Primary leptomeningeal lymphoma: Report of 9 cases, diagnosis with immunocytochemical analysis, and review of the literature

D. H. Lachance, B. P. O’Neill, D. R. Macdonald, K. A. Jaeckle, T. E. Witzig, C. Y. Li, J. B. Posner

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

We describe 9 patients who presented with a neoplastic meningitis of lymphomatous origin. No evidence of parenchymal central nervous system or systemic tumor was identified either at the time of presentation or throughout the course of their disease. We have chosen to call this entity “primary leptomeningeal lymphoma” (PLML). This unusual form of neurologic lymphoma must be differentiated from the more common clinical situations of primary parenchymal lymphoma with meningeal involvement and systemic lymphoma complicated by lymphomatous meningitis.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalNeurology
Volume41
Issue number1
StatePublished - Jan 1 1991
Externally publishedYes

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Lymphoma
Meningitis
Nervous System
Central Nervous System
Neoplasms

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Lachance, D. H., O’Neill, B. P., Macdonald, D. R., Jaeckle, K. A., Witzig, T. E., Li, C. Y., & Posner, J. B. (1991). Primary leptomeningeal lymphoma: Report of 9 cases, diagnosis with immunocytochemical analysis, and review of the literature. Neurology, 41(1), 95-100.
Lachance, D. H. ; O’Neill, B. P. ; Macdonald, D. R. ; Jaeckle, K. A. ; Witzig, T. E. ; Li, C. Y. ; Posner, J. B. / Primary leptomeningeal lymphoma : Report of 9 cases, diagnosis with immunocytochemical analysis, and review of the literature. In: Neurology. 1991 ; Vol. 41, No. 1. pp. 95-100.
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Lachance, DH, O’Neill, BP, Macdonald, DR, Jaeckle, KA, Witzig, TE, Li, CY & Posner, JB 1991, 'Primary leptomeningeal lymphoma: Report of 9 cases, diagnosis with immunocytochemical analysis, and review of the literature', Neurology, vol. 41, no. 1, pp. 95-100.

Primary leptomeningeal lymphoma : Report of 9 cases, diagnosis with immunocytochemical analysis, and review of the literature. / Lachance, D. H.; O’Neill, B. P.; Macdonald, D. R.; Jaeckle, K. A.; Witzig, T. E.; Li, C. Y.; Posner, J. B.

In: Neurology, Vol. 41, No. 1, 01.01.1991, p. 95-100.

Research output: Contribution to journalArticle

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Lachance DH, O’Neill BP, Macdonald DR, Jaeckle KA, Witzig TE, Li CY et al. Primary leptomeningeal lymphoma: Report of 9 cases, diagnosis with immunocytochemical analysis, and review of the literature. Neurology. 1991 Jan 1;41(1):95-100.