Lyme borreliosis-associated encephalopathy

John Halperin, Lauren B. Krupp, Marc G. Golightly, David J. Volkman

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Borrelia burgdorferi infection (Lyme disease) is frequently accompanied by CNS dysfunction. Particularly common is a mild confusional state, the mechanism of which is unknown. Since CNS infection with Bburgdorferi is usually accompanied by intrathecal synthesis of specific antibody, we studied CSF in 73 patients referred for presumed CNS Lyme, manifested primarily as this confusional state. Of 30 seropositive patients evaluated, only 5 had intrathecal antibody production. Seven seronegative patients had positive cell-mediated immune responses to B burgdorferi in the peripheral blood none had antibody production in the CSF. Of the remaining 36 patients referred with this diagnosis despite negative serologic studies, none had compelling evidence of CNS infection by this criterion. We conclude that CNS infection with B burgdorferi does occur in a small proportion of seropositive patients with this confusional state but is extremely uncommon among seronegative individuals with this clinical presentation.

Original languageEnglish (US)
Pages (from-to)1340-1343
Number of pages4
JournalNeurology
Volume40
Issue number9
StatePublished - Jan 1 1990
Externally publishedYes

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Lyme Disease
Brain Diseases
Confusion
Antibody Formation
Infection
Borrelia Infections
Borrelia burgdorferi
Antibodies

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Halperin, J., Krupp, L. B., Golightly, M. G., & Volkman, D. J. (1990). Lyme borreliosis-associated encephalopathy. Neurology, 40(9), 1340-1343.
Halperin, John ; Krupp, Lauren B. ; Golightly, Marc G. ; Volkman, David J. / Lyme borreliosis-associated encephalopathy. In: Neurology. 1990 ; Vol. 40, No. 9. pp. 1340-1343.
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Halperin, J, Krupp, LB, Golightly, MG & Volkman, DJ 1990, 'Lyme borreliosis-associated encephalopathy', Neurology, vol. 40, no. 9, pp. 1340-1343.

Lyme borreliosis-associated encephalopathy. / Halperin, John; Krupp, Lauren B.; Golightly, Marc G.; Volkman, David J.

In: Neurology, Vol. 40, No. 9, 01.01.1990, p. 1340-1343.

Research output: Contribution to journalArticle

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Halperin J, Krupp LB, Golightly MG, Volkman DJ. Lyme borreliosis-associated encephalopathy. Neurology. 1990 Jan 1;40(9):1340-1343.