Is there an association between assisted reproductive technologies and time and complications of the third stage of labor?

Michael Matean Aziz, George Guirguis, Sean Maratto, Carlos Benito, Eric J. Forman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: To determine if vaginal deliveries exposed to assisted reproductive technologies (ART) are associated with an increased time between delivery of the neonate and placenta and select complications. Methods: A retrospective cohort of patients enrolled in an infertility practice who had term, singleton, vaginal deliveries at two academic hospitals from 2008 to 2013 was analyzed. Controls were patients with spontaneous conceptions after infertility consultations. The exposure groups were patients with controlled ovarian hyper-stimulation (COH) with in vivo fertilization, COH with in vitro fertilization and fresh embryo transfer (COH/IVF), and frozen embryo transfer or oocyte donation recipients without COH (non-COH ET). Multiple gestations and stillbirths were excluded. Median time of third stage was compared using the Mann–Whitney U test. Secondary outcomes of retained placenta, manual placental extraction, and post-partum hemorrhage (PPH) were compared using Chi-square or Fisher’s exact analyses. Results: A total of 769 patients met criteria and were analyzed. While there were no differences in time of third stage of labor, retained placenta, or PPH, manual extraction was significantly more common among non-COH ET [age-adjusted OR 5.6 (95 % CI 2.2–13.8); p < 0.001]. Conclusions: Patients who conceived after non-COH ET were at increased risk for manual placental extraction. This association was not influenced by age differences between groups. Further research must be done to determine which elements of the ART process are responsible for these differences.

Original languageEnglish (US)
Pages (from-to)1193-1196
Number of pages4
JournalArchives of Gynecology and Obstetrics
Volume293
Issue number6
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

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Third Labor Stage
Assisted Reproductive Techniques
Ovulation Induction
Retained Placenta
Embryo Transfer
Infertility
Embryo Disposition
Oocyte Donation
Hemorrhage
Stillbirth
Fertilization in Vitro
Fertilization
Placenta
Referral and Consultation
Newborn Infant
Pregnancy

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Aziz, Michael Matean ; Guirguis, George ; Maratto, Sean ; Benito, Carlos ; Forman, Eric J. / Is there an association between assisted reproductive technologies and time and complications of the third stage of labor?. In: Archives of Gynecology and Obstetrics. 2016 ; Vol. 293, No. 6. pp. 1193-1196.
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Is there an association between assisted reproductive technologies and time and complications of the third stage of labor? / Aziz, Michael Matean; Guirguis, George; Maratto, Sean; Benito, Carlos; Forman, Eric J.

In: Archives of Gynecology and Obstetrics, Vol. 293, No. 6, 01.06.2016, p. 1193-1196.

Research output: Contribution to journalArticle

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