/mg tissue nitrogen, p < 0.05). The decreased intracolonic pH is consistent with the hypothesis that improved healing is a local effect mediated by the presence of short-chain fatty acids resulting from the fermentation of pectin.

Original languageEnglish (US)
Pages (from-to)703-707
Number of pages5
JournalSurgery
Volume99
Issue number6
StatePublished - Jan 1 1986
Externally publishedYes

Fingerprint

Enteral Nutrition
Formulated Food
Hydroxyproline
Nitrogen
Diet
Ascending Colon
Gastrostomy
Volatile Fatty Acids
Fermentation
Sprague Dawley Rats
Colon
Pressure
pectin

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Rolandelli, Rolando ; Koruda, Mark J. ; Settle, R. Gregg ; Rombeau, John L. / The effect of enteral feedings supplemented with pectin on the healing of colonic anastomoses in the rat. In: Surgery. 1986 ; Vol. 99, No. 6. pp. 703-707.
@article{cd4ebb946fec4512ac4e8e447ff42696,
title = "The effect of enteral feedings supplemented with pectin on the healing of colonic anastomoses in the rat",
abstract = "The effect of the addition of pectin to an elemental diet on the healing of experimental colonic anastomoses was investigated. Transection and anastomosis of the ascending colon and feeding gastrostomy were performed in 24 Sprague-Dawley rats. All rats then received an elemental diet, and 12 of them had 1{\%} ( w v) citrus pectin added to their diet. On the seventh postoperative day, animals that received pectin-supplemented diets had significantly greater bursting pressures at the anastomoses (266 versus 234 mm Hg, p < 0.04) and significantly lower colonic mucosal pH (6.2 versus 6.8, p < 0.001) than animals that received the elemental diet only. The colons from animals fed pectin also had significantly higher hydroxyproline content at the anastomosis than those of the control animals (46.6 versus 40.7 μg hydroxyproline nitrogen/mg tissue nitrogen, p < 0.05). The decreased intracolonic pH is consistent with the hypothesis that improved healing is a local effect mediated by the presence of short-chain fatty acids resulting from the fermentation of pectin.",
author = "Rolando Rolandelli and Koruda, {Mark J.} and Settle, {R. Gregg} and Rombeau, {John L.}",
year = "1986",
month = "1",
day = "1",
language = "English (US)",
volume = "99",
pages = "703--707",
journal = "Surgery",
issn = "0039-6060",
publisher = "Mosby Inc.",
number = "6",

}

The effect of enteral feedings supplemented with pectin on the healing of colonic anastomoses in the rat. / Rolandelli, Rolando; Koruda, Mark J.; Settle, R. Gregg; Rombeau, John L.

In: Surgery, Vol. 99, No. 6, 01.01.1986, p. 703-707.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of enteral feedings supplemented with pectin on the healing of colonic anastomoses in the rat

AU - Rolandelli, Rolando

AU - Koruda, Mark J.

AU - Settle, R. Gregg

AU - Rombeau, John L.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - The effect of the addition of pectin to an elemental diet on the healing of experimental colonic anastomoses was investigated. Transection and anastomosis of the ascending colon and feeding gastrostomy were performed in 24 Sprague-Dawley rats. All rats then received an elemental diet, and 12 of them had 1% ( w v) citrus pectin added to their diet. On the seventh postoperative day, animals that received pectin-supplemented diets had significantly greater bursting pressures at the anastomoses (266 versus 234 mm Hg, p < 0.04) and significantly lower colonic mucosal pH (6.2 versus 6.8, p < 0.001) than animals that received the elemental diet only. The colons from animals fed pectin also had significantly higher hydroxyproline content at the anastomosis than those of the control animals (46.6 versus 40.7 μg hydroxyproline nitrogen/mg tissue nitrogen, p < 0.05). The decreased intracolonic pH is consistent with the hypothesis that improved healing is a local effect mediated by the presence of short-chain fatty acids resulting from the fermentation of pectin.

AB - The effect of the addition of pectin to an elemental diet on the healing of experimental colonic anastomoses was investigated. Transection and anastomosis of the ascending colon and feeding gastrostomy were performed in 24 Sprague-Dawley rats. All rats then received an elemental diet, and 12 of them had 1% ( w v) citrus pectin added to their diet. On the seventh postoperative day, animals that received pectin-supplemented diets had significantly greater bursting pressures at the anastomoses (266 versus 234 mm Hg, p < 0.04) and significantly lower colonic mucosal pH (6.2 versus 6.8, p < 0.001) than animals that received the elemental diet only. The colons from animals fed pectin also had significantly higher hydroxyproline content at the anastomosis than those of the control animals (46.6 versus 40.7 μg hydroxyproline nitrogen/mg tissue nitrogen, p < 0.05). The decreased intracolonic pH is consistent with the hypothesis that improved healing is a local effect mediated by the presence of short-chain fatty acids resulting from the fermentation of pectin.

UR - http://www.scopus.com/inward/record.url?scp=0022544195&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022544195&partnerID=8YFLogxK

M3 - Article

C2 - 3086994

AN - SCOPUS:0022544195

VL - 99

SP - 703

EP - 707

JO - Surgery

JF - Surgery

SN - 0039-6060

IS - 6

ER -