Oral vs repository corticosteroid therapy in acute asthma

I. B. Hoffman, Stanley Fiel

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Acutely ill asthmatic patients treated in the usual fashion in an emergency room setting and discharged within six hours were studied to determine whether therapy with a single injection of a repository corticosteroid (methylprednisolone sodum acetate) could be as effective as a tapering course of oral corticosteroids in decreasing asthma symptomatology and relapse within seven days. Seventeen patients (18 episodes of asthma) formed the study population. Eight episodes occurred in patients who received depot methylprednisolone (group 1) and ten episodes in patients who received oral corticosteroid treatment (group 2). All patients in both groups improved following emergency room treatment. Relapse occurred in two of ten patients in group 2 and none in group 1. Symptoms attributable to asthma recurred in significantly more patients in group 2 than in group 1 (9 vs 0, p<.01). Side effects from therapy with corticosteroids were rare. This study indicates that intramuscular repository corticosteroids are at least as effective as oral corticosteroids are at least as effective as oral corticosteroids in the management of the acute asthmatic outpatient, with a distinct advantage with regard to patient compliance.

Original languageEnglish (US)
Pages (from-to)11-13
Number of pages3
JournalChest
Volume93
Issue number1
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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Adrenal Cortex Hormones
Asthma
Therapeutics
Hospital Emergency Service
Recurrence
Emergency Treatment
Methylprednisolone
Patient Compliance
Outpatients
Injections
Population

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Hoffman, I. B. ; Fiel, Stanley. / Oral vs repository corticosteroid therapy in acute asthma. In: Chest. 1988 ; Vol. 93, No. 1. pp. 11-13.
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Oral vs repository corticosteroid therapy in acute asthma. / Hoffman, I. B.; Fiel, Stanley.

In: Chest, Vol. 93, No. 1, 01.01.1988, p. 11-13.

Research output: Contribution to journalArticle

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