Abstract
Lyme disease, the multisystem infectious disease caused by the tick-borne spirochete Borrelia burgdorferi, causes a broad variety of peripheral nerve disorders, including single or multiple cranial neuropathies, painful radiculopathies, and diffuse polyneuropathies. Virtually all appear to be varying manifestations of a mononeuropathy multiplex. Diagnosis requires that the patient should have had possible exposure to the only known vectors, Ixodes ticks, and also have either other pathognomonic clinical manifestations or laboratory evidence of exposure. Treatment with antimicrobial regimens is highly effective. The mechanism underlying these neuropathies remains unclear, although interactions between anti-Borrelia antibodies and several peripheral nerve constituent molecules raise intriguing possibilities.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 133-143 |
| Number of pages | 11 |
| Journal | Muscle and Nerve |
| Volume | 28 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 1 2003 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Physiology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Physiology (medical)
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Lyme disease and the peripheral nervous system. / Halperin, John J.
In: Muscle and Nerve, Vol. 28, No. 2, 01.08.2003, p. 133-143.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Lyme disease and the peripheral nervous system
AU - Halperin, John J.
PY - 2003/8/1
Y1 - 2003/8/1
N2 - Lyme disease, the multisystem infectious disease caused by the tick-borne spirochete Borrelia burgdorferi, causes a broad variety of peripheral nerve disorders, including single or multiple cranial neuropathies, painful radiculopathies, and diffuse polyneuropathies. Virtually all appear to be varying manifestations of a mononeuropathy multiplex. Diagnosis requires that the patient should have had possible exposure to the only known vectors, Ixodes ticks, and also have either other pathognomonic clinical manifestations or laboratory evidence of exposure. Treatment with antimicrobial regimens is highly effective. The mechanism underlying these neuropathies remains unclear, although interactions between anti-Borrelia antibodies and several peripheral nerve constituent molecules raise intriguing possibilities.
AB - Lyme disease, the multisystem infectious disease caused by the tick-borne spirochete Borrelia burgdorferi, causes a broad variety of peripheral nerve disorders, including single or multiple cranial neuropathies, painful radiculopathies, and diffuse polyneuropathies. Virtually all appear to be varying manifestations of a mononeuropathy multiplex. Diagnosis requires that the patient should have had possible exposure to the only known vectors, Ixodes ticks, and also have either other pathognomonic clinical manifestations or laboratory evidence of exposure. Treatment with antimicrobial regimens is highly effective. The mechanism underlying these neuropathies remains unclear, although interactions between anti-Borrelia antibodies and several peripheral nerve constituent molecules raise intriguing possibilities.
UR - http://www.scopus.com/inward/record.url?scp=0041766765&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041766765&partnerID=8YFLogxK
U2 - 10.1002/mus.10337
DO - 10.1002/mus.10337
M3 - Review article
C2 - 12872317
AN - SCOPUS:0041766765
VL - 28
SP - 133
EP - 143
JO - Muscle and Nerve
JF - Muscle and Nerve
SN - 0148-639X
IS - 2
ER -