Recurrence of wegener's granulomatosis following renal transplantation

E. D. Rosenstein, S. Ribot, E. Ventresca, N. Kramer

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A 43-yr-old man with a 19-yr history of Wegener's granulomatosis presented with recurrent haematuria, pulmonary infiltrate, cutaneous vasculitis, nasal mucosal involvement and elevation of ANCA levels, 2 yr following successful cadaveric renal transplantation, despite continued immunosuppressive therapy with cyclosporine, azathioprine and prednisone. Re-introduction of cyclophosphamide therapy resulted in prompt resolution of clinical and laboratory abnormalities. The superiority of cyclophosphamide over cyclosporine for maintaining suppression of Wegener's granulomatosis is substantiated in a critical review of the literature.

Original languageEnglish (US)
Pages (from-to)869-871
Number of pages3
JournalRheumatology
Volume33
Issue number9
DOIs
StatePublished - Sep 1 1994
Externally publishedYes

Fingerprint

Granulomatosis with Polyangiitis
Kidney Transplantation
Cyclophosphamide
Cyclosporine
Recurrence
Antineutrophil Cytoplasmic Antibodies
Azathioprine
Hematuria
Immunosuppressive Agents
Vasculitis
Prednisone
Nose
Lung
Skin
Therapeutics

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Pharmacology (medical)

Cite this

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Recurrence of wegener's granulomatosis following renal transplantation. / Rosenstein, E. D.; Ribot, S.; Ventresca, E.; Kramer, N.

In: Rheumatology, Vol. 33, No. 9, 01.09.1994, p. 869-871.

Research output: Contribution to journalArticle

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