Nutrition, the gastrointestinal tract and the Acquired Immune Deficiency Syndrome. Facts and perspectives

P. Singer, M. M. Rothkopf, V. Kvetan, J. Gaare, L. Mello, J. Askanazi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Diarrhoea and malnutrition are common findings in patients with the Acquired Immune Deficiency Syndrome (AIDS). In this disease, enteropathy leads to fat and D-xylose malabsorption and chronic non-specific inflammation of the small bowel. Moreover, gastrointestinal infection can induce severe diarrhoea. Depletion in real body cell mass, body fat content, and weight loss have been observed. Nutritional therapy is mandatory when weight loss is 10% or greater. Enteral feeding is not easily achieved. Parenteral feeding including fat as a nonprotein calorie source improves general condition. The use of intravenous fat emulsions has been hypothesized to have several beneficial effects. Fluidisation of human immunodeficiency virus membranes by lipid emulsions through cholesterol extraction could decrease the infectivity of the virus. Long term intravenous nutrition may be more than a treatment for malabsorption and depletion; it may possibly have direct pharmacological effects.

Original languageEnglish (US)
Pages (from-to)281-287
Number of pages7
JournalClinical Nutrition
Volume8
Issue number6
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Gastrointestinal Tract
Weight Loss
Diarrhea
Acquired Immunodeficiency Syndrome
Intravenous Fat Emulsions
Fats
Xylose
Parenteral Nutrition
Enteral Nutrition
Membrane Lipids
Emulsions
Malnutrition
Adipose Tissue
Cholesterol
Body Weight
HIV
Pharmacology
Viruses
Inflammation
Therapeutics

All Science Journal Classification (ASJC) codes

  • Nutrition and Dietetics
  • Critical Care and Intensive Care Medicine

Cite this

Singer, P. ; Rothkopf, M. M. ; Kvetan, V. ; Gaare, J. ; Mello, L. ; Askanazi, J. / Nutrition, the gastrointestinal tract and the Acquired Immune Deficiency Syndrome. Facts and perspectives. In: Clinical Nutrition. 1989 ; Vol. 8, No. 6. pp. 281-287.
@article{cb7fd3c99f7c435c98ea99d49acf17ba,
title = "Nutrition, the gastrointestinal tract and the Acquired Immune Deficiency Syndrome. Facts and perspectives",
abstract = "Diarrhoea and malnutrition are common findings in patients with the Acquired Immune Deficiency Syndrome (AIDS). In this disease, enteropathy leads to fat and D-xylose malabsorption and chronic non-specific inflammation of the small bowel. Moreover, gastrointestinal infection can induce severe diarrhoea. Depletion in real body cell mass, body fat content, and weight loss have been observed. Nutritional therapy is mandatory when weight loss is 10{\%} or greater. Enteral feeding is not easily achieved. Parenteral feeding including fat as a nonprotein calorie source improves general condition. The use of intravenous fat emulsions has been hypothesized to have several beneficial effects. Fluidisation of human immunodeficiency virus membranes by lipid emulsions through cholesterol extraction could decrease the infectivity of the virus. Long term intravenous nutrition may be more than a treatment for malabsorption and depletion; it may possibly have direct pharmacological effects.",
author = "P. Singer and Rothkopf, {M. M.} and V. Kvetan and J. Gaare and L. Mello and J. Askanazi",
year = "1989",
month = "1",
day = "1",
doi = "10.1016/0261-5614(89)90002-2",
language = "English (US)",
volume = "8",
pages = "281--287",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Churchill Livingstone",
number = "6",

}

Nutrition, the gastrointestinal tract and the Acquired Immune Deficiency Syndrome. Facts and perspectives. / Singer, P.; Rothkopf, M. M.; Kvetan, V.; Gaare, J.; Mello, L.; Askanazi, J.

In: Clinical Nutrition, Vol. 8, No. 6, 01.01.1989, p. 281-287.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nutrition, the gastrointestinal tract and the Acquired Immune Deficiency Syndrome. Facts and perspectives

AU - Singer, P.

AU - Rothkopf, M. M.

AU - Kvetan, V.

AU - Gaare, J.

AU - Mello, L.

AU - Askanazi, J.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Diarrhoea and malnutrition are common findings in patients with the Acquired Immune Deficiency Syndrome (AIDS). In this disease, enteropathy leads to fat and D-xylose malabsorption and chronic non-specific inflammation of the small bowel. Moreover, gastrointestinal infection can induce severe diarrhoea. Depletion in real body cell mass, body fat content, and weight loss have been observed. Nutritional therapy is mandatory when weight loss is 10% or greater. Enteral feeding is not easily achieved. Parenteral feeding including fat as a nonprotein calorie source improves general condition. The use of intravenous fat emulsions has been hypothesized to have several beneficial effects. Fluidisation of human immunodeficiency virus membranes by lipid emulsions through cholesterol extraction could decrease the infectivity of the virus. Long term intravenous nutrition may be more than a treatment for malabsorption and depletion; it may possibly have direct pharmacological effects.

AB - Diarrhoea and malnutrition are common findings in patients with the Acquired Immune Deficiency Syndrome (AIDS). In this disease, enteropathy leads to fat and D-xylose malabsorption and chronic non-specific inflammation of the small bowel. Moreover, gastrointestinal infection can induce severe diarrhoea. Depletion in real body cell mass, body fat content, and weight loss have been observed. Nutritional therapy is mandatory when weight loss is 10% or greater. Enteral feeding is not easily achieved. Parenteral feeding including fat as a nonprotein calorie source improves general condition. The use of intravenous fat emulsions has been hypothesized to have several beneficial effects. Fluidisation of human immunodeficiency virus membranes by lipid emulsions through cholesterol extraction could decrease the infectivity of the virus. Long term intravenous nutrition may be more than a treatment for malabsorption and depletion; it may possibly have direct pharmacological effects.

UR - http://www.scopus.com/inward/record.url?scp=0024785580&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024785580&partnerID=8YFLogxK

U2 - 10.1016/0261-5614(89)90002-2

DO - 10.1016/0261-5614(89)90002-2

M3 - Article

C2 - 16837303

AN - SCOPUS:0024785580

VL - 8

SP - 281

EP - 287

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 6

ER -