Medical Treatment of Aortic Stenosis

Guillaume Marquis-Gravel, Björn Redfors, Martin B. Leon, Philippe Genereux

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Untreated, severe, symptomatic aortic stenosis is associated with a dismal prognosis. The only treatment shown to improve survival is aortic valve replacement; however, before symptoms occur, aortic stenosis is preceded by a silent, latent phase characterized by a slow progression at the molecular, cellular, and tissue levels. In theory, specific medical therapy should halt aortic stenosis progression, reduce its hemodynamic repercussions on left ventricular function and remodeling, and improve clinical outcomes. In the present report, we performed a systematic review of studies focusing on the medical treatment of patients with aortic stenosis. Lipid-lowering therapy, antihypertensive drugs, and anticalcific therapy have been the main drug classes studied in this setting and are reviewed in depth. A critical appraisal of the preclinical and clinical evidence is provided, and future research avenues are presented.

Original languageEnglish (US)
Pages (from-to)1766-1784
Number of pages19
JournalCirculation
Volume134
Issue number22
DOIs
StatePublished - Nov 29 2016
Externally publishedYes

Fingerprint

Aortic Valve Stenosis
Ventricular Remodeling
Therapeutics
Aortic Valve
Left Ventricular Function
Antihypertensive Agents
Hemodynamics
Lipids
Drug Therapy
Survival
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Marquis-Gravel, G., Redfors, B., Leon, M. B., & Genereux, P. (2016). Medical Treatment of Aortic Stenosis. Circulation, 134(22), 1766-1784. https://doi.org/10.1161/CIRCULATIONAHA.116.023997
Marquis-Gravel, Guillaume ; Redfors, Björn ; Leon, Martin B. ; Genereux, Philippe. / Medical Treatment of Aortic Stenosis. In: Circulation. 2016 ; Vol. 134, No. 22. pp. 1766-1784.
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Marquis-Gravel, G, Redfors, B, Leon, MB & Genereux, P 2016, 'Medical Treatment of Aortic Stenosis', Circulation, vol. 134, no. 22, pp. 1766-1784. https://doi.org/10.1161/CIRCULATIONAHA.116.023997

Medical Treatment of Aortic Stenosis. / Marquis-Gravel, Guillaume; Redfors, Björn; Leon, Martin B.; Genereux, Philippe.

In: Circulation, Vol. 134, No. 22, 29.11.2016, p. 1766-1784.

Research output: Contribution to journalArticle

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Marquis-Gravel G, Redfors B, Leon MB, Genereux P. Medical Treatment of Aortic Stenosis. Circulation. 2016 Nov 29;134(22):1766-1784. https://doi.org/10.1161/CIRCULATIONAHA.116.023997