Renal and Electrolyte Effects of Total Parenteral Nutrition

Vecihi Batuman, Albert Dreisbach, John K. Maesaka, Michael Rothkopf, Elizabeth Ross

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Effects of short-term (4-14 days) total parenteral nutrition on renal handling of water and electrolytes were studied retrospectively in 24 patients and prospectively in eight patients. There was 33% incidence of hyponatremia and significant reductions in serum creatinine (from 1.03 ± 0.06 to 0.88 ± 0.06 mg/dl, p < 0.001), phosphorus (from 3.2 ± 0.14 to 2.5 ± 0.17 mg/dl, p < 0.005) and uric acid (from 6.09 ± 0.38 to 3.66 ± 0.24 mg/dl, p < 0.001) were observed. Hypouricemia correlated with increased fractional excretion of urate (r = —0.81,p < 0.05). Hypophosphatemia was associated with increased tubular reabsorption of phosphate. Clearance studies in eight patients showed high urine flow rate (1.7 ± 0.2 ml/min), osmolar clearance (3.2 ± 0.7 ml/min), urinary nonelectrolyte, nonurea solute excretion (0.23 ± 0.14 mmol/min), and negative free water clearance (TcH2O = 1.5 ± 0.6 ml/min). These data suggest presence of compartmental shifts, expanded extracellular fluid volume, and possible direct effects on renal tubular transport functions during total parenteral nutrition. (Journal of Parenteral and Enteral Nutrition 8:546-551, 1984).

Original languageEnglish (US)
Pages (from-to)546-551
Number of pages6
JournalJournal of Parenteral and Enteral Nutrition
Volume8
Issue number5
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

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Total Parenteral Nutrition
Electrolytes
Uric Acid
Kidney
Hypophosphatemia
Hyponatremia
Water
Extracellular Fluid
Parenteral Nutrition
Enteral Nutrition
Phosphorus
Creatinine
Phosphates
Urine
Incidence
Serum

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Batuman, Vecihi ; Dreisbach, Albert ; Maesaka, John K. ; Rothkopf, Michael ; Ross, Elizabeth. / Renal and Electrolyte Effects of Total Parenteral Nutrition. In: Journal of Parenteral and Enteral Nutrition. 1984 ; Vol. 8, No. 5. pp. 546-551.
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Renal and Electrolyte Effects of Total Parenteral Nutrition. / Batuman, Vecihi; Dreisbach, Albert; Maesaka, John K.; Rothkopf, Michael; Ross, Elizabeth.

In: Journal of Parenteral and Enteral Nutrition, Vol. 8, No. 5, 01.01.1984, p. 546-551.

Research output: Contribution to journalArticle

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T1 - Renal and Electrolyte Effects of Total Parenteral Nutrition

AU - Batuman, Vecihi

AU - Dreisbach, Albert

AU - Maesaka, John K.

AU - Rothkopf, Michael

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