Inflammatory bowel disease: How effective is TNF-α suppression?

Wing Cheong Lo, Violeta Arsenescu, Razvan I. Arsenescu, Avner Friedman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Crohn's Disease (CD) results from inappropriate response toward commensal flora. Earlier studies described CD as a Th1 mediated disease. Current models view both phenotypes as a continuum of various permutations between Th1, Th2 and Th17 pathways compounded by a range of Treg disfunctions. In the present paper, we develop a mathematical model, by a system of differential equations, which describe the dynamic relations among these T cells and their cytokines. The model identities four groups of CD patients according to up/down regulation of Th1 and Th2. The model simulations show that immunosuppression by TNF-α blockage benefits the group with Th1High/Th2Low while, by contrast, the group with Th1Low/Th2High will benefit from immune activation.

Original languageEnglish (US)
Article numbere0165782
JournalPLoS ONE
Volume11
Issue number11
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Fingerprint

Crohn disease
inflammatory bowel disease
Inflammatory Bowel Diseases
Crohn Disease
immunosuppression
Immunosuppression
T-cells
simulation models
cytokines
Theoretical Models
Up-Regulation
mathematical models
Down-Regulation
T-lymphocytes
flora
Cytokines
T-Lymphocytes
Phenotype
phenotype
Differential equations

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Lo, Wing Cheong ; Arsenescu, Violeta ; Arsenescu, Razvan I. ; Friedman, Avner. / Inflammatory bowel disease : How effective is TNF-α suppression?. In: PLoS ONE. 2016 ; Vol. 11, No. 11.
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Inflammatory bowel disease : How effective is TNF-α suppression? / Lo, Wing Cheong; Arsenescu, Violeta; Arsenescu, Razvan I.; Friedman, Avner.

In: PLoS ONE, Vol. 11, No. 11, e0165782, 01.11.2016.

Research output: Contribution to journalArticle

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