Mathematical Model of the Roles of T Cells in Inflammatory Bowel Disease

Wing Cheong Lo, Razvan Arsenescu, Avner Friedman

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Gut mucosal homeostasis depends on complex interactions among the microbiota, the intestinal epithelium, and the gut associated immune system. A breakdown in some of these interactions may precipitate inflammation. Inflammatory bowel diseases, Crohn's disease, and ulcerative colitis are chronic inflammatory disorders of the gastrointestinal tract. The initial stages of disease are marked by an abnormally high level of pro-inflammatory helper T cells, Th1. In later stages, Th2 helper cells may dominate while the Th1 response may dampen. The interaction among the T cells includes the regulatory T cells (Treg). The present paper develops a mathematical model by a system of differential equations with terms nonlocal in the space spanned by the concentrations of cytokines that represents the interaction among T cells through a cytokine signaling network. The model demonstrates how the abnormal levels of T cells observed in inflammatory bowel diseases can arise from abnormal regulation of Th1 and Th2 cells by Treg cells.

Original languageEnglish (US)
Pages (from-to)1417-1433
Number of pages17
JournalBulletin of Mathematical Biology
Volume75
Issue number9
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

Fingerprint

T-cells
inflammatory bowel disease
Inflammatory Bowel Diseases
Th2 Cells
Theoretical Models
mathematical models
T-lymphocytes
Regulatory T-Lymphocytes
Mathematical Model
Mathematical models
Helper-Inducer T-Lymphocytes
T-Lymphocytes
Cytokines
Th1 Cells
Interaction
Microbiota
Intestinal Mucosa
Cell
Ulcerative Colitis
Crohn Disease

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Immunology
  • Mathematics(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Pharmacology
  • Agricultural and Biological Sciences(all)
  • Computational Theory and Mathematics

Cite this

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Mathematical Model of the Roles of T Cells in Inflammatory Bowel Disease. / Lo, Wing Cheong; Arsenescu, Razvan; Friedman, Avner.

In: Bulletin of Mathematical Biology, Vol. 75, No. 9, 01.09.2013, p. 1417-1433.

Research output: Contribution to journalArticle

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AU - Arsenescu, Razvan

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