Paravalvular leak after transcatheter aortic valve replacement

P. Généreux, S. Kodali, R. Hahn, T. Nazif, M. R. Williams, M. B. Leon

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Paravalvular leak (PVL) is a frequent complication of transcatheter aortic valve replacement (TAVR) that occurs at a much higher rate after TAVR than after conventional surgical aortic valve replacement. Recent reports indicating that PVL may be associated with increased late mortality have raised significant concern. However, the heterogeneity of methods for assessing and quantifying PVL, in addition to lack of consistency in the timing of this assessment, complicate the understanding of its true prevalence, severity, and clinical implications. The following review is an effort to consolidate current knowledge in this area in order to better understand the incidence, progression, and clinical impact of post-TAVR PVL, as well as to focus future research efforts on the assessment, prevention, and treatment of this important complication.

Original languageEnglish (US)
Pages (from-to)529-537
Number of pages9
JournalMinerva Cardioangiologica
Volume61
Issue number5
StatePublished - Oct 1 2013
Externally publishedYes

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Aortic Valve
Surgical Instruments
Mortality
Incidence
Transcatheter Aortic Valve Replacement

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Généreux, P., Kodali, S., Hahn, R., Nazif, T., Williams, M. R., & Leon, M. B. (2013). Paravalvular leak after transcatheter aortic valve replacement. Minerva Cardioangiologica, 61(5), 529-537.
Généreux, P. ; Kodali, S. ; Hahn, R. ; Nazif, T. ; Williams, M. R. ; Leon, M. B. / Paravalvular leak after transcatheter aortic valve replacement. In: Minerva Cardioangiologica. 2013 ; Vol. 61, No. 5. pp. 529-537.
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Généreux, P, Kodali, S, Hahn, R, Nazif, T, Williams, MR & Leon, MB 2013, 'Paravalvular leak after transcatheter aortic valve replacement', Minerva Cardioangiologica, vol. 61, no. 5, pp. 529-537.

Paravalvular leak after transcatheter aortic valve replacement. / Généreux, P.; Kodali, S.; Hahn, R.; Nazif, T.; Williams, M. R.; Leon, M. B.

In: Minerva Cardioangiologica, Vol. 61, No. 5, 01.10.2013, p. 529-537.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Paravalvular leak after transcatheter aortic valve replacement

AU - Généreux, P.

AU - Kodali, S.

AU - Hahn, R.

AU - Nazif, T.

AU - Williams, M. R.

AU - Leon, M. B.

PY - 2013/10/1

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N2 - Paravalvular leak (PVL) is a frequent complication of transcatheter aortic valve replacement (TAVR) that occurs at a much higher rate after TAVR than after conventional surgical aortic valve replacement. Recent reports indicating that PVL may be associated with increased late mortality have raised significant concern. However, the heterogeneity of methods for assessing and quantifying PVL, in addition to lack of consistency in the timing of this assessment, complicate the understanding of its true prevalence, severity, and clinical implications. The following review is an effort to consolidate current knowledge in this area in order to better understand the incidence, progression, and clinical impact of post-TAVR PVL, as well as to focus future research efforts on the assessment, prevention, and treatment of this important complication.

AB - Paravalvular leak (PVL) is a frequent complication of transcatheter aortic valve replacement (TAVR) that occurs at a much higher rate after TAVR than after conventional surgical aortic valve replacement. Recent reports indicating that PVL may be associated with increased late mortality have raised significant concern. However, the heterogeneity of methods for assessing and quantifying PVL, in addition to lack of consistency in the timing of this assessment, complicate the understanding of its true prevalence, severity, and clinical implications. The following review is an effort to consolidate current knowledge in this area in order to better understand the incidence, progression, and clinical impact of post-TAVR PVL, as well as to focus future research efforts on the assessment, prevention, and treatment of this important complication.

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Généreux P, Kodali S, Hahn R, Nazif T, Williams MR, Leon MB. Paravalvular leak after transcatheter aortic valve replacement. Minerva Cardioangiologica. 2013 Oct 1;61(5):529-537.