Isotonic Tube Feeding Formula Induces Liquid Stool in Normal Subjects

Reversal by Pectina

Donna M. Zimmaro, Rolando Rolandelli, Mark J. Koruda, R. Gregg Settle, T. Peter Stein, John L. Rombeau

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Diarrhea is one of the most common complications in patients who receive tube-feeding formulas. Since the colon is the final site of water and electrolyte absorption and ultimately determines fecal composition, diarrhea during tube feeding may result from altered colonic function. The lack of dietary fiber, such as pectin, in tube-feeding formulas may be one of the means by which colonic function is affected. The purpose of this study was to determine the effect of a standard, liquid, commercially available, isotonic tube-feeding formula (ITFF) and the effects of supplementing the ITFF with pectin on colonic function as measured by stool consistency and colonic fluid composition in 13 normal adults. Data were obtained when subjects consumed their regular diet, ITFF, and ITFF supplemented with pectin using the technique of in vivo dialysis of colonic fluid. Ingestion of the ITFF resulted in a significant increase in the percentage of liquid stools compared to a regular diet [median (interquartile range) = 0% (0), 60% (64);p < 0.01]. Ingestion of the ITFF also resulted in significant decreases in the concentrations of sodium, potassium, and short-chain fatty acids, and increases in pH and osmotic gap in colonic fluid compared to the subjects' regular diet. Supplementing the ITFF with pectin significantly reduced the incidence of liquid stools [0% (0)] and promoted a normalization of colonic fluid composition. The results suggest that the addition of pectin may enhance tolerance to ITFFs.

Original languageEnglish (US)
Pages (from-to)117-123
Number of pages7
JournalJournal of Parenteral and Enteral Nutrition
Volume13
Issue number2
DOIs
StatePublished - Jan 1 1989

Fingerprint

Enteral Nutrition
Diet
Diarrhea
Eating
Volatile Fatty Acids
Dietary Fiber
Electrolytes
Dialysis
Potassium
Colon
Sodium
pectin
Water
Incidence

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Zimmaro, Donna M. ; Rolandelli, Rolando ; Koruda, Mark J. ; Settle, R. Gregg ; Stein, T. Peter ; Rombeau, John L. / Isotonic Tube Feeding Formula Induces Liquid Stool in Normal Subjects : Reversal by Pectina. In: Journal of Parenteral and Enteral Nutrition. 1989 ; Vol. 13, No. 2. pp. 117-123.
@article{a0f9c162609d4072bfbce37a4385f2cb,
title = "Isotonic Tube Feeding Formula Induces Liquid Stool in Normal Subjects: Reversal by Pectina",
abstract = "Diarrhea is one of the most common complications in patients who receive tube-feeding formulas. Since the colon is the final site of water and electrolyte absorption and ultimately determines fecal composition, diarrhea during tube feeding may result from altered colonic function. The lack of dietary fiber, such as pectin, in tube-feeding formulas may be one of the means by which colonic function is affected. The purpose of this study was to determine the effect of a standard, liquid, commercially available, isotonic tube-feeding formula (ITFF) and the effects of supplementing the ITFF with pectin on colonic function as measured by stool consistency and colonic fluid composition in 13 normal adults. Data were obtained when subjects consumed their regular diet, ITFF, and ITFF supplemented with pectin using the technique of in vivo dialysis of colonic fluid. Ingestion of the ITFF resulted in a significant increase in the percentage of liquid stools compared to a regular diet [median (interquartile range) = 0{\%} (0), 60{\%} (64);p < 0.01]. Ingestion of the ITFF also resulted in significant decreases in the concentrations of sodium, potassium, and short-chain fatty acids, and increases in pH and osmotic gap in colonic fluid compared to the subjects' regular diet. Supplementing the ITFF with pectin significantly reduced the incidence of liquid stools [0{\%} (0)] and promoted a normalization of colonic fluid composition. The results suggest that the addition of pectin may enhance tolerance to ITFFs.",
author = "Zimmaro, {Donna M.} and Rolando Rolandelli and Koruda, {Mark J.} and Settle, {R. Gregg} and Stein, {T. Peter} and Rombeau, {John L.}",
year = "1989",
month = "1",
day = "1",
doi = "10.1177/0148607189013002117",
language = "English (US)",
volume = "13",
pages = "117--123",
journal = "Journal of Parenteral and Enteral Nutrition",
issn = "0148-6071",
publisher = "SAGE Publications Inc.",
number = "2",

}

Isotonic Tube Feeding Formula Induces Liquid Stool in Normal Subjects : Reversal by Pectina. / Zimmaro, Donna M.; Rolandelli, Rolando; Koruda, Mark J.; Settle, R. Gregg; Stein, T. Peter; Rombeau, John L.

In: Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 2, 01.01.1989, p. 117-123.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Isotonic Tube Feeding Formula Induces Liquid Stool in Normal Subjects

T2 - Reversal by Pectina

AU - Zimmaro, Donna M.

AU - Rolandelli, Rolando

AU - Koruda, Mark J.

AU - Settle, R. Gregg

AU - Stein, T. Peter

AU - Rombeau, John L.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Diarrhea is one of the most common complications in patients who receive tube-feeding formulas. Since the colon is the final site of water and electrolyte absorption and ultimately determines fecal composition, diarrhea during tube feeding may result from altered colonic function. The lack of dietary fiber, such as pectin, in tube-feeding formulas may be one of the means by which colonic function is affected. The purpose of this study was to determine the effect of a standard, liquid, commercially available, isotonic tube-feeding formula (ITFF) and the effects of supplementing the ITFF with pectin on colonic function as measured by stool consistency and colonic fluid composition in 13 normal adults. Data were obtained when subjects consumed their regular diet, ITFF, and ITFF supplemented with pectin using the technique of in vivo dialysis of colonic fluid. Ingestion of the ITFF resulted in a significant increase in the percentage of liquid stools compared to a regular diet [median (interquartile range) = 0% (0), 60% (64);p < 0.01]. Ingestion of the ITFF also resulted in significant decreases in the concentrations of sodium, potassium, and short-chain fatty acids, and increases in pH and osmotic gap in colonic fluid compared to the subjects' regular diet. Supplementing the ITFF with pectin significantly reduced the incidence of liquid stools [0% (0)] and promoted a normalization of colonic fluid composition. The results suggest that the addition of pectin may enhance tolerance to ITFFs.

AB - Diarrhea is one of the most common complications in patients who receive tube-feeding formulas. Since the colon is the final site of water and electrolyte absorption and ultimately determines fecal composition, diarrhea during tube feeding may result from altered colonic function. The lack of dietary fiber, such as pectin, in tube-feeding formulas may be one of the means by which colonic function is affected. The purpose of this study was to determine the effect of a standard, liquid, commercially available, isotonic tube-feeding formula (ITFF) and the effects of supplementing the ITFF with pectin on colonic function as measured by stool consistency and colonic fluid composition in 13 normal adults. Data were obtained when subjects consumed their regular diet, ITFF, and ITFF supplemented with pectin using the technique of in vivo dialysis of colonic fluid. Ingestion of the ITFF resulted in a significant increase in the percentage of liquid stools compared to a regular diet [median (interquartile range) = 0% (0), 60% (64);p < 0.01]. Ingestion of the ITFF also resulted in significant decreases in the concentrations of sodium, potassium, and short-chain fatty acids, and increases in pH and osmotic gap in colonic fluid compared to the subjects' regular diet. Supplementing the ITFF with pectin significantly reduced the incidence of liquid stools [0% (0)] and promoted a normalization of colonic fluid composition. The results suggest that the addition of pectin may enhance tolerance to ITFFs.

UR - http://www.scopus.com/inward/record.url?scp=0024507993&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024507993&partnerID=8YFLogxK

U2 - 10.1177/0148607189013002117

DO - 10.1177/0148607189013002117

M3 - Article

VL - 13

SP - 117

EP - 123

JO - Journal of Parenteral and Enteral Nutrition

JF - Journal of Parenteral and Enteral Nutrition

SN - 0148-6071

IS - 2

ER -