Abstract
Infection with the tick-borne spirochete, Borrelia burgdorferi, affects the nervous system in well-defined ways. Accurate diagnostic tools and effective therapeutic regimens are now well established. Persistent misconceptions about (1) the role and interpretation of laboratory tests, (2) what is and is not evidence of nervous system infection, and (3) what constitutes an expected response to treatment have fostered widespread perceptions that this disease is highly controversial. Infection causes the classically described triad of meningitis, radiculoneuritis, and cranial neuritis; however, virtually every known neurologic disorder has been blamed on this infection. For most (multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer disease, Parkinson disease), evidence is scant, nonexistent, or coincidental. For some (cerebral vasculitis with stroke, optic neuritis) a few case reports suggest a rare possible causal link.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 317-324 |
| Number of pages | 8 |
| Journal | Seminars in Neurology |
| Volume | 31 |
| Issue number | 3 |
| DOIs | |
| State | Published - Oct 11 2011 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
Cite this
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Nervous system Lyme disease : Is there a controversy? / Halperin, John J.
In: Seminars in Neurology, Vol. 31, No. 3, 11.10.2011, p. 317-324.Research output: Contribution to journal › Article
TY - JOUR
T1 - Nervous system Lyme disease
T2 - Is there a controversy?
AU - Halperin, John J.
PY - 2011/10/11
Y1 - 2011/10/11
N2 - Infection with the tick-borne spirochete, Borrelia burgdorferi, affects the nervous system in well-defined ways. Accurate diagnostic tools and effective therapeutic regimens are now well established. Persistent misconceptions about (1) the role and interpretation of laboratory tests, (2) what is and is not evidence of nervous system infection, and (3) what constitutes an expected response to treatment have fostered widespread perceptions that this disease is highly controversial. Infection causes the classically described triad of meningitis, radiculoneuritis, and cranial neuritis; however, virtually every known neurologic disorder has been blamed on this infection. For most (multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer disease, Parkinson disease), evidence is scant, nonexistent, or coincidental. For some (cerebral vasculitis with stroke, optic neuritis) a few case reports suggest a rare possible causal link.
AB - Infection with the tick-borne spirochete, Borrelia burgdorferi, affects the nervous system in well-defined ways. Accurate diagnostic tools and effective therapeutic regimens are now well established. Persistent misconceptions about (1) the role and interpretation of laboratory tests, (2) what is and is not evidence of nervous system infection, and (3) what constitutes an expected response to treatment have fostered widespread perceptions that this disease is highly controversial. Infection causes the classically described triad of meningitis, radiculoneuritis, and cranial neuritis; however, virtually every known neurologic disorder has been blamed on this infection. For most (multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer disease, Parkinson disease), evidence is scant, nonexistent, or coincidental. For some (cerebral vasculitis with stroke, optic neuritis) a few case reports suggest a rare possible causal link.
UR - http://www.scopus.com/inward/record.url?scp=80053503653&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053503653&partnerID=8YFLogxK
U2 - 10.1055/s-0031-1287652
DO - 10.1055/s-0031-1287652
M3 - Article
C2 - 21964848
AN - SCOPUS:80053503653
VL - 31
SP - 317
EP - 324
JO - Seminars in Neurology
JF - Seminars in Neurology
SN - 0271-8235
IS - 3
ER -