Resolution of Factor X Deficiency in Primary Amyloidosis Following Splenectomy

Elliot Rosenstein, Steven H. Itzkowitz, Alan S. Penziner, Jonathan I. Cohen, Ricardo A. Mornaghi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A 57-year-old man with primary amyloidosis was initially seen with hematuria, cutaneous bleeding, and hepatosplenomegaly. Factor X was determined to be 10% to 16% of normal plasma values. Administration of vitamin K-dependent factor concentrate transiently improved in vitro clotting tests but did not alter the clinical course. Following a splenectomy, bleeding ceased and factor X levels returned to normal, remaining so despite discontinuation of factor concentrate infusion. Amyloid fibrils extracted from the patient's spleen were determined to be derived from λV1 light chains. The importance of splenectomy as an effective therapeutic modality is discussed.

Original languageEnglish (US)
Pages (from-to)597-599
Number of pages3
JournalArchives of Internal Medicine
Volume143
Issue number3
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

Fingerprint

Factor X Deficiency
Factor X
Splenectomy
Hemorrhage
Vitamin K
Hematuria
Amyloid
Reference Values
Spleen
Light
Skin
Primary amyloidosis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Rosenstein, Elliot ; Itzkowitz, Steven H. ; Penziner, Alan S. ; Cohen, Jonathan I. ; Mornaghi, Ricardo A. / Resolution of Factor X Deficiency in Primary Amyloidosis Following Splenectomy. In: Archives of Internal Medicine. 1983 ; Vol. 143, No. 3. pp. 597-599.
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Resolution of Factor X Deficiency in Primary Amyloidosis Following Splenectomy. / Rosenstein, Elliot; Itzkowitz, Steven H.; Penziner, Alan S.; Cohen, Jonathan I.; Mornaghi, Ricardo A.

In: Archives of Internal Medicine, Vol. 143, No. 3, 01.01.1983, p. 597-599.

Research output: Contribution to journalArticle

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