Laboratory values for children with newly diagnosed inflammatory bowel disease

David R. Mack, Christine Langton, James Markowitz, Neal Leleiko, Anne Griffiths, Athos Bousvaros, Jonathan Evans, Subra Kugathasan, Anthony Otley, Mariann Pfefferkorn, Joel Rosh, Adam Mezoff, Susan Moyer, Maria Oliva-Hemker, Robert Rothbaum, Robert Wyllie, J. Fernando DelRosario, David Keljo, Trudy Lerer, Jeffrey Hyams

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

OBJECTIVE. The goal was to determine how often common laboratory tests yield normal results at the time of diagnosis for children with inflammatory bowel disease. METHODS. Data were obtained from a registry of children with newly diagnosed inflammatory bowel disease who were enrolled prospectively in 18 US/Canadian centers. Laboratory values investigated included hemoglobin level, platelet count, albumin level, and erythrocyte sedimentation rate. Disease severity was categorized by physician global assessment. RESULTS. A total of 526 children (mean age: 11.6 years; 58% male; 392 with Crohn disease and 134 with ulcerative colitis) were studied. All 4 values were normal for 21% of patients with mild Crohn disease and 54% with mild ulcerative colitis. In contrast, only 3.8% of children with moderate/severe Crohn disease and 4.3% with moderate/severe ulcerative colitis had normal results for all 4 tests. The erythrocyte sedimentation rate was least likely to be normal; overall, 26% of patients with inflammatory bowel disease had a normal erythrocyte sedimentation rate, including 18% with moderate/severe disease. Hemoglobin levels were normal for 32%, platelet counts for 50%, and albumin levels for 60%. There was no clear association between Crohn disease location and either severity or number of normal laboratory values. In contrast, there were direct correlations between ulcerative colitis disease severity and both the extent of bowel inflammation and the number of abnormal laboratory tests. CONCLUSION. The presence of normal screening laboratory studies should not dissuade clinicians from considering a diagnosis of inflammatory bowel disease.

Original languageEnglish (US)
Pages (from-to)1113-1119
Number of pages7
JournalPediatrics
Volume119
Issue number6
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

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Inflammatory Bowel Diseases
Ulcerative Colitis
Crohn Disease
Blood Sedimentation
Platelet Count
Albumins
Reference Values
Hemoglobins
Registries
Inflammation
Physicians

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Mack, D. R., Langton, C., Markowitz, J., Leleiko, N., Griffiths, A., Bousvaros, A., ... Hyams, J. (2007). Laboratory values for children with newly diagnosed inflammatory bowel disease. Pediatrics, 119(6), 1113-1119. https://doi.org/10.1542/peds.2006-1865
Mack, David R. ; Langton, Christine ; Markowitz, James ; Leleiko, Neal ; Griffiths, Anne ; Bousvaros, Athos ; Evans, Jonathan ; Kugathasan, Subra ; Otley, Anthony ; Pfefferkorn, Mariann ; Rosh, Joel ; Mezoff, Adam ; Moyer, Susan ; Oliva-Hemker, Maria ; Rothbaum, Robert ; Wyllie, Robert ; DelRosario, J. Fernando ; Keljo, David ; Lerer, Trudy ; Hyams, Jeffrey. / Laboratory values for children with newly diagnosed inflammatory bowel disease. In: Pediatrics. 2007 ; Vol. 119, No. 6. pp. 1113-1119.
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abstract = "OBJECTIVE. The goal was to determine how often common laboratory tests yield normal results at the time of diagnosis for children with inflammatory bowel disease. METHODS. Data were obtained from a registry of children with newly diagnosed inflammatory bowel disease who were enrolled prospectively in 18 US/Canadian centers. Laboratory values investigated included hemoglobin level, platelet count, albumin level, and erythrocyte sedimentation rate. Disease severity was categorized by physician global assessment. RESULTS. A total of 526 children (mean age: 11.6 years; 58{\%} male; 392 with Crohn disease and 134 with ulcerative colitis) were studied. All 4 values were normal for 21{\%} of patients with mild Crohn disease and 54{\%} with mild ulcerative colitis. In contrast, only 3.8{\%} of children with moderate/severe Crohn disease and 4.3{\%} with moderate/severe ulcerative colitis had normal results for all 4 tests. The erythrocyte sedimentation rate was least likely to be normal; overall, 26{\%} of patients with inflammatory bowel disease had a normal erythrocyte sedimentation rate, including 18{\%} with moderate/severe disease. Hemoglobin levels were normal for 32{\%}, platelet counts for 50{\%}, and albumin levels for 60{\%}. There was no clear association between Crohn disease location and either severity or number of normal laboratory values. In contrast, there were direct correlations between ulcerative colitis disease severity and both the extent of bowel inflammation and the number of abnormal laboratory tests. CONCLUSION. The presence of normal screening laboratory studies should not dissuade clinicians from considering a diagnosis of inflammatory bowel disease.",
author = "Mack, {David R.} and Christine Langton and James Markowitz and Neal Leleiko and Anne Griffiths and Athos Bousvaros and Jonathan Evans and Subra Kugathasan and Anthony Otley and Mariann Pfefferkorn and Joel Rosh and Adam Mezoff and Susan Moyer and Maria Oliva-Hemker and Robert Rothbaum and Robert Wyllie and DelRosario, {J. Fernando} and David Keljo and Trudy Lerer and Jeffrey Hyams",
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Mack, DR, Langton, C, Markowitz, J, Leleiko, N, Griffiths, A, Bousvaros, A, Evans, J, Kugathasan, S, Otley, A, Pfefferkorn, M, Rosh, J, Mezoff, A, Moyer, S, Oliva-Hemker, M, Rothbaum, R, Wyllie, R, DelRosario, JF, Keljo, D, Lerer, T & Hyams, J 2007, 'Laboratory values for children with newly diagnosed inflammatory bowel disease', Pediatrics, vol. 119, no. 6, pp. 1113-1119. https://doi.org/10.1542/peds.2006-1865

Laboratory values for children with newly diagnosed inflammatory bowel disease. / Mack, David R.; Langton, Christine; Markowitz, James; Leleiko, Neal; Griffiths, Anne; Bousvaros, Athos; Evans, Jonathan; Kugathasan, Subra; Otley, Anthony; Pfefferkorn, Mariann; Rosh, Joel; Mezoff, Adam; Moyer, Susan; Oliva-Hemker, Maria; Rothbaum, Robert; Wyllie, Robert; DelRosario, J. Fernando; Keljo, David; Lerer, Trudy; Hyams, Jeffrey.

In: Pediatrics, Vol. 119, No. 6, 01.06.2007, p. 1113-1119.

Research output: Contribution to journalArticle

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T1 - Laboratory values for children with newly diagnosed inflammatory bowel disease

AU - Mack, David R.

AU - Langton, Christine

AU - Markowitz, James

AU - Leleiko, Neal

AU - Griffiths, Anne

AU - Bousvaros, Athos

AU - Evans, Jonathan

AU - Kugathasan, Subra

AU - Otley, Anthony

AU - Pfefferkorn, Mariann

AU - Rosh, Joel

AU - Mezoff, Adam

AU - Moyer, Susan

AU - Oliva-Hemker, Maria

AU - Rothbaum, Robert

AU - Wyllie, Robert

AU - DelRosario, J. Fernando

AU - Keljo, David

AU - Lerer, Trudy

AU - Hyams, Jeffrey

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N2 - OBJECTIVE. The goal was to determine how often common laboratory tests yield normal results at the time of diagnosis for children with inflammatory bowel disease. METHODS. Data were obtained from a registry of children with newly diagnosed inflammatory bowel disease who were enrolled prospectively in 18 US/Canadian centers. Laboratory values investigated included hemoglobin level, platelet count, albumin level, and erythrocyte sedimentation rate. Disease severity was categorized by physician global assessment. RESULTS. A total of 526 children (mean age: 11.6 years; 58% male; 392 with Crohn disease and 134 with ulcerative colitis) were studied. All 4 values were normal for 21% of patients with mild Crohn disease and 54% with mild ulcerative colitis. In contrast, only 3.8% of children with moderate/severe Crohn disease and 4.3% with moderate/severe ulcerative colitis had normal results for all 4 tests. The erythrocyte sedimentation rate was least likely to be normal; overall, 26% of patients with inflammatory bowel disease had a normal erythrocyte sedimentation rate, including 18% with moderate/severe disease. Hemoglobin levels were normal for 32%, platelet counts for 50%, and albumin levels for 60%. There was no clear association between Crohn disease location and either severity or number of normal laboratory values. In contrast, there were direct correlations between ulcerative colitis disease severity and both the extent of bowel inflammation and the number of abnormal laboratory tests. CONCLUSION. The presence of normal screening laboratory studies should not dissuade clinicians from considering a diagnosis of inflammatory bowel disease.

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Mack DR, Langton C, Markowitz J, Leleiko N, Griffiths A, Bousvaros A et al. Laboratory values for children with newly diagnosed inflammatory bowel disease. Pediatrics. 2007 Jun 1;119(6):1113-1119. https://doi.org/10.1542/peds.2006-1865