Recent trends in the management of minor salivary gland carcinoma

Vincent Vander Poorten, Jennifer Hunt, Patrick J. Bradley, Missak Haigentz, Alessandra Rinaldo, William M. Mendenhall, Carlos Suarez, Carl Silver, Robert P. Takes, Alfio Ferlito

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

The current management of minor salivary gland cancer is reviewed. These malignancies often present as a submucosal swelling and have been reported at all anatomic subsites of the head and neck. Modern imaging is essential in evaluating the location and the anatomic extent of disease. An incisional or punch biopsy determines the histologic type and grade. Recent advances in molecular biology have yielded diagnostic and potential therapeutic targets that may change our treatment in the future. Complete resection is the treatment of choice. Unfortunately, given the proximity of essential structures, the need to balance functional and cosmetic with oncologic consequences can interfere with an adequate "clear margin." The neck should be treated when there is evidence of regional metastasis or when subclinical metastatic risk exceeds 15%. Surgery alone cures most low-stage, low-grade tumors, all other stages and grades require postoperative radiotherapy. Systemic treatment for locoregional and distant failure remains disappointing.

Original languageEnglish (US)
Pages (from-to)444-455
Number of pages12
JournalHead and Neck
Volume36
Issue number3
DOIs
StatePublished - Mar 1 2014
Externally publishedYes

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Minor Salivary Glands
Carcinoma
Neck
Salivary Gland Neoplasms
Therapeutics
Cosmetics
Molecular Biology
Neoplasms
Radiotherapy
Head
Neoplasm Metastasis
Biopsy

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Poorten, V. V., Hunt, J., Bradley, P. J., Haigentz, M., Rinaldo, A., Mendenhall, W. M., ... Ferlito, A. (2014). Recent trends in the management of minor salivary gland carcinoma. Head and Neck, 36(3), 444-455. https://doi.org/10.1002/hed.23249
Poorten, Vincent Vander ; Hunt, Jennifer ; Bradley, Patrick J. ; Haigentz, Missak ; Rinaldo, Alessandra ; Mendenhall, William M. ; Suarez, Carlos ; Silver, Carl ; Takes, Robert P. ; Ferlito, Alfio. / Recent trends in the management of minor salivary gland carcinoma. In: Head and Neck. 2014 ; Vol. 36, No. 3. pp. 444-455.
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Poorten, VV, Hunt, J, Bradley, PJ, Haigentz, M, Rinaldo, A, Mendenhall, WM, Suarez, C, Silver, C, Takes, RP & Ferlito, A 2014, 'Recent trends in the management of minor salivary gland carcinoma', Head and Neck, vol. 36, no. 3, pp. 444-455. https://doi.org/10.1002/hed.23249

Recent trends in the management of minor salivary gland carcinoma. / Poorten, Vincent Vander; Hunt, Jennifer; Bradley, Patrick J.; Haigentz, Missak; Rinaldo, Alessandra; Mendenhall, William M.; Suarez, Carlos; Silver, Carl; Takes, Robert P.; Ferlito, Alfio.

In: Head and Neck, Vol. 36, No. 3, 01.03.2014, p. 444-455.

Research output: Contribution to journalReview article

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AU - Bradley, Patrick J.

AU - Haigentz, Missak

AU - Rinaldo, Alessandra

AU - Mendenhall, William M.

AU - Suarez, Carlos

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AU - Takes, Robert P.

AU - Ferlito, Alfio

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Poorten VV, Hunt J, Bradley PJ, Haigentz M, Rinaldo A, Mendenhall WM et al. Recent trends in the management of minor salivary gland carcinoma. Head and Neck. 2014 Mar 1;36(3):444-455. https://doi.org/10.1002/hed.23249