Abstract
Lymphocytic meningitis, cranial neuritis or radiculoneuritis occur in up to 15% of patients with untreated Borrelia burgdorferi infection. Presentations of multifocal PNS involvement can range from painful monoradiculitis to confluent mononeuropathy multiplex. Serologic testing is highly accurate after 4 to 6 weeks of infection. In CNS infection, production of anti-. B burgdorferi antibody is often demonstrable in CSF. Oral antimicrobials are microbiologically curative in virtually all patients, including acute European neuroborreliosis. Severe cases may require parenteral treatment. The fatigue and cognitive symptoms seen in some patients with extra-neurological disease are neither evidence of CNS infection nor specific to Lyme disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 241-253 |
| Number of pages | 13 |
| Journal | Infectious Disease Clinics of North America |
| Volume | 29 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2015 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases
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Nervous System Lyme Disease. / Halperin, John.
In: Infectious Disease Clinics of North America, Vol. 29, No. 2, 01.06.2015, p. 241-253.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Nervous System Lyme Disease
AU - Halperin, John
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Lymphocytic meningitis, cranial neuritis or radiculoneuritis occur in up to 15% of patients with untreated Borrelia burgdorferi infection. Presentations of multifocal PNS involvement can range from painful monoradiculitis to confluent mononeuropathy multiplex. Serologic testing is highly accurate after 4 to 6 weeks of infection. In CNS infection, production of anti-. B burgdorferi antibody is often demonstrable in CSF. Oral antimicrobials are microbiologically curative in virtually all patients, including acute European neuroborreliosis. Severe cases may require parenteral treatment. The fatigue and cognitive symptoms seen in some patients with extra-neurological disease are neither evidence of CNS infection nor specific to Lyme disease.
AB - Lymphocytic meningitis, cranial neuritis or radiculoneuritis occur in up to 15% of patients with untreated Borrelia burgdorferi infection. Presentations of multifocal PNS involvement can range from painful monoradiculitis to confluent mononeuropathy multiplex. Serologic testing is highly accurate after 4 to 6 weeks of infection. In CNS infection, production of anti-. B burgdorferi antibody is often demonstrable in CSF. Oral antimicrobials are microbiologically curative in virtually all patients, including acute European neuroborreliosis. Severe cases may require parenteral treatment. The fatigue and cognitive symptoms seen in some patients with extra-neurological disease are neither evidence of CNS infection nor specific to Lyme disease.
UR - http://www.scopus.com/inward/record.url?scp=84929610358&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929610358&partnerID=8YFLogxK
U2 - 10.1016/j.idc.2015.02.002
DO - 10.1016/j.idc.2015.02.002
M3 - Review article
C2 - 25999221
AN - SCOPUS:84929610358
VL - 29
SP - 241
EP - 253
JO - Infectious Disease Clinics of North America
JF - Infectious Disease Clinics of North America
SN - 0891-5520
IS - 2
ER -