Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?

Stuart E. Samuels, Avraham Eisbruch, Jonathan J. Beitler, June Corry, Carol R. Bradford, Nabil F. Saba, Michiel W.M. van den Brekel, Robert Smee, Primož Strojan, Carlos Suárez, William M. Mendenhall, Robert P. Takes, Juan P. Rodrigo, Missak Haigentz, Alexander D. Rapidis, Alessandra Rinaldo, Alfio Ferlito

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV−) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.

Original languageEnglish (US)
Pages (from-to)2877-2894
Number of pages18
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume273
Issue number10
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

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Oropharyngeal Neoplasms
Squamous Cell Carcinoma
Therapeutics
Lymph Nodes
Smoking
History
Drug Therapy
Neoplasms

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Samuels, S. E., Eisbruch, A., Beitler, J. J., Corry, J., Bradford, C. R., Saba, N. F., ... Ferlito, A. (2016). Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we? European Archives of Oto-Rhino-Laryngology, 273(10), 2877-2894. https://doi.org/10.1007/s00405-015-3771-x
Samuels, Stuart E. ; Eisbruch, Avraham ; Beitler, Jonathan J. ; Corry, June ; Bradford, Carol R. ; Saba, Nabil F. ; van den Brekel, Michiel W.M. ; Smee, Robert ; Strojan, Primož ; Suárez, Carlos ; Mendenhall, William M. ; Takes, Robert P. ; Rodrigo, Juan P. ; Haigentz, Missak ; Rapidis, Alexander D. ; Rinaldo, Alessandra ; Ferlito, Alfio. / Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma : where are we?. In: European Archives of Oto-Rhino-Laryngology. 2016 ; Vol. 273, No. 10. pp. 2877-2894.
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abstract = "HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV−) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.",
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Samuels, SE, Eisbruch, A, Beitler, JJ, Corry, J, Bradford, CR, Saba, NF, van den Brekel, MWM, Smee, R, Strojan, P, Suárez, C, Mendenhall, WM, Takes, RP, Rodrigo, JP, Haigentz, M, Rapidis, AD, Rinaldo, A & Ferlito, A 2016, 'Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?', European Archives of Oto-Rhino-Laryngology, vol. 273, no. 10, pp. 2877-2894. https://doi.org/10.1007/s00405-015-3771-x

Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma : where are we? / Samuels, Stuart E.; Eisbruch, Avraham; Beitler, Jonathan J.; Corry, June; Bradford, Carol R.; Saba, Nabil F.; van den Brekel, Michiel W.M.; Smee, Robert; Strojan, Primož; Suárez, Carlos; Mendenhall, William M.; Takes, Robert P.; Rodrigo, Juan P.; Haigentz, Missak; Rapidis, Alexander D.; Rinaldo, Alessandra; Ferlito, Alfio.

In: European Archives of Oto-Rhino-Laryngology, Vol. 273, No. 10, 01.10.2016, p. 2877-2894.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma

T2 - where are we?

AU - Samuels, Stuart E.

AU - Eisbruch, Avraham

AU - Beitler, Jonathan J.

AU - Corry, June

AU - Bradford, Carol R.

AU - Saba, Nabil F.

AU - van den Brekel, Michiel W.M.

AU - Smee, Robert

AU - Strojan, Primož

AU - Suárez, Carlos

AU - Mendenhall, William M.

AU - Takes, Robert P.

AU - Rodrigo, Juan P.

AU - Haigentz, Missak

AU - Rapidis, Alexander D.

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

PY - 2016/10/1

Y1 - 2016/10/1

N2 - HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV−) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.

AB - HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV−) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.

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U2 - 10.1007/s00405-015-3771-x

DO - 10.1007/s00405-015-3771-x

M3 - Review article

C2 - 26463714

AN - SCOPUS:84944556321

VL - 273

SP - 2877

EP - 2894

JO - Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde

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