Abstract
Objective. Nonsteroidal antiinflammatory drugs have been thought to act by inhibiting the enzyme, cyclooxygenase (prostaglandin H synthetase). We sought to demonstrate additional biologic actions of this class of drugs including effects on cytokine production. Methods. We administered the nonsteroidal antiinfiammatory drug piroxicarn 20 mg to 6 healthy volunteers daily for 7 days. Before and for one week after drug administration, concentrations of interleukin I (IL-1), IL-2, IL-4, IL-6, tumor necrosis factor α (TNFα) and interferon-γ (IFN-γ), produced by anti-CD3 stimulated peripheral blood mononuclear cells, were measured. Results. Piroxicam treatment resulted in elevation of levels of IL-2, depression of IL-1, IL-6, TNFα and IFN-γ, and no consistent effect on IL-4. Conclusion. Piroxicam modulates production of various cytokines in a complex fashion when administered to healthy individuals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 901-904 |
| Number of pages | 4 |
| Journal | Journal of Rheumatology |
| Volume | 21 |
| Issue number | 5 |
| State | Published - Jan 1 1994 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Immunology
- Rheumatology
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Modification of cytokine production by piroxicam. / Rosenstein, Elliot; Kunicka, J.; Kramer, Neil; Goldstein, G.
In: Journal of Rheumatology, Vol. 21, No. 5, 01.01.1994, p. 901-904.Research output: Contribution to journal › Article
TY - JOUR
T1 - Modification of cytokine production by piroxicam
AU - Rosenstein, Elliot
AU - Kunicka, J.
AU - Kramer, Neil
AU - Goldstein, G.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Objective. Nonsteroidal antiinflammatory drugs have been thought to act by inhibiting the enzyme, cyclooxygenase (prostaglandin H synthetase). We sought to demonstrate additional biologic actions of this class of drugs including effects on cytokine production. Methods. We administered the nonsteroidal antiinfiammatory drug piroxicarn 20 mg to 6 healthy volunteers daily for 7 days. Before and for one week after drug administration, concentrations of interleukin I (IL-1), IL-2, IL-4, IL-6, tumor necrosis factor α (TNFα) and interferon-γ (IFN-γ), produced by anti-CD3 stimulated peripheral blood mononuclear cells, were measured. Results. Piroxicam treatment resulted in elevation of levels of IL-2, depression of IL-1, IL-6, TNFα and IFN-γ, and no consistent effect on IL-4. Conclusion. Piroxicam modulates production of various cytokines in a complex fashion when administered to healthy individuals.
AB - Objective. Nonsteroidal antiinflammatory drugs have been thought to act by inhibiting the enzyme, cyclooxygenase (prostaglandin H synthetase). We sought to demonstrate additional biologic actions of this class of drugs including effects on cytokine production. Methods. We administered the nonsteroidal antiinfiammatory drug piroxicarn 20 mg to 6 healthy volunteers daily for 7 days. Before and for one week after drug administration, concentrations of interleukin I (IL-1), IL-2, IL-4, IL-6, tumor necrosis factor α (TNFα) and interferon-γ (IFN-γ), produced by anti-CD3 stimulated peripheral blood mononuclear cells, were measured. Results. Piroxicam treatment resulted in elevation of levels of IL-2, depression of IL-1, IL-6, TNFα and IFN-γ, and no consistent effect on IL-4. Conclusion. Piroxicam modulates production of various cytokines in a complex fashion when administered to healthy individuals.
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M3 - Article
VL - 21
SP - 901
EP - 904
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 5
ER -