Modification of cytokine production by piroxicam

Elliot Rosenstein, J. Kunicka, Neil Kramer, G. Goldstein

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective. Nonsteroidal antiinflammatory drugs have been thought to act by inhibiting the enzyme, cyclooxygenase (prostaglandin H synthetase). We sought to demonstrate additional biologic actions of this class of drugs including effects on cytokine production. Methods. We administered the nonsteroidal antiinfiammatory drug piroxicarn 20 mg to 6 healthy volunteers daily for 7 days. Before and for one week after drug administration, concentrations of interleukin I (IL-1), IL-2, IL-4, IL-6, tumor necrosis factor α (TNFα) and interferon-γ (IFN-γ), produced by anti-CD3 stimulated peripheral blood mononuclear cells, were measured. Results. Piroxicam treatment resulted in elevation of levels of IL-2, depression of IL-1, IL-6, TNFα and IFN-γ, and no consistent effect on IL-4. Conclusion. Piroxicam modulates production of various cytokines in a complex fashion when administered to healthy individuals.

Original languageEnglish (US)
Pages (from-to)901-904
Number of pages4
JournalJournal of Rheumatology
Volume21
Issue number5
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Piroxicam
Interleukin-1
Cytokines
Prostaglandin-Endoperoxide Synthases
Interleukin-4
Pharmaceutical Preparations
Interferons
Interleukin-2
Interleukin-6
Prostaglandins H
Tumor Necrosis Factor-alpha
Blood Cells
Healthy Volunteers
Anti-Inflammatory Agents
Enzymes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology
  • Rheumatology

Cite this

Rosenstein, Elliot ; Kunicka, J. ; Kramer, Neil ; Goldstein, G. / Modification of cytokine production by piroxicam. In: Journal of Rheumatology. 1994 ; Vol. 21, No. 5. pp. 901-904.
@article{cf3195040c8f474aa272f83d63671f15,
title = "Modification of cytokine production by piroxicam",
abstract = "Objective. Nonsteroidal antiinflammatory drugs have been thought to act by inhibiting the enzyme, cyclooxygenase (prostaglandin H synthetase). We sought to demonstrate additional biologic actions of this class of drugs including effects on cytokine production. Methods. We administered the nonsteroidal antiinfiammatory drug piroxicarn 20 mg to 6 healthy volunteers daily for 7 days. Before and for one week after drug administration, concentrations of interleukin I (IL-1), IL-2, IL-4, IL-6, tumor necrosis factor α (TNFα) and interferon-γ (IFN-γ), produced by anti-CD3 stimulated peripheral blood mononuclear cells, were measured. Results. Piroxicam treatment resulted in elevation of levels of IL-2, depression of IL-1, IL-6, TNFα and IFN-γ, and no consistent effect on IL-4. Conclusion. Piroxicam modulates production of various cytokines in a complex fashion when administered to healthy individuals.",
author = "Elliot Rosenstein and J. Kunicka and Neil Kramer and G. Goldstein",
year = "1994",
month = "1",
day = "1",
language = "English (US)",
volume = "21",
pages = "901--904",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "5",

}

Rosenstein, E, Kunicka, J, Kramer, N & Goldstein, G 1994, 'Modification of cytokine production by piroxicam', Journal of Rheumatology, vol. 21, no. 5, pp. 901-904.

Modification of cytokine production by piroxicam. / Rosenstein, Elliot; Kunicka, J.; Kramer, Neil; Goldstein, G.

In: Journal of Rheumatology, Vol. 21, No. 5, 01.01.1994, p. 901-904.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Modification of cytokine production by piroxicam

AU - Rosenstein, Elliot

AU - Kunicka, J.

AU - Kramer, Neil

AU - Goldstein, G.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Objective. Nonsteroidal antiinflammatory drugs have been thought to act by inhibiting the enzyme, cyclooxygenase (prostaglandin H synthetase). We sought to demonstrate additional biologic actions of this class of drugs including effects on cytokine production. Methods. We administered the nonsteroidal antiinfiammatory drug piroxicarn 20 mg to 6 healthy volunteers daily for 7 days. Before and for one week after drug administration, concentrations of interleukin I (IL-1), IL-2, IL-4, IL-6, tumor necrosis factor α (TNFα) and interferon-γ (IFN-γ), produced by anti-CD3 stimulated peripheral blood mononuclear cells, were measured. Results. Piroxicam treatment resulted in elevation of levels of IL-2, depression of IL-1, IL-6, TNFα and IFN-γ, and no consistent effect on IL-4. Conclusion. Piroxicam modulates production of various cytokines in a complex fashion when administered to healthy individuals.

AB - Objective. Nonsteroidal antiinflammatory drugs have been thought to act by inhibiting the enzyme, cyclooxygenase (prostaglandin H synthetase). We sought to demonstrate additional biologic actions of this class of drugs including effects on cytokine production. Methods. We administered the nonsteroidal antiinfiammatory drug piroxicarn 20 mg to 6 healthy volunteers daily for 7 days. Before and for one week after drug administration, concentrations of interleukin I (IL-1), IL-2, IL-4, IL-6, tumor necrosis factor α (TNFα) and interferon-γ (IFN-γ), produced by anti-CD3 stimulated peripheral blood mononuclear cells, were measured. Results. Piroxicam treatment resulted in elevation of levels of IL-2, depression of IL-1, IL-6, TNFα and IFN-γ, and no consistent effect on IL-4. Conclusion. Piroxicam modulates production of various cytokines in a complex fashion when administered to healthy individuals.

UR - http://www.scopus.com/inward/record.url?scp=0028237431&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028237431&partnerID=8YFLogxK

M3 - Article

VL - 21

SP - 901

EP - 904

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 5

ER -