Low-dose alteplase infusion for the treatment of mechanical aortic valve thrombosis a spotlight on the importance of medication adherence

Manuel Isherwood, Michael Serra, Jordan Safirstein, Neel Shah, Mark Rosenthal

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A rare, yet serious, complication of mechanical heart valves is symptomatic obstructive prosthetic valve thrombosis. The risk of valve thrombosis is magnified in patients who are nonadherent to prescribed anticoagulation. In this case report, we describe a 48-year-old male patient with a history of mechanical aortic valve replacement surgery, who stopped taking prescribed warfarin therapy 2 years before presentation and subsequently developed acute decompensated heart failure secondary to valvular dysfunction. Low-dose alteplase therapy was administered successfully with no bleeding complications and a complete return of valvular function.

Original languageEnglish (US)
Pages (from-to)262-266
Number of pages5
JournalJournal of Cardiovascular Nursing
Volume31
Issue number3
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Medication Adherence
Tissue Plasminogen Activator
Aortic Valve
Thrombosis
Heart Valves
Warfarin
Heart Failure
Hemorrhage
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

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Low-dose alteplase infusion for the treatment of mechanical aortic valve thrombosis a spotlight on the importance of medication adherence. / Isherwood, Manuel; Serra, Michael; Safirstein, Jordan; Shah, Neel; Rosenthal, Mark.

In: Journal of Cardiovascular Nursing, Vol. 31, No. 3, 01.01.2016, p. 262-266.

Research output: Contribution to journalArticle

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