Seronegative Lyme Disease

David A. Relman, Gideon Nesher, Thomas G. Osborn, Terry L. Moore, Felix Mor, Leonard Leibovici, Raymond J. Dattwyler, David J. Volkman, Benjamin J. Luft, John Halperin, Josephine Thomas, Marc G. Golightly

Research output: Contribution to journalLetter

3 Citations (Scopus)

Abstract

To the Editor: Dattwyler and his associates (Dec. 1 issue)1 make important and provocative observations about a group of patients with a clinical diagnosis of chronic Lyme disease who have no apparent serologic response to the causative agent, Borrelia burgdorferi. The specific T-cell proliferative response in these patients was similar to that found in a group of seropositive patients with chronic Lyme disease, suggesting that in some persons with this clinical syndrome, the T-cell and B-cell responses to B. burgdorferi are vastly unequal. One point needs clarification: although the serologic status of the patients seems to have been known…

Original languageEnglish (US)
Pages (from-to)1279-1280
Number of pages2
JournalNew England Journal of Medicine
Volume320
Issue number19
DOIs
StatePublished - May 11 1989
Externally publishedYes

Fingerprint

Lyme Disease
Borrelia burgdorferi
Chronic Disease
T-Lymphocytes
B-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Relman, D. A., Nesher, G., Osborn, T. G., Moore, T. L., Mor, F., Leibovici, L., ... Golightly, M. G. (1989). Seronegative Lyme Disease. New England Journal of Medicine, 320(19), 1279-1280. https://doi.org/10.1056/NEJM198905113201913
Relman, David A. ; Nesher, Gideon ; Osborn, Thomas G. ; Moore, Terry L. ; Mor, Felix ; Leibovici, Leonard ; Dattwyler, Raymond J. ; Volkman, David J. ; Luft, Benjamin J. ; Halperin, John ; Thomas, Josephine ; Golightly, Marc G. / Seronegative Lyme Disease. In: New England Journal of Medicine. 1989 ; Vol. 320, No. 19. pp. 1279-1280.
@article{3ffe0d8001d749c6b91ceab99be3c260,
title = "Seronegative Lyme Disease",
abstract = "To the Editor: Dattwyler and his associates (Dec. 1 issue)1 make important and provocative observations about a group of patients with a clinical diagnosis of chronic Lyme disease who have no apparent serologic response to the causative agent, Borrelia burgdorferi. The specific T-cell proliferative response in these patients was similar to that found in a group of seropositive patients with chronic Lyme disease, suggesting that in some persons with this clinical syndrome, the T-cell and B-cell responses to B. burgdorferi are vastly unequal. One point needs clarification: although the serologic status of the patients seems to have been known…",
author = "Relman, {David A.} and Gideon Nesher and Osborn, {Thomas G.} and Moore, {Terry L.} and Felix Mor and Leonard Leibovici and Dattwyler, {Raymond J.} and Volkman, {David J.} and Luft, {Benjamin J.} and John Halperin and Josephine Thomas and Golightly, {Marc G.}",
year = "1989",
month = "5",
day = "11",
doi = "10.1056/NEJM198905113201913",
language = "English (US)",
volume = "320",
pages = "1279--1280",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "19",

}

Relman, DA, Nesher, G, Osborn, TG, Moore, TL, Mor, F, Leibovici, L, Dattwyler, RJ, Volkman, DJ, Luft, BJ, Halperin, J, Thomas, J & Golightly, MG 1989, 'Seronegative Lyme Disease', New England Journal of Medicine, vol. 320, no. 19, pp. 1279-1280. https://doi.org/10.1056/NEJM198905113201913

Seronegative Lyme Disease. / Relman, David A.; Nesher, Gideon; Osborn, Thomas G.; Moore, Terry L.; Mor, Felix; Leibovici, Leonard; Dattwyler, Raymond J.; Volkman, David J.; Luft, Benjamin J.; Halperin, John; Thomas, Josephine; Golightly, Marc G.

In: New England Journal of Medicine, Vol. 320, No. 19, 11.05.1989, p. 1279-1280.

Research output: Contribution to journalLetter

TY - JOUR

T1 - Seronegative Lyme Disease

AU - Relman, David A.

AU - Nesher, Gideon

AU - Osborn, Thomas G.

AU - Moore, Terry L.

AU - Mor, Felix

AU - Leibovici, Leonard

AU - Dattwyler, Raymond J.

AU - Volkman, David J.

AU - Luft, Benjamin J.

AU - Halperin, John

AU - Thomas, Josephine

AU - Golightly, Marc G.

PY - 1989/5/11

Y1 - 1989/5/11

N2 - To the Editor: Dattwyler and his associates (Dec. 1 issue)1 make important and provocative observations about a group of patients with a clinical diagnosis of chronic Lyme disease who have no apparent serologic response to the causative agent, Borrelia burgdorferi. The specific T-cell proliferative response in these patients was similar to that found in a group of seropositive patients with chronic Lyme disease, suggesting that in some persons with this clinical syndrome, the T-cell and B-cell responses to B. burgdorferi are vastly unequal. One point needs clarification: although the serologic status of the patients seems to have been known…

AB - To the Editor: Dattwyler and his associates (Dec. 1 issue)1 make important and provocative observations about a group of patients with a clinical diagnosis of chronic Lyme disease who have no apparent serologic response to the causative agent, Borrelia burgdorferi. The specific T-cell proliferative response in these patients was similar to that found in a group of seropositive patients with chronic Lyme disease, suggesting that in some persons with this clinical syndrome, the T-cell and B-cell responses to B. burgdorferi are vastly unequal. One point needs clarification: although the serologic status of the patients seems to have been known…

UR - http://www.scopus.com/inward/record.url?scp=0024506226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024506226&partnerID=8YFLogxK

U2 - 10.1056/NEJM198905113201913

DO - 10.1056/NEJM198905113201913

M3 - Letter

VL - 320

SP - 1279

EP - 1280

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 19

ER -

Relman DA, Nesher G, Osborn TG, Moore TL, Mor F, Leibovici L et al. Seronegative Lyme Disease. New England Journal of Medicine. 1989 May 11;320(19):1279-1280. https://doi.org/10.1056/NEJM198905113201913