Neurologic manifestations of neoplastic and radiation-induced plexopathies

Kurt A. Jaeckle

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

Metastatic plexopathy is often a disabling accompaniment of advanced systemic cancer, and may involve any of the peripheral nerve plexuses. Brachial plexopathy most commonly occurs in carcinoma of the breast and lung; lumbosacral plexopathy is most common with colorectal and gynecologic tumors, sarcomas, and lymphomas. Neoplastic plexopathy is often characterized initially by severe, unrelenting pain followed by development of weakness and focal sensory disturbances. In previously treated patients, the main differential diagnostic consideration is radiation-induced plexopathy, which can be difficult to distinguish from tumor plexopathy. Diagnosis is usually made following an analysis of the clinical, neuroimaging, and electrophysiologic features. Treatment of metastatic plexopathy has included surgical resection of tumor in selected cases, radiotherapy to the plexus, systemic chemotherapy, interventional pain management procedures, and symptomatic treatment. These measures often offer temporary (months) relief or improvement. Physicians treating these patients should focus on effective management of pain and prevention of complications of immobility produced by the neuromuscular dysfunction.

Original languageEnglish (US)
Pages (from-to)254-262
Number of pages9
JournalSeminars in Neurology
Volume30
Issue number3
DOIs
StatePublished - Jul 6 2010

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Neurologic Manifestations
Pain Management
Radiation
Brachial Plexus Neuropathies
Neoplasms
Peripheral Nerves
Neuroimaging
Sarcoma
Colorectal Neoplasms
Lymphoma
Radiotherapy
Breast Neoplasms
Physicians
Drug Therapy
Pain
Lung
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

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Neurologic manifestations of neoplastic and radiation-induced plexopathies. / Jaeckle, Kurt A.

In: Seminars in Neurology, Vol. 30, No. 3, 06.07.2010, p. 254-262.

Research output: Contribution to journalReview article

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