Postoperative strategies after primary surgery for squamous cell carcinoma of the head and neck

Johannes A. Langendijk, Alfio Ferlito, Robert P. Takes, Juan P. Rodrigo, Carl Suárez, Primo Strojan, Missak Haigentz, Alessandra Rinaldo

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

This review discusses the role of adjuvant treatment after curative surgery for patients with head and neck squamous cell carcinoma (HNSCC). In general, patients with unfavourable prognostic factors have a high-risk of loco-regional recurrence and subsequent worse survival after surgery alone and are therefore considered proper candidates for adjuvant treatment by either postoperative radiotherapy alone or postoperative chemoradiation. Selection of the most optimal adjuvant treatment strategy should be based on the most important prognostic factors. In this review, the different treatment strategies will be discussed in general. More specifically, we will discuss the role of the interval between surgery and radiotherapy, the overall treatment time of radiation, the selection of target volumes for radiation and the value of adding concomitant chemotherapy to postoperative radiation.

Original languageEnglish (US)
Pages (from-to)577-585
Number of pages9
JournalOral Oncology
Volume46
Issue number8
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

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Radiation
Radiotherapy
Therapeutics
Carcinoma, squamous cell of head and neck
Recurrence
Drug Therapy
Survival

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

Langendijk, J. A., Ferlito, A., Takes, R. P., Rodrigo, J. P., Suárez, C., Strojan, P., ... Rinaldo, A. (2010). Postoperative strategies after primary surgery for squamous cell carcinoma of the head and neck. Oral Oncology, 46(8), 577-585. https://doi.org/10.1016/j.oraloncology.2010.03.023
Langendijk, Johannes A. ; Ferlito, Alfio ; Takes, Robert P. ; Rodrigo, Juan P. ; Suárez, Carl ; Strojan, Primo ; Haigentz, Missak ; Rinaldo, Alessandra. / Postoperative strategies after primary surgery for squamous cell carcinoma of the head and neck. In: Oral Oncology. 2010 ; Vol. 46, No. 8. pp. 577-585.
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Langendijk, JA, Ferlito, A, Takes, RP, Rodrigo, JP, Suárez, C, Strojan, P, Haigentz, M & Rinaldo, A 2010, 'Postoperative strategies after primary surgery for squamous cell carcinoma of the head and neck', Oral Oncology, vol. 46, no. 8, pp. 577-585. https://doi.org/10.1016/j.oraloncology.2010.03.023

Postoperative strategies after primary surgery for squamous cell carcinoma of the head and neck. / Langendijk, Johannes A.; Ferlito, Alfio; Takes, Robert P.; Rodrigo, Juan P.; Suárez, Carl; Strojan, Primo; Haigentz, Missak; Rinaldo, Alessandra.

In: Oral Oncology, Vol. 46, No. 8, 01.08.2010, p. 577-585.

Research output: Contribution to journalReview article

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AU - Rinaldo, Alessandra

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Langendijk JA, Ferlito A, Takes RP, Rodrigo JP, Suárez C, Strojan P et al. Postoperative strategies after primary surgery for squamous cell carcinoma of the head and neck. Oral Oncology. 2010 Aug 1;46(8):577-585. https://doi.org/10.1016/j.oraloncology.2010.03.023