Paravalvular leak after transcatheter aortic valve replacement: The new achilles' heel? A comprehensive review of the literature

Philippe Généreux, Stuart J. Head, Rebecca Hahn, Benoit Daneault, Susheel Kodali, Mathew R. Williams, Nicolas M. Van Mieghem, Maria C. Alu, Patrick W. Serruys, A. Pieter Kappetein, Martin B. Leon

Research output: Contribution to journalReview article

248 Citations (Scopus)

Abstract

Paravalvular leak (PVL) is a frequent complication of transcatheter aortic valve replacement (TAVR) and is seen at a much higher rate after TAVR than after conventional surgical aortic valve replacement. Recent reports indicating that PVL may be correlated with increased late mortality have raised concerns. However, the heterogeneity of Methods: for assessing and quantifying PVL, and lack of consistency in the timing of such assessments, is a hindrance to understanding its true prevalence, severity, and effect. This literature review is an effort to consolidate current knowledge in this area to better understand the prevalence, progression, and impact of post-TAVR PVL and to help direct future efforts regarding the assessment, prevention, and treatment of this troublesome complication.

Original languageEnglish (US)
Pages (from-to)1125-1136
Number of pages12
JournalJournal of the American College of Cardiology
Volume61
Issue number11
DOIs
StatePublished - Mar 19 2013
Externally publishedYes

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Aortic Valve
Surgical Instruments
Mortality
Transcatheter Aortic Valve Replacement

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Généreux, Philippe ; Head, Stuart J. ; Hahn, Rebecca ; Daneault, Benoit ; Kodali, Susheel ; Williams, Mathew R. ; Van Mieghem, Nicolas M. ; Alu, Maria C. ; Serruys, Patrick W. ; Kappetein, A. Pieter ; Leon, Martin B. / Paravalvular leak after transcatheter aortic valve replacement : The new achilles' heel? A comprehensive review of the literature. In: Journal of the American College of Cardiology. 2013 ; Vol. 61, No. 11. pp. 1125-1136.
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abstract = "Paravalvular leak (PVL) is a frequent complication of transcatheter aortic valve replacement (TAVR) and is seen at a much higher rate after TAVR than after conventional surgical aortic valve replacement. Recent reports indicating that PVL may be correlated with increased late mortality have raised concerns. However, the heterogeneity of Methods: for assessing and quantifying PVL, and lack of consistency in the timing of such assessments, is a hindrance to understanding its true prevalence, severity, and effect. This literature review is an effort to consolidate current knowledge in this area to better understand the prevalence, progression, and impact of post-TAVR PVL and to help direct future efforts regarding the assessment, prevention, and treatment of this troublesome complication.",
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Généreux, P, Head, SJ, Hahn, R, Daneault, B, Kodali, S, Williams, MR, Van Mieghem, NM, Alu, MC, Serruys, PW, Kappetein, AP & Leon, MB 2013, 'Paravalvular leak after transcatheter aortic valve replacement: The new achilles' heel? A comprehensive review of the literature', Journal of the American College of Cardiology, vol. 61, no. 11, pp. 1125-1136. https://doi.org/10.1016/j.jacc.2012.08.1039

Paravalvular leak after transcatheter aortic valve replacement : The new achilles' heel? A comprehensive review of the literature. / Généreux, Philippe; Head, Stuart J.; Hahn, Rebecca; Daneault, Benoit; Kodali, Susheel; Williams, Mathew R.; Van Mieghem, Nicolas M.; Alu, Maria C.; Serruys, Patrick W.; Kappetein, A. Pieter; Leon, Martin B.

In: Journal of the American College of Cardiology, Vol. 61, No. 11, 19.03.2013, p. 1125-1136.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Paravalvular leak after transcatheter aortic valve replacement

T2 - The new achilles' heel? A comprehensive review of the literature

AU - Généreux, Philippe

AU - Head, Stuart J.

AU - Hahn, Rebecca

AU - Daneault, Benoit

AU - Kodali, Susheel

AU - Williams, Mathew R.

AU - Van Mieghem, Nicolas M.

AU - Alu, Maria C.

AU - Serruys, Patrick W.

AU - Kappetein, A. Pieter

AU - Leon, Martin B.

PY - 2013/3/19

Y1 - 2013/3/19

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AB - Paravalvular leak (PVL) is a frequent complication of transcatheter aortic valve replacement (TAVR) and is seen at a much higher rate after TAVR than after conventional surgical aortic valve replacement. Recent reports indicating that PVL may be correlated with increased late mortality have raised concerns. However, the heterogeneity of Methods: for assessing and quantifying PVL, and lack of consistency in the timing of such assessments, is a hindrance to understanding its true prevalence, severity, and effect. This literature review is an effort to consolidate current knowledge in this area to better understand the prevalence, progression, and impact of post-TAVR PVL and to help direct future efforts regarding the assessment, prevention, and treatment of this troublesome complication.

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