Paraneoplastic and related forms of encephalitis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer affects the nervous system in a myriad of ways. Most common by far is direct invasion-of either the central or peripheral nervous system-either by contiguous spread or by metastatic disease. However, it has long been recognized (1) that nervous system function can be affected in patients with cancer in the absence of direct nervous system invasion-even before the cancer is diagnosed. Such remote effects of cancer can be biochemical, such as confusion or somnolence associated with hyponatremia in a lung cancer patient with the syndrome of inappropriate antidiuretic hormone secretion. It may be more directly hormonal-such as the myopathy associated with a cortisol secreting adenoma. Most intriguing are those disorders that are now known to be immune mediated, in which the immune response elicited by the tumor also recognizes neural antigens and triggers immune-mediated damage to the nervous system. The term “paraneoplastic neurologic disorder” is used primarily to describe these immune-mediated, cancer-triggered, remote nervous system abnormalities.

Original languageEnglish (US)
Title of host publicationEncephalitis
Subtitle of host publicationDiagnosis and Treatment
PublisherCRC Press
Pages321-333
Number of pages13
ISBN (Electronic)9781420013979
ISBN (Print)9780849340314
StatePublished - Jan 1 2007
Externally publishedYes

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Encephalitis
Nervous System
Neoplasms
Nervous System Malformations
Inappropriate ADH Syndrome
Hyponatremia
Peripheral Nervous System
Muscular Diseases
Nervous System Diseases
Adenoma
Hydrocortisone
Lung Neoplasms
Central Nervous System
Antigens

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Halperin, J., & Politsky, J. (2007). Paraneoplastic and related forms of encephalitis. In Encephalitis: Diagnosis and Treatment (pp. 321-333). CRC Press.
Halperin, John ; Politsky, Jeffrey. / Paraneoplastic and related forms of encephalitis. Encephalitis: Diagnosis and Treatment. CRC Press, 2007. pp. 321-333
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Halperin, J & Politsky, J 2007, Paraneoplastic and related forms of encephalitis. in Encephalitis: Diagnosis and Treatment. CRC Press, pp. 321-333.

Paraneoplastic and related forms of encephalitis. / Halperin, John; Politsky, Jeffrey.

Encephalitis: Diagnosis and Treatment. CRC Press, 2007. p. 321-333.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Halperin J, Politsky J. Paraneoplastic and related forms of encephalitis. In Encephalitis: Diagnosis and Treatment. CRC Press. 2007. p. 321-333