Langerhans cell histiocytosis of the stomach

A cause of granulomatous gastritis and gastric polyposis

G. M. Groisman, Joel Rosh, N. Harpaz

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Langerhans cell histiocytosis (LCH) of the alimentary tract is a rare condition, and LCH of the stomach especially so. We report a histologically and endoscopically unusual case of gastric LCH, the diagnosis of which was based on gastric mucosal biopsy specimens from an adolescent with multi- organ LCH and striking gastric polyposis. Microscopically, the gastric mucosa was expanded by discrete granulomatous microaggregates of Langerhans cells, resulting in a close resemblance to other, more common nonnecrotizing granulomatous gastritides. The diagnosis of LCH was confirmed immunohistochemically and ultrastructurally. To our knowledge, this is the first report of gastric LCH with a granulomatous histologic pattern, and the third to cause diffuse gastric polyposis. Langerhans cell histiocytosis should be included in the histologic differential diagnosis of granulomatous gastritis, as well as in the endoscopic differential diagnosis of gastric polyposis.

Original languageEnglish (US)
Pages (from-to)1232-1235
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume118
Issue number12
StatePublished - Jan 1 1994
Externally publishedYes

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Langerhans Cell Histiocytosis
Gastritis
Stomach
Differential Diagnosis
Langerhans Cells
Gastric Mucosa
Gastric Polyposis
Biopsy

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

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Langerhans cell histiocytosis of the stomach : A cause of granulomatous gastritis and gastric polyposis. / Groisman, G. M.; Rosh, Joel; Harpaz, N.

In: Archives of Pathology and Laboratory Medicine, Vol. 118, No. 12, 01.01.1994, p. 1232-1235.

Research output: Contribution to journalArticle

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AU - Rosh, Joel

AU - Harpaz, N.

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AB - Langerhans cell histiocytosis (LCH) of the alimentary tract is a rare condition, and LCH of the stomach especially so. We report a histologically and endoscopically unusual case of gastric LCH, the diagnosis of which was based on gastric mucosal biopsy specimens from an adolescent with multi- organ LCH and striking gastric polyposis. Microscopically, the gastric mucosa was expanded by discrete granulomatous microaggregates of Langerhans cells, resulting in a close resemblance to other, more common nonnecrotizing granulomatous gastritides. The diagnosis of LCH was confirmed immunohistochemically and ultrastructurally. To our knowledge, this is the first report of gastric LCH with a granulomatous histologic pattern, and the third to cause diffuse gastric polyposis. Langerhans cell histiocytosis should be included in the histologic differential diagnosis of granulomatous gastritis, as well as in the endoscopic differential diagnosis of gastric polyposis.

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