Pericardial effusion post-SCT in pediatric recipients with signs and/or symptoms of cardiac disease

Michelle Neier, Z. Jin, C. Kleinman, L. Baldinger, M. Bhatia, E. Silver, C. Van De Ven, E. Morris, P. Satwani, D. George, J. Garvin, M. B. Bradley, J. Schwartz, M. S. Cairo

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Abstract

The objective of this study was to assess the incidence, risk factors, outcome and impact on OS of pericardial effusion (PEF) in a cohort of 156 pediatric SCT recipients. The mean age was 8.15±6.25 years. In all, 74% of the patients had malignant disease and 35% of the patients received autologous stem cell grafts. Twenty-three subjects developed effusion at 2.75±3.54 months after SCT. The overall probability of developing a PEF after SCT was 16.9%. In the multivariate analysis of risk factors associated with time to PEF, increased age, allogeneic risk status and conditioning type, were all significant factors. In a multivariate analysis of time to death, PEF, CMV status and risk status were all independent risk factors. PEF, however, had the highest HR of 3.334. Of the 23 patients with PEF, 19 died (82.6%); however, none died as a direct result of pericardial tamponade. In summary, our results suggest that PEF is a significant risk factor for post transplant mortality. These results suggest a need for more frequent evaluation and monitoring for development of PEF. Studies are needed to determine the etiology of, and new therapeutic strategies for, PEF in the post-SCT population.

Original languageEnglish (US)
Pages (from-to)529-538
Number of pages10
JournalBone Marrow Transplantation
Volume46
Issue number4
DOIs
StatePublished - Apr 1 2011

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Pericardial Effusion
Signs and Symptoms
Heart Diseases
Pediatrics
Multivariate Analysis
Transplants
Cardiac Tamponade
Stem Cells
Mortality
Incidence

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

Neier, Michelle ; Jin, Z. ; Kleinman, C. ; Baldinger, L. ; Bhatia, M. ; Silver, E. ; Van De Ven, C. ; Morris, E. ; Satwani, P. ; George, D. ; Garvin, J. ; Bradley, M. B. ; Schwartz, J. ; Cairo, M. S. / Pericardial effusion post-SCT in pediatric recipients with signs and/or symptoms of cardiac disease. In: Bone Marrow Transplantation. 2011 ; Vol. 46, No. 4. pp. 529-538.
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Neier, M, Jin, Z, Kleinman, C, Baldinger, L, Bhatia, M, Silver, E, Van De Ven, C, Morris, E, Satwani, P, George, D, Garvin, J, Bradley, MB, Schwartz, J & Cairo, MS 2011, 'Pericardial effusion post-SCT in pediatric recipients with signs and/or symptoms of cardiac disease', Bone Marrow Transplantation, vol. 46, no. 4, pp. 529-538. https://doi.org/10.1038/bmt.2010.149

Pericardial effusion post-SCT in pediatric recipients with signs and/or symptoms of cardiac disease. / Neier, Michelle; Jin, Z.; Kleinman, C.; Baldinger, L.; Bhatia, M.; Silver, E.; Van De Ven, C.; Morris, E.; Satwani, P.; George, D.; Garvin, J.; Bradley, M. B.; Schwartz, J.; Cairo, M. S.

In: Bone Marrow Transplantation, Vol. 46, No. 4, 01.04.2011, p. 529-538.

Research output: Contribution to journalArticle

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AU - Neier, Michelle

AU - Jin, Z.

AU - Kleinman, C.

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AU - Bhatia, M.

AU - Silver, E.

AU - Van De Ven, C.

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AU - Satwani, P.

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AU - Garvin, J.

AU - Bradley, M. B.

AU - Schwartz, J.

AU - Cairo, M. S.

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