Lyme disease: A multisystem infection that affects the nervous system

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Purpose of Review: This article will enable the reader to diagnose and treat nervous system Lyme disease appropriately.Recent Findings: Appropriately applied serologic testing has high positive and negative predictive values in nervous system Lyme disease. Oral antibiotics can be curative in most cases.Summary: Infection with the tick-transmitted spirochete Borrelia burgdorferi causes Lyme disease, a disorder that involves the nervous system in about 15% of patients. Common manifestations include lymphocytic meningitis, cranial neuritis (particularly cranial nerve VII), painful radiculitis, other forms of mononeuropathy multiplex, and rarely CNS parenchymal involvement. Diagnosis is supported primarily by demonstration of anti-B. burgdorferi antibodies in serum. CSF examination can be informative in problematic cases with parenchymal CNS infection or to identify meningitis. However, oral antibiotics are probably effective in patients with meningitis and other forms of involvement, with the likely exception of parenchymal CNS infection.

Original languageEnglish (US)
Pages (from-to)1338-1350
Number of pages13
JournalCONTINUUM Lifelong Learning in Neurology
Volume18
Issue number6
DOIs
StatePublished - Dec 1 2012

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Lyme Disease
Lyme Neuroborreliosis
Meningitis
Nervous System
Borrelia burgdorferi
Infection
Mononeuropathies
Anti-Bacterial Agents
Neuritis
Spirochaetales
Radiculopathy
Facial Nerve
Ticks
Nervous System Diseases
Antibodies
Serum

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Genetics(clinical)

Cite this

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Lyme disease : A multisystem infection that affects the nervous system. / Halperin, John J.

In: CONTINUUM Lifelong Learning in Neurology, Vol. 18, No. 6, 01.12.2012, p. 1338-1350.

Research output: Contribution to journalReview article

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