Optimized" Delivery of Intracoronary Supersaturated Oxygen in Acute Anterior Myocardial Infarction: A feasibility and Safety Study

Ivan D. Hanson, Shukri W. David, Simon R. Dixon, D. Christopher Metzger, Philippe Généreux, Akiko Maehara, Ke Xu, Gregg W. Stone

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives We sought to evaluate the feasibility and safety of catheter-based supersaturated oxygen (SSO2) delivery via the left main coronary artery (LMCA) following primary percutaneous coronary intervention (PCI). Background: In the multicenter, randomized AMIHOT-II trial, SSO2 delivered into the proximal or mid left anterior descending (LAD) artery via an indwelling intracoronary infusion catheter in patients with acute anterior ST-segment elevation myocardial infarction (STEMI) following primary PCI significantly reduced infarct size but resulted in a numerically higher incidence of safety events. Methods: Patients with acute anterior STEMI presenting within 6 hr of symptom onset were enrolled at three centers. Following successful LAD stenting, SSO2 was infused into the LMCA via a diagnostic catheter for 60 min. The primary safety endpoint was the 30-day rate of target vessel failure (composite of death, reinfarction, or target vessel revascularization). Cardiac magnetic resonance imaging (cMRI) was performed at 3-5 and 30 days to assess infarct size. Results: Twenty patients with acute anterior STEMI were enrolled. The infarct lesion was located in the proximal LAD in 7 cases (35%) and the mid LAD in 13 cases (65%). Following primary PCI, SSO2 was delivered successfully in all cases. Target vessel failure within 30 days occurred in 1 patient (5%). Median [interquartile range] infarct size was 13.7% [5.4-20.6%] at 3-5 days and 9.6% [2.1-14.5%] at 30 days. Conclusions: Following primary PCI in acute anterior STEMI, infusion of SSO2 via the LMCA is feasible, and is associated with a favorable early safety and efficacy profile.

Original languageEnglish (US)
Pages (from-to)S51-S57
JournalCatheterization and Cardiovascular Interventions
Volume86
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Fingerprint

Feasibility Studies
Percutaneous Coronary Intervention
Myocardial Infarction
Oxygen
Safety
Coronary Vessels
Catheters
Arteries
Magnetic Resonance Imaging
Incidence

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Hanson, Ivan D. ; David, Shukri W. ; Dixon, Simon R. ; Metzger, D. Christopher ; Généreux, Philippe ; Maehara, Akiko ; Xu, Ke ; Stone, Gregg W. / Optimized" Delivery of Intracoronary Supersaturated Oxygen in Acute Anterior Myocardial Infarction : A feasibility and Safety Study. In: Catheterization and Cardiovascular Interventions. 2015 ; Vol. 86. pp. S51-S57.
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title = "Optimized{"} Delivery of Intracoronary Supersaturated Oxygen in Acute Anterior Myocardial Infarction: A feasibility and Safety Study",
abstract = "Objectives We sought to evaluate the feasibility and safety of catheter-based supersaturated oxygen (SSO2) delivery via the left main coronary artery (LMCA) following primary percutaneous coronary intervention (PCI). Background: In the multicenter, randomized AMIHOT-II trial, SSO2 delivered into the proximal or mid left anterior descending (LAD) artery via an indwelling intracoronary infusion catheter in patients with acute anterior ST-segment elevation myocardial infarction (STEMI) following primary PCI significantly reduced infarct size but resulted in a numerically higher incidence of safety events. Methods: Patients with acute anterior STEMI presenting within 6 hr of symptom onset were enrolled at three centers. Following successful LAD stenting, SSO2 was infused into the LMCA via a diagnostic catheter for 60 min. The primary safety endpoint was the 30-day rate of target vessel failure (composite of death, reinfarction, or target vessel revascularization). Cardiac magnetic resonance imaging (cMRI) was performed at 3-5 and 30 days to assess infarct size. Results: Twenty patients with acute anterior STEMI were enrolled. The infarct lesion was located in the proximal LAD in 7 cases (35{\%}) and the mid LAD in 13 cases (65{\%}). Following primary PCI, SSO2 was delivered successfully in all cases. Target vessel failure within 30 days occurred in 1 patient (5{\%}). Median [interquartile range] infarct size was 13.7{\%} [5.4-20.6{\%}] at 3-5 days and 9.6{\%} [2.1-14.5{\%}] at 30 days. Conclusions: Following primary PCI in acute anterior STEMI, infusion of SSO2 via the LMCA is feasible, and is associated with a favorable early safety and efficacy profile.",
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Optimized" Delivery of Intracoronary Supersaturated Oxygen in Acute Anterior Myocardial Infarction : A feasibility and Safety Study. / Hanson, Ivan D.; David, Shukri W.; Dixon, Simon R.; Metzger, D. Christopher; Généreux, Philippe; Maehara, Akiko; Xu, Ke; Stone, Gregg W.

In: Catheterization and Cardiovascular Interventions, Vol. 86, 01.10.2015, p. S51-S57.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Optimized" Delivery of Intracoronary Supersaturated Oxygen in Acute Anterior Myocardial Infarction

T2 - A feasibility and Safety Study

AU - Hanson, Ivan D.

AU - David, Shukri W.

AU - Dixon, Simon R.

AU - Metzger, D. Christopher

AU - Généreux, Philippe

AU - Maehara, Akiko

AU - Xu, Ke

AU - Stone, Gregg W.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Objectives We sought to evaluate the feasibility and safety of catheter-based supersaturated oxygen (SSO2) delivery via the left main coronary artery (LMCA) following primary percutaneous coronary intervention (PCI). Background: In the multicenter, randomized AMIHOT-II trial, SSO2 delivered into the proximal or mid left anterior descending (LAD) artery via an indwelling intracoronary infusion catheter in patients with acute anterior ST-segment elevation myocardial infarction (STEMI) following primary PCI significantly reduced infarct size but resulted in a numerically higher incidence of safety events. Methods: Patients with acute anterior STEMI presenting within 6 hr of symptom onset were enrolled at three centers. Following successful LAD stenting, SSO2 was infused into the LMCA via a diagnostic catheter for 60 min. The primary safety endpoint was the 30-day rate of target vessel failure (composite of death, reinfarction, or target vessel revascularization). Cardiac magnetic resonance imaging (cMRI) was performed at 3-5 and 30 days to assess infarct size. Results: Twenty patients with acute anterior STEMI were enrolled. The infarct lesion was located in the proximal LAD in 7 cases (35%) and the mid LAD in 13 cases (65%). Following primary PCI, SSO2 was delivered successfully in all cases. Target vessel failure within 30 days occurred in 1 patient (5%). Median [interquartile range] infarct size was 13.7% [5.4-20.6%] at 3-5 days and 9.6% [2.1-14.5%] at 30 days. Conclusions: Following primary PCI in acute anterior STEMI, infusion of SSO2 via the LMCA is feasible, and is associated with a favorable early safety and efficacy profile.

AB - Objectives We sought to evaluate the feasibility and safety of catheter-based supersaturated oxygen (SSO2) delivery via the left main coronary artery (LMCA) following primary percutaneous coronary intervention (PCI). Background: In the multicenter, randomized AMIHOT-II trial, SSO2 delivered into the proximal or mid left anterior descending (LAD) artery via an indwelling intracoronary infusion catheter in patients with acute anterior ST-segment elevation myocardial infarction (STEMI) following primary PCI significantly reduced infarct size but resulted in a numerically higher incidence of safety events. Methods: Patients with acute anterior STEMI presenting within 6 hr of symptom onset were enrolled at three centers. Following successful LAD stenting, SSO2 was infused into the LMCA via a diagnostic catheter for 60 min. The primary safety endpoint was the 30-day rate of target vessel failure (composite of death, reinfarction, or target vessel revascularization). Cardiac magnetic resonance imaging (cMRI) was performed at 3-5 and 30 days to assess infarct size. Results: Twenty patients with acute anterior STEMI were enrolled. The infarct lesion was located in the proximal LAD in 7 cases (35%) and the mid LAD in 13 cases (65%). Following primary PCI, SSO2 was delivered successfully in all cases. Target vessel failure within 30 days occurred in 1 patient (5%). Median [interquartile range] infarct size was 13.7% [5.4-20.6%] at 3-5 days and 9.6% [2.1-14.5%] at 30 days. Conclusions: Following primary PCI in acute anterior STEMI, infusion of SSO2 via the LMCA is feasible, and is associated with a favorable early safety and efficacy profile.

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