Resolution of factor X deficiency in primary amyloidosis following splenectomy

Elliot Rosenstein, S. H. Itzkowitz, A. S. Penziner, J. I. Cohen, R. A. Mornaghi

Research output: Contribution to journalArticle

Abstract

A 57-year-old man with primary amyloidosis was initially seen with hematuria, cutaneous bleeding, and hepatosplenomegaly. Factor X was determined to be 10% to 16% of normal plasma values. Administration of vitamin K-dependent factor concentrate transiently improved in vitro clotting tests but did not alter the clinical course. Following a splenectomy, bleeding ceased and factor X levels returned to normal, remaining so despite discontinuation of factor concentrate infusion. Amyloid fibrils extracted from the patient's spleen were determined to be derived from λ V1 light chains. The importance of splenectomy as an effective therapeutic modality is discussed.

Original languageEnglish (US)
Pages (from-to)597-599
Number of pages3
JournalArchives of Internal Medicine
Volume143
Issue number3
DOIs
StatePublished - May 5 1983

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Factor X Deficiency
Factor X
Splenectomy
Hemorrhage
Vitamin K
Hematuria
Amyloid
Reference Values
Spleen
Light
Skin
Primary amyloidosis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Rosenstein, Elliot ; Itzkowitz, S. H. ; Penziner, A. S. ; Cohen, J. I. ; Mornaghi, R. A. / Resolution of factor X deficiency in primary amyloidosis following splenectomy. In: Archives of Internal Medicine. 1983 ; Vol. 143, No. 3. pp. 597-599.
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Resolution of factor X deficiency in primary amyloidosis following splenectomy. / Rosenstein, Elliot; Itzkowitz, S. H.; Penziner, A. S.; Cohen, J. I.; Mornaghi, R. A.

In: Archives of Internal Medicine, Vol. 143, No. 3, 05.05.1983, p. 597-599.

Research output: Contribution to journalArticle

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