Lyme neuroborreliosis

Research output: Contribution to journalReview article

Abstract

Purpose of reviewTo review the recent evidence clarifying the symptomatology and diagnosis of nervous system Lyme disease.Recent findingsTwo-tier testing combining pairs of ELISAs, using C6 or VlsE assays to replace second tier Western blots, may eliminate confusion about test interpretation. Cerebrospinal fluid (CSF) can be informative in diagnosing central nervous system (CNS) Lyme disease, not peripheral nervous system (PNS) disorders. CSF CXCL13 may provide useful adjunctive information in CNS infection; its specificity remains to be defined. Lyme encephalopathy is not indicative of CNS infection. Post treatment Lyme disease symptoms do not occur in patients who have had definite CNS Lyme infection. Whether post treatment Lyme disease symptom (PTLDS) is an actual entity, or reflects anchoring bias when commonly occurring symptoms arise in patients previously treated for Lyme disease, remains to be determined. Regardless, these symptoms do not reflect CNS infection and do not respond to additional antimicrobial therapy.SummarySerologic testing is robust in individuals with a priori likelihood of infection of greater than 2-6 weeks duration. Western blots provide useful confirmation of screening ELISAs, but may be replaced by second ELISAs. CSF testing, including CXCL13, may be informative in CNS Lyme, not PNS, and is generally normal in Lyme encephalopathy. PTLDS does not occur following CNS infection, and may not be a distinct entity.

Original languageEnglish (US)
Pages (from-to)259-264
Number of pages6
JournalCurrent opinion in infectious diseases
Volume32
Issue number3
DOIs
StatePublished - Jun 1 2019
Externally publishedYes

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Lyme Neuroborreliosis
Central Nervous System Infections
Lyme Disease
Cerebrospinal Fluid
Enzyme-Linked Immunosorbent Assay
Brain Diseases
Western Blotting
Peripheral Nervous System
Peripheral Nervous System Diseases
Therapeutics
Central Nervous System
Infection

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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abstract = "Purpose of reviewTo review the recent evidence clarifying the symptomatology and diagnosis of nervous system Lyme disease.Recent findingsTwo-tier testing combining pairs of ELISAs, using C6 or VlsE assays to replace second tier Western blots, may eliminate confusion about test interpretation. Cerebrospinal fluid (CSF) can be informative in diagnosing central nervous system (CNS) Lyme disease, not peripheral nervous system (PNS) disorders. CSF CXCL13 may provide useful adjunctive information in CNS infection; its specificity remains to be defined. Lyme encephalopathy is not indicative of CNS infection. Post treatment Lyme disease symptoms do not occur in patients who have had definite CNS Lyme infection. Whether post treatment Lyme disease symptom (PTLDS) is an actual entity, or reflects anchoring bias when commonly occurring symptoms arise in patients previously treated for Lyme disease, remains to be determined. Regardless, these symptoms do not reflect CNS infection and do not respond to additional antimicrobial therapy.SummarySerologic testing is robust in individuals with a priori likelihood of infection of greater than 2-6 weeks duration. Western blots provide useful confirmation of screening ELISAs, but may be replaced by second ELISAs. CSF testing, including CXCL13, may be informative in CNS Lyme, not PNS, and is generally normal in Lyme encephalopathy. PTLDS does not occur following CNS infection, and may not be a distinct entity.",
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Lyme neuroborreliosis. / Halperin, John J.

In: Current opinion in infectious diseases, Vol. 32, No. 3, 01.06.2019, p. 259-264.

Research output: Contribution to journalReview article

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