Recurrence of wegener's granulomatosis following renal transplantation

Elliot Rosenstein, S. Ribot, E. Ventresca, Neil Kramer

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A 43-yr-old man with a 19-yr history of Wegener's granulomatosis presented with recurrent haematuria, pulmonary infiltrate, cutaneous vasculitis, nasal mucosal involvement and elevation of ANCA levels, 2 yr following successful cadaveric renal transplantation, despite continued immunosuppressive therapy with cyclosporine, azathioprine and prednisone. Re-introduction of cyclophosphamide therapy resulted in prompt resolution of clinical and laboratory abnormalities. The superiority of cyclophosphamide over cyclosporine for maintaining suppression of Wegener's granulomatosis is substantiated in a critical review of the literature.

Original languageEnglish (US)
Pages (from-to)869-871
Number of pages3
JournalRheumatology
Volume33
Issue number9
DOIs
StatePublished - Sep 1 1994

Fingerprint

Granulomatosis with Polyangiitis
Kidney Transplantation
Cyclophosphamide
Cyclosporine
Recurrence
Antineutrophil Cytoplasmic Antibodies
Azathioprine
Hematuria
Immunosuppressive Agents
Vasculitis
Prednisone
Nose
Lung
Skin
Therapeutics

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Pharmacology (medical)

Cite this

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Recurrence of wegener's granulomatosis following renal transplantation. / Rosenstein, Elliot; Ribot, S.; Ventresca, E.; Kramer, Neil.

In: Rheumatology, Vol. 33, No. 9, 01.09.1994, p. 869-871.

Research output: Contribution to journalArticle

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