Quantitation of myocardial dysfunction in ischemic heart disease by echocardiographic endocardial surface mapping

Correlation with hemodynamic status

John P. Fisher, Michael H. Picard, Joseph S. Mikan, Daniel B. Fram, Jane R. Fisher, Jeffrey Kluger, David D. Waters, Linda Gillam

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Autopsy studies have suggested that infarction of >35% of the myocardium is associated with cardiogenic shock. However, the relation between the extent of myocardial dysfunction and hemodynamic status has not been defined in patients in vivo. This study investigated, in patients with short-term and chronic left ventricular dysfunction, the relation between hemodynamic status and the extent of regional dyssynergia measured by two-dimensional echocardiography with quantitative endocardial surface mapping. Sixty patients were classified into hemodynamic groups by pulmonary capillary wedge pressure and cardiac index. Two-dimensional echocardiograms were used to calculate left ventricular endocardial surface area index (ESAi), abnormal wall motion index (AWMi), percentage myocardial dysfunction (%MD), and number of wall motion abnormalities. All patients in class 4 (high pulmonary capillary wedge pressure and low cardiac index had ≥60% MD. With univariate analysis, hemodynamic class correlated with ESAi, AWMi, %MD, the number of wall motion abnormalities, and two clinical variables (number of infarctions and use of diuretic agents). By stepwise linear regression, only AWMi and the number of infarctions were independently predictive of hemodynamic status.

Original languageEnglish (US)
Pages (from-to)1114-1121
Number of pages8
JournalAmerican Heart Journal
Volume129
Issue number6
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

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Myocardial Ischemia
Hemodynamics
Infarction
Pulmonary Wedge Pressure
Cardiogenic Shock
Left Ventricular Dysfunction
Ataxia
Diuretics
Echocardiography
Autopsy
Linear Models
Myocardium

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Fisher, John P. ; Picard, Michael H. ; Mikan, Joseph S. ; Fram, Daniel B. ; Fisher, Jane R. ; Kluger, Jeffrey ; Waters, David D. ; Gillam, Linda. / Quantitation of myocardial dysfunction in ischemic heart disease by echocardiographic endocardial surface mapping : Correlation with hemodynamic status. In: American Heart Journal. 1995 ; Vol. 129, No. 6. pp. 1114-1121.
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Quantitation of myocardial dysfunction in ischemic heart disease by echocardiographic endocardial surface mapping : Correlation with hemodynamic status. / Fisher, John P.; Picard, Michael H.; Mikan, Joseph S.; Fram, Daniel B.; Fisher, Jane R.; Kluger, Jeffrey; Waters, David D.; Gillam, Linda.

In: American Heart Journal, Vol. 129, No. 6, 01.01.1995, p. 1114-1121.

Research output: Contribution to journalArticle

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