Portal vein involvement in pancreatic cancer

a sign of unresectability?

Lawrence Harrison, M. F. Brennan

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Although the prognosis remains poor, surgical exploration with complete resection provides the only potential cure for patients with adenocarcinoma of the pancreas. However, only 15% to 20% of patients are candidates for resection because of the presence of distant tumor outside the confines of resection or because of locally advanced disease. Even though isolated portal vein involvement has classically been a contraindication for resection, PVR can be performed safely with a low perioperative mortality rate. Besides PV involvement and size, the distribution of histopathologic prognostic factors is no different between patients undergoing PVR and those undergoing standard pancreatic resection. Importantly, overall survival is similar between both groups. Therefore, suspected isolated PV involvement frequently does not preclude operability and, by itself, should not be a contraindication to pancreatic resection.

Original languageEnglish (US)
Pages (from-to)375-394
Number of pages20
JournalAdvances in surgery
Volume31
StatePublished - Jan 1 1997

Fingerprint

Portal Vein
Pancreatic Neoplasms
Pancreas
Adenocarcinoma
Survival
Mortality
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

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title = "Portal vein involvement in pancreatic cancer: a sign of unresectability?",
abstract = "Although the prognosis remains poor, surgical exploration with complete resection provides the only potential cure for patients with adenocarcinoma of the pancreas. However, only 15{\%} to 20{\%} of patients are candidates for resection because of the presence of distant tumor outside the confines of resection or because of locally advanced disease. Even though isolated portal vein involvement has classically been a contraindication for resection, PVR can be performed safely with a low perioperative mortality rate. Besides PV involvement and size, the distribution of histopathologic prognostic factors is no different between patients undergoing PVR and those undergoing standard pancreatic resection. Importantly, overall survival is similar between both groups. Therefore, suspected isolated PV involvement frequently does not preclude operability and, by itself, should not be a contraindication to pancreatic resection.",
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Portal vein involvement in pancreatic cancer : a sign of unresectability? / Harrison, Lawrence; Brennan, M. F.

In: Advances in surgery, Vol. 31, 01.01.1997, p. 375-394.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Portal vein involvement in pancreatic cancer

T2 - a sign of unresectability?

AU - Harrison, Lawrence

AU - Brennan, M. F.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Although the prognosis remains poor, surgical exploration with complete resection provides the only potential cure for patients with adenocarcinoma of the pancreas. However, only 15% to 20% of patients are candidates for resection because of the presence of distant tumor outside the confines of resection or because of locally advanced disease. Even though isolated portal vein involvement has classically been a contraindication for resection, PVR can be performed safely with a low perioperative mortality rate. Besides PV involvement and size, the distribution of histopathologic prognostic factors is no different between patients undergoing PVR and those undergoing standard pancreatic resection. Importantly, overall survival is similar between both groups. Therefore, suspected isolated PV involvement frequently does not preclude operability and, by itself, should not be a contraindication to pancreatic resection.

AB - Although the prognosis remains poor, surgical exploration with complete resection provides the only potential cure for patients with adenocarcinoma of the pancreas. However, only 15% to 20% of patients are candidates for resection because of the presence of distant tumor outside the confines of resection or because of locally advanced disease. Even though isolated portal vein involvement has classically been a contraindication for resection, PVR can be performed safely with a low perioperative mortality rate. Besides PV involvement and size, the distribution of histopathologic prognostic factors is no different between patients undergoing PVR and those undergoing standard pancreatic resection. Importantly, overall survival is similar between both groups. Therefore, suspected isolated PV involvement frequently does not preclude operability and, by itself, should not be a contraindication to pancreatic resection.

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M3 - Review article

VL - 31

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