Segmental comparison between a dedicated bifurcation stent and balloon angioplasty using intravascular ultrasound and three-dimensional quantitative coronary angiography: A subgroup analysis of the Tryton IDE randomized trial

Maik J. Grundeken, Hector M. Garcia-Garcia, Indulis Kumsars, Maciej Lesiak, Peter Kayaert, Jo Dens, Pieter R. Stella, Robbert J. de Winter, Linda L. Laak, Philippe Généreux, Aaron V. Kaplan, Martin B. Leon, Joanna J. Wykrzykowska, Yoshinobu Onuma, Patrick W. Serruys

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: Randomized comparison between the Tryton Side Branch Stent (Tryton Medical, Durham, NC), used in combination with a main branch drug-eluting stent (DES), and side branch balloon angioplasty (SBBA, in combination with a main branch DES) using intravascular ultrasound (IVUS), and three-dimensional quantitative coronary angiography (3D-QCA). Background: The Tryton stent has been developed to improve clinical outcomes after percutaneous coronary intervention (PCI) of bifurcation lesions. Methods: We present the pre-specified IVUS (n = 159) and 3D-QCA (n = 190) sub-group analyses of the Tryton coronary bifurcation trial (randomizing Tryton vs. SBBA). Results: There were no differences in the main branch with regard to minimal lumen area (MLA) (5.33 ± 1.37 in Tryton vs. 5.69 ± 1.72 mm2 in SBBA, P = 0.235) with low neo-intima area in both groups. In the side branch, there were also no statistical significant differences between both groups (3.04 ± 1.02 in Tryton vs. 3.46 ± 1.15 mm2 in SBBA, P = 0.072). On 3D-QCA, no differences in minimal lumen diameter (MLD) and percentage diameter stenosis (%DS) were observed in the proximal and distal main branches. In the side branch, there were also no differences found in %DS and MLD (MLD: 1.34 ± 0.043 mm [Tryton] vs. 1.45 ± 0.31 mm [SBBA], P = 0.090). Conclusions: There were no differences in 9-month luminal dimensions of the side branch between the Tryton Stent and Side Branch Balloon Angioplasty, as assessed with IVUS (MLA) and 3D QCA (MLD). Angiographic and ultrasound results of the main branch were not negatively influenced by the Tryton stent.

Original languageEnglish (US)
Pages (from-to)E53-E63
JournalCatheterization and Cardiovascular Interventions
Volume89
Issue number2
DOIs
StatePublished - Feb 1 2017

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Balloon Angioplasty
Coronary Angiography
Stents
Drug-Eluting Stents
Percutaneous Coronary Intervention
Pathologic Constriction

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Grundeken, Maik J. ; Garcia-Garcia, Hector M. ; Kumsars, Indulis ; Lesiak, Maciej ; Kayaert, Peter ; Dens, Jo ; Stella, Pieter R. ; de Winter, Robbert J. ; Laak, Linda L. ; Généreux, Philippe ; Kaplan, Aaron V. ; Leon, Martin B. ; Wykrzykowska, Joanna J. ; Onuma, Yoshinobu ; Serruys, Patrick W. / Segmental comparison between a dedicated bifurcation stent and balloon angioplasty using intravascular ultrasound and three-dimensional quantitative coronary angiography : A subgroup analysis of the Tryton IDE randomized trial. In: Catheterization and Cardiovascular Interventions. 2017 ; Vol. 89, No. 2. pp. E53-E63.
@article{233190832c1b4d3cba6201b3532b9269,
title = "Segmental comparison between a dedicated bifurcation stent and balloon angioplasty using intravascular ultrasound and three-dimensional quantitative coronary angiography: A subgroup analysis of the Tryton IDE randomized trial",
abstract = "Objective: Randomized comparison between the Tryton Side Branch Stent (Tryton Medical, Durham, NC), used in combination with a main branch drug-eluting stent (DES), and side branch balloon angioplasty (SBBA, in combination with a main branch DES) using intravascular ultrasound (IVUS), and three-dimensional quantitative coronary angiography (3D-QCA). Background: The Tryton stent has been developed to improve clinical outcomes after percutaneous coronary intervention (PCI) of bifurcation lesions. Methods: We present the pre-specified IVUS (n = 159) and 3D-QCA (n = 190) sub-group analyses of the Tryton coronary bifurcation trial (randomizing Tryton vs. SBBA). Results: There were no differences in the main branch with regard to minimal lumen area (MLA) (5.33 ± 1.37 in Tryton vs. 5.69 ± 1.72 mm2 in SBBA, P = 0.235) with low neo-intima area in both groups. In the side branch, there were also no statistical significant differences between both groups (3.04 ± 1.02 in Tryton vs. 3.46 ± 1.15 mm2 in SBBA, P = 0.072). On 3D-QCA, no differences in minimal lumen diameter (MLD) and percentage diameter stenosis ({\%}DS) were observed in the proximal and distal main branches. In the side branch, there were also no differences found in {\%}DS and MLD (MLD: 1.34 ± 0.043 mm [Tryton] vs. 1.45 ± 0.31 mm [SBBA], P = 0.090). Conclusions: There were no differences in 9-month luminal dimensions of the side branch between the Tryton Stent and Side Branch Balloon Angioplasty, as assessed with IVUS (MLA) and 3D QCA (MLD). Angiographic and ultrasound results of the main branch were not negatively influenced by the Tryton stent.",
author = "Grundeken, {Maik J.} and Garcia-Garcia, {Hector M.} and Indulis Kumsars and Maciej Lesiak and Peter Kayaert and Jo Dens and Stella, {Pieter R.} and {de Winter}, {Robbert J.} and Laak, {Linda L.} and Philippe G{\'e}n{\'e}reux and Kaplan, {Aaron V.} and Leon, {Martin B.} and Wykrzykowska, {Joanna J.} and Yoshinobu Onuma and Serruys, {Patrick W.}",
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pages = "E53--E63",
journal = "Catheterization and Cardiovascular Interventions",
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Grundeken, MJ, Garcia-Garcia, HM, Kumsars, I, Lesiak, M, Kayaert, P, Dens, J, Stella, PR, de Winter, RJ, Laak, LL, Généreux, P, Kaplan, AV, Leon, MB, Wykrzykowska, JJ, Onuma, Y & Serruys, PW 2017, 'Segmental comparison between a dedicated bifurcation stent and balloon angioplasty using intravascular ultrasound and three-dimensional quantitative coronary angiography: A subgroup analysis of the Tryton IDE randomized trial', Catheterization and Cardiovascular Interventions, vol. 89, no. 2, pp. E53-E63. https://doi.org/10.1002/ccd.26527

Segmental comparison between a dedicated bifurcation stent and balloon angioplasty using intravascular ultrasound and three-dimensional quantitative coronary angiography : A subgroup analysis of the Tryton IDE randomized trial. / Grundeken, Maik J.; Garcia-Garcia, Hector M.; Kumsars, Indulis; Lesiak, Maciej; Kayaert, Peter; Dens, Jo; Stella, Pieter R.; de Winter, Robbert J.; Laak, Linda L.; Généreux, Philippe; Kaplan, Aaron V.; Leon, Martin B.; Wykrzykowska, Joanna J.; Onuma, Yoshinobu; Serruys, Patrick W.

In: Catheterization and Cardiovascular Interventions, Vol. 89, No. 2, 01.02.2017, p. E53-E63.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Segmental comparison between a dedicated bifurcation stent and balloon angioplasty using intravascular ultrasound and three-dimensional quantitative coronary angiography

T2 - A subgroup analysis of the Tryton IDE randomized trial

AU - Grundeken, Maik J.

AU - Garcia-Garcia, Hector M.

AU - Kumsars, Indulis

AU - Lesiak, Maciej

AU - Kayaert, Peter

AU - Dens, Jo

AU - Stella, Pieter R.

AU - de Winter, Robbert J.

AU - Laak, Linda L.

AU - Généreux, Philippe

AU - Kaplan, Aaron V.

AU - Leon, Martin B.

AU - Wykrzykowska, Joanna J.

AU - Onuma, Yoshinobu

AU - Serruys, Patrick W.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Objective: Randomized comparison between the Tryton Side Branch Stent (Tryton Medical, Durham, NC), used in combination with a main branch drug-eluting stent (DES), and side branch balloon angioplasty (SBBA, in combination with a main branch DES) using intravascular ultrasound (IVUS), and three-dimensional quantitative coronary angiography (3D-QCA). Background: The Tryton stent has been developed to improve clinical outcomes after percutaneous coronary intervention (PCI) of bifurcation lesions. Methods: We present the pre-specified IVUS (n = 159) and 3D-QCA (n = 190) sub-group analyses of the Tryton coronary bifurcation trial (randomizing Tryton vs. SBBA). Results: There were no differences in the main branch with regard to minimal lumen area (MLA) (5.33 ± 1.37 in Tryton vs. 5.69 ± 1.72 mm2 in SBBA, P = 0.235) with low neo-intima area in both groups. In the side branch, there were also no statistical significant differences between both groups (3.04 ± 1.02 in Tryton vs. 3.46 ± 1.15 mm2 in SBBA, P = 0.072). On 3D-QCA, no differences in minimal lumen diameter (MLD) and percentage diameter stenosis (%DS) were observed in the proximal and distal main branches. In the side branch, there were also no differences found in %DS and MLD (MLD: 1.34 ± 0.043 mm [Tryton] vs. 1.45 ± 0.31 mm [SBBA], P = 0.090). Conclusions: There were no differences in 9-month luminal dimensions of the side branch between the Tryton Stent and Side Branch Balloon Angioplasty, as assessed with IVUS (MLA) and 3D QCA (MLD). Angiographic and ultrasound results of the main branch were not negatively influenced by the Tryton stent.

AB - Objective: Randomized comparison between the Tryton Side Branch Stent (Tryton Medical, Durham, NC), used in combination with a main branch drug-eluting stent (DES), and side branch balloon angioplasty (SBBA, in combination with a main branch DES) using intravascular ultrasound (IVUS), and three-dimensional quantitative coronary angiography (3D-QCA). Background: The Tryton stent has been developed to improve clinical outcomes after percutaneous coronary intervention (PCI) of bifurcation lesions. Methods: We present the pre-specified IVUS (n = 159) and 3D-QCA (n = 190) sub-group analyses of the Tryton coronary bifurcation trial (randomizing Tryton vs. SBBA). Results: There were no differences in the main branch with regard to minimal lumen area (MLA) (5.33 ± 1.37 in Tryton vs. 5.69 ± 1.72 mm2 in SBBA, P = 0.235) with low neo-intima area in both groups. In the side branch, there were also no statistical significant differences between both groups (3.04 ± 1.02 in Tryton vs. 3.46 ± 1.15 mm2 in SBBA, P = 0.072). On 3D-QCA, no differences in minimal lumen diameter (MLD) and percentage diameter stenosis (%DS) were observed in the proximal and distal main branches. In the side branch, there were also no differences found in %DS and MLD (MLD: 1.34 ± 0.043 mm [Tryton] vs. 1.45 ± 0.31 mm [SBBA], P = 0.090). Conclusions: There were no differences in 9-month luminal dimensions of the side branch between the Tryton Stent and Side Branch Balloon Angioplasty, as assessed with IVUS (MLA) and 3D QCA (MLD). Angiographic and ultrasound results of the main branch were not negatively influenced by the Tryton stent.

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U2 - 10.1002/ccd.26527

DO - 10.1002/ccd.26527

M3 - Article

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