Surgical implications of Helicobacter pylori infection.

K. O. Clarke, Lawrence Harrison

Research output: Contribution to journalReview article

Abstract

Helicobacter pylori infection is the most common cause of peptic ulcer disease and is an etiologic factor in the development of gastric malignancies. Eradication of H. pylori heals most uncomplicated peptic ulcers, as well as preventing their relapse. In addition, H. pylori therapy has recently been used as a first line treatment for most low grade MALT lymphomas. Despite its efficacy, a small percentage of patients with peptic ulcer disease will require operative intervention and the indications for surgical intervention for the patient with peptic ulcer disease include; intractability, gastric outlet obstruction, acute perforation, and bleeding uncontrolled by endoscopic intervention. H. pylori has also been shown to be associated with an increased risk of gastric adenocarcinoma and surgical exploration may play a role in diagnosis, staging and treatment. Finally, the relationship between H. pylori infection and the development of gastric MALT lymphoma is well established. While treatment for H. pylori infection is indicated for low grade MALT lymphomas, surgical resection may be indicated for treatment failures, as well as for certain high grade lesions.

Original languageEnglish (US)
JournalFrontiers in bioscience : a journal and virtual library
Volume6
StatePublished - Jan 1 2001

Fingerprint

Helicobacter Infections
Helicobacter pylori
Peptic Ulcer
Marginal Zone B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Stomach
Gastric Outlet Obstruction
Therapeutics
Treatment Failure
Adenocarcinoma
Hemorrhage
Recurrence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

@article{e77e8d076e9a45d483771fc4ade092ea,
title = "Surgical implications of Helicobacter pylori infection.",
abstract = "Helicobacter pylori infection is the most common cause of peptic ulcer disease and is an etiologic factor in the development of gastric malignancies. Eradication of H. pylori heals most uncomplicated peptic ulcers, as well as preventing their relapse. In addition, H. pylori therapy has recently been used as a first line treatment for most low grade MALT lymphomas. Despite its efficacy, a small percentage of patients with peptic ulcer disease will require operative intervention and the indications for surgical intervention for the patient with peptic ulcer disease include; intractability, gastric outlet obstruction, acute perforation, and bleeding uncontrolled by endoscopic intervention. H. pylori has also been shown to be associated with an increased risk of gastric adenocarcinoma and surgical exploration may play a role in diagnosis, staging and treatment. Finally, the relationship between H. pylori infection and the development of gastric MALT lymphoma is well established. While treatment for H. pylori infection is indicated for low grade MALT lymphomas, surgical resection may be indicated for treatment failures, as well as for certain high grade lesions.",
author = "Clarke, {K. O.} and Lawrence Harrison",
year = "2001",
month = "1",
day = "1",
language = "English (US)",
volume = "6",
journal = "Frontiers in Bioscience - Landmark",
issn = "1093-9946",
publisher = "Frontiers in Bioscience",

}

Surgical implications of Helicobacter pylori infection. / Clarke, K. O.; Harrison, Lawrence.

In: Frontiers in bioscience : a journal and virtual library, Vol. 6, 01.01.2001.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Surgical implications of Helicobacter pylori infection.

AU - Clarke, K. O.

AU - Harrison, Lawrence

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Helicobacter pylori infection is the most common cause of peptic ulcer disease and is an etiologic factor in the development of gastric malignancies. Eradication of H. pylori heals most uncomplicated peptic ulcers, as well as preventing their relapse. In addition, H. pylori therapy has recently been used as a first line treatment for most low grade MALT lymphomas. Despite its efficacy, a small percentage of patients with peptic ulcer disease will require operative intervention and the indications for surgical intervention for the patient with peptic ulcer disease include; intractability, gastric outlet obstruction, acute perforation, and bleeding uncontrolled by endoscopic intervention. H. pylori has also been shown to be associated with an increased risk of gastric adenocarcinoma and surgical exploration may play a role in diagnosis, staging and treatment. Finally, the relationship between H. pylori infection and the development of gastric MALT lymphoma is well established. While treatment for H. pylori infection is indicated for low grade MALT lymphomas, surgical resection may be indicated for treatment failures, as well as for certain high grade lesions.

AB - Helicobacter pylori infection is the most common cause of peptic ulcer disease and is an etiologic factor in the development of gastric malignancies. Eradication of H. pylori heals most uncomplicated peptic ulcers, as well as preventing their relapse. In addition, H. pylori therapy has recently been used as a first line treatment for most low grade MALT lymphomas. Despite its efficacy, a small percentage of patients with peptic ulcer disease will require operative intervention and the indications for surgical intervention for the patient with peptic ulcer disease include; intractability, gastric outlet obstruction, acute perforation, and bleeding uncontrolled by endoscopic intervention. H. pylori has also been shown to be associated with an increased risk of gastric adenocarcinoma and surgical exploration may play a role in diagnosis, staging and treatment. Finally, the relationship between H. pylori infection and the development of gastric MALT lymphoma is well established. While treatment for H. pylori infection is indicated for low grade MALT lymphomas, surgical resection may be indicated for treatment failures, as well as for certain high grade lesions.

UR - http://www.scopus.com/inward/record.url?scp=0035490863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035490863&partnerID=8YFLogxK

M3 - Review article

VL - 6

JO - Frontiers in Bioscience - Landmark

JF - Frontiers in Bioscience - Landmark

SN - 1093-9946

ER -