Orbital inflammatory disease: Unusual presentation of enthesitis in an HLA-B27 spondyloarthropathy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Orbital inflammatory disease can complicate many systemic inflammatory disorders, including sarcoidosis, vasculitis, Crohn's disease, systemic lupus erythematosus, rheumatoid arthritis, myasthenia gravis and scleroderma, but has not been reported with spondyloarthropathies. Observations: The authors describe a 29-year-old woman who developed orbital myositis, in addition to anterior uveitis, sacroiliitis and peripheral arthritis, as a complication of an underlying HLA-B27 related spondyloarthropathy, which responded temporarily to corticosteroid therapy and more completely to adalimumab. Conclusions: The patient reported herein presents with orbital inflammation as an extra-articular manifestation of HLA-B27 associated undifferentiated spondyloarthropathy. We propose that enthesitis is the likely mechanism of orbital inflammation in this patient.

Original languageEnglish (US)
Pages (from-to)468-470
Number of pages3
JournalOcular Immunology and Inflammation
Volume20
Issue number6
DOIs
StatePublished - Dec 1 2012

Fingerprint

Orbital Diseases
Spondylarthropathies
HLA-B27 Antigen
Orbital Myositis
Sacroiliitis
Inflammation
Anterior Uveitis
Myasthenia Gravis
Sarcoidosis
Vasculitis
Crohn Disease
Systemic Lupus Erythematosus
Arthritis
Rheumatoid Arthritis
Adrenal Cortex Hormones
Joints
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Ophthalmology

Cite this

@article{7a1daf81f58542ffac209549b53ca4e6,
title = "Orbital inflammatory disease: Unusual presentation of enthesitis in an HLA-B27 spondyloarthropathy",
abstract = "Background: Orbital inflammatory disease can complicate many systemic inflammatory disorders, including sarcoidosis, vasculitis, Crohn's disease, systemic lupus erythematosus, rheumatoid arthritis, myasthenia gravis and scleroderma, but has not been reported with spondyloarthropathies. Observations: The authors describe a 29-year-old woman who developed orbital myositis, in addition to anterior uveitis, sacroiliitis and peripheral arthritis, as a complication of an underlying HLA-B27 related spondyloarthropathy, which responded temporarily to corticosteroid therapy and more completely to adalimumab. Conclusions: The patient reported herein presents with orbital inflammation as an extra-articular manifestation of HLA-B27 associated undifferentiated spondyloarthropathy. We propose that enthesitis is the likely mechanism of orbital inflammation in this patient.",
author = "Amrita Sachdeva and Neil Kramer and Rosenstein, {Elliot D.}",
year = "2012",
month = "12",
day = "1",
doi = "10.3109/09273948.2012.723779",
language = "English (US)",
volume = "20",
pages = "468--470",
journal = "Ocular Immunology and Inflammation",
issn = "0927-3948",
publisher = "Informa Healthcare",
number = "6",

}

Orbital inflammatory disease : Unusual presentation of enthesitis in an HLA-B27 spondyloarthropathy. / Sachdeva, Amrita; Kramer, Neil; Rosenstein, Elliot D.

In: Ocular Immunology and Inflammation, Vol. 20, No. 6, 01.12.2012, p. 468-470.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Orbital inflammatory disease

T2 - Unusual presentation of enthesitis in an HLA-B27 spondyloarthropathy

AU - Sachdeva, Amrita

AU - Kramer, Neil

AU - Rosenstein, Elliot D.

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Background: Orbital inflammatory disease can complicate many systemic inflammatory disorders, including sarcoidosis, vasculitis, Crohn's disease, systemic lupus erythematosus, rheumatoid arthritis, myasthenia gravis and scleroderma, but has not been reported with spondyloarthropathies. Observations: The authors describe a 29-year-old woman who developed orbital myositis, in addition to anterior uveitis, sacroiliitis and peripheral arthritis, as a complication of an underlying HLA-B27 related spondyloarthropathy, which responded temporarily to corticosteroid therapy and more completely to adalimumab. Conclusions: The patient reported herein presents with orbital inflammation as an extra-articular manifestation of HLA-B27 associated undifferentiated spondyloarthropathy. We propose that enthesitis is the likely mechanism of orbital inflammation in this patient.

AB - Background: Orbital inflammatory disease can complicate many systemic inflammatory disorders, including sarcoidosis, vasculitis, Crohn's disease, systemic lupus erythematosus, rheumatoid arthritis, myasthenia gravis and scleroderma, but has not been reported with spondyloarthropathies. Observations: The authors describe a 29-year-old woman who developed orbital myositis, in addition to anterior uveitis, sacroiliitis and peripheral arthritis, as a complication of an underlying HLA-B27 related spondyloarthropathy, which responded temporarily to corticosteroid therapy and more completely to adalimumab. Conclusions: The patient reported herein presents with orbital inflammation as an extra-articular manifestation of HLA-B27 associated undifferentiated spondyloarthropathy. We propose that enthesitis is the likely mechanism of orbital inflammation in this patient.

UR - http://www.scopus.com/inward/record.url?scp=84870953944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870953944&partnerID=8YFLogxK

U2 - 10.3109/09273948.2012.723779

DO - 10.3109/09273948.2012.723779

M3 - Article

C2 - 23163732

AN - SCOPUS:84870953944

VL - 20

SP - 468

EP - 470

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

SN - 0927-3948

IS - 6

ER -