Inflammatory bowel disease associated with immune thrombocytopenic purpura in children

Leslie M. Higuchi, Steven Joffe, Ellis J. Neufeld, Sally Weisdorf, Joel Rosh, Simon Murch, Attila Devenyi, John F. Thompson, Jeffery D. Lewis, Athos Bousvaros

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Previous reports suggest an association between inflammatory bowel disease (IBD) and immune thrombocytopenic purpura (ITP) in adults. To date, only five children with both diseases have been described. The aim of the study was to describe the characteristics of children with IBD and ITP. Methods: Cases were obtained from the pediatric gastroenterology community by means of the pediatric gastroenterology internet bulletin board in June 1999. Eight cases were submitted from seven medical centers. Medical records were reviewed by two pediatric gastroenterologists and a pediatric hematologist. Results: The age range of the patients was 2.1 to 16.5 years, with a mean age of 9.6 ± 5.2 years. Four children had ulcerative colitis, three had Crohn disease, and one had indeterminate colitis. All had colonic involvement of IBD. Of eight patients, three had IBD first, three had ITP first, and two had both simultaneously. At ITP diagnosis, platelet count was less than 10,000/mL in five children, 17,000/mL in one child, and 50,000 to 60,000/mL in two children. Of the three children diagnosed with ITP first, two initially had rectal bleeding at the time of ITP diagnosis. Bone marrow evaluations, performed in six of eight children, were consistent with ITP. Six of the eight children had chronic IT P, including three children who were 5 years of age or younger. Therapy for ITP included steroids (n = 6), intravenous immunoglobulin (n = 6), Rh(D) intravenous immunoglobulin (n = 2), and splenectomy (n = 1). Conclusions: The authors describe the largest pediatric case series of children with IBD and ITP. More than 50% of the children had the chronic form of ITP. Most patients responded to conventional therapy for ITP and IBD.

Original languageEnglish (US)
Pages (from-to)582-587
Number of pages6
JournalJournal of pediatric gastroenterology and nutrition
Volume33
Issue number5
DOIs
StatePublished - Dec 31 2001
Externally publishedYes

Fingerprint

Idiopathic Thrombocytopenic Purpura
Inflammatory Bowel Diseases
Pediatrics
Intravenous Immunoglobulins
Gastroenterology
Bleeding Time
Splenectomy
Colitis
Platelet Count
Ulcerative Colitis
Crohn Disease
Internet
Medical Records
Bone Marrow
Steroids

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Cite this

Higuchi, Leslie M. ; Joffe, Steven ; Neufeld, Ellis J. ; Weisdorf, Sally ; Rosh, Joel ; Murch, Simon ; Devenyi, Attila ; Thompson, John F. ; Lewis, Jeffery D. ; Bousvaros, Athos. / Inflammatory bowel disease associated with immune thrombocytopenic purpura in children. In: Journal of pediatric gastroenterology and nutrition. 2001 ; Vol. 33, No. 5. pp. 582-587.
@article{2d73abd7cf7a414c8f028f8a84fbab31,
title = "Inflammatory bowel disease associated with immune thrombocytopenic purpura in children",
abstract = "Objective: Previous reports suggest an association between inflammatory bowel disease (IBD) and immune thrombocytopenic purpura (ITP) in adults. To date, only five children with both diseases have been described. The aim of the study was to describe the characteristics of children with IBD and ITP. Methods: Cases were obtained from the pediatric gastroenterology community by means of the pediatric gastroenterology internet bulletin board in June 1999. Eight cases were submitted from seven medical centers. Medical records were reviewed by two pediatric gastroenterologists and a pediatric hematologist. Results: The age range of the patients was 2.1 to 16.5 years, with a mean age of 9.6 ± 5.2 years. Four children had ulcerative colitis, three had Crohn disease, and one had indeterminate colitis. All had colonic involvement of IBD. Of eight patients, three had IBD first, three had ITP first, and two had both simultaneously. At ITP diagnosis, platelet count was less than 10,000/mL in five children, 17,000/mL in one child, and 50,000 to 60,000/mL in two children. Of the three children diagnosed with ITP first, two initially had rectal bleeding at the time of ITP diagnosis. Bone marrow evaluations, performed in six of eight children, were consistent with ITP. Six of the eight children had chronic IT P, including three children who were 5 years of age or younger. Therapy for ITP included steroids (n = 6), intravenous immunoglobulin (n = 6), Rh(D) intravenous immunoglobulin (n = 2), and splenectomy (n = 1). Conclusions: The authors describe the largest pediatric case series of children with IBD and ITP. More than 50{\%} of the children had the chronic form of ITP. Most patients responded to conventional therapy for ITP and IBD.",
author = "Higuchi, {Leslie M.} and Steven Joffe and Neufeld, {Ellis J.} and Sally Weisdorf and Joel Rosh and Simon Murch and Attila Devenyi and Thompson, {John F.} and Lewis, {Jeffery D.} and Athos Bousvaros",
year = "2001",
month = "12",
day = "31",
doi = "10.1097/00005176-200111000-00013",
language = "English (US)",
volume = "33",
pages = "582--587",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

Higuchi, LM, Joffe, S, Neufeld, EJ, Weisdorf, S, Rosh, J, Murch, S, Devenyi, A, Thompson, JF, Lewis, JD & Bousvaros, A 2001, 'Inflammatory bowel disease associated with immune thrombocytopenic purpura in children', Journal of pediatric gastroenterology and nutrition, vol. 33, no. 5, pp. 582-587. https://doi.org/10.1097/00005176-200111000-00013

Inflammatory bowel disease associated with immune thrombocytopenic purpura in children. / Higuchi, Leslie M.; Joffe, Steven; Neufeld, Ellis J.; Weisdorf, Sally; Rosh, Joel; Murch, Simon; Devenyi, Attila; Thompson, John F.; Lewis, Jeffery D.; Bousvaros, Athos.

In: Journal of pediatric gastroenterology and nutrition, Vol. 33, No. 5, 31.12.2001, p. 582-587.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Inflammatory bowel disease associated with immune thrombocytopenic purpura in children

AU - Higuchi, Leslie M.

AU - Joffe, Steven

AU - Neufeld, Ellis J.

AU - Weisdorf, Sally

AU - Rosh, Joel

AU - Murch, Simon

AU - Devenyi, Attila

AU - Thompson, John F.

AU - Lewis, Jeffery D.

AU - Bousvaros, Athos

PY - 2001/12/31

Y1 - 2001/12/31

N2 - Objective: Previous reports suggest an association between inflammatory bowel disease (IBD) and immune thrombocytopenic purpura (ITP) in adults. To date, only five children with both diseases have been described. The aim of the study was to describe the characteristics of children with IBD and ITP. Methods: Cases were obtained from the pediatric gastroenterology community by means of the pediatric gastroenterology internet bulletin board in June 1999. Eight cases were submitted from seven medical centers. Medical records were reviewed by two pediatric gastroenterologists and a pediatric hematologist. Results: The age range of the patients was 2.1 to 16.5 years, with a mean age of 9.6 ± 5.2 years. Four children had ulcerative colitis, three had Crohn disease, and one had indeterminate colitis. All had colonic involvement of IBD. Of eight patients, three had IBD first, three had ITP first, and two had both simultaneously. At ITP diagnosis, platelet count was less than 10,000/mL in five children, 17,000/mL in one child, and 50,000 to 60,000/mL in two children. Of the three children diagnosed with ITP first, two initially had rectal bleeding at the time of ITP diagnosis. Bone marrow evaluations, performed in six of eight children, were consistent with ITP. Six of the eight children had chronic IT P, including three children who were 5 years of age or younger. Therapy for ITP included steroids (n = 6), intravenous immunoglobulin (n = 6), Rh(D) intravenous immunoglobulin (n = 2), and splenectomy (n = 1). Conclusions: The authors describe the largest pediatric case series of children with IBD and ITP. More than 50% of the children had the chronic form of ITP. Most patients responded to conventional therapy for ITP and IBD.

AB - Objective: Previous reports suggest an association between inflammatory bowel disease (IBD) and immune thrombocytopenic purpura (ITP) in adults. To date, only five children with both diseases have been described. The aim of the study was to describe the characteristics of children with IBD and ITP. Methods: Cases were obtained from the pediatric gastroenterology community by means of the pediatric gastroenterology internet bulletin board in June 1999. Eight cases were submitted from seven medical centers. Medical records were reviewed by two pediatric gastroenterologists and a pediatric hematologist. Results: The age range of the patients was 2.1 to 16.5 years, with a mean age of 9.6 ± 5.2 years. Four children had ulcerative colitis, three had Crohn disease, and one had indeterminate colitis. All had colonic involvement of IBD. Of eight patients, three had IBD first, three had ITP first, and two had both simultaneously. At ITP diagnosis, platelet count was less than 10,000/mL in five children, 17,000/mL in one child, and 50,000 to 60,000/mL in two children. Of the three children diagnosed with ITP first, two initially had rectal bleeding at the time of ITP diagnosis. Bone marrow evaluations, performed in six of eight children, were consistent with ITP. Six of the eight children had chronic IT P, including three children who were 5 years of age or younger. Therapy for ITP included steroids (n = 6), intravenous immunoglobulin (n = 6), Rh(D) intravenous immunoglobulin (n = 2), and splenectomy (n = 1). Conclusions: The authors describe the largest pediatric case series of children with IBD and ITP. More than 50% of the children had the chronic form of ITP. Most patients responded to conventional therapy for ITP and IBD.

UR - http://www.scopus.com/inward/record.url?scp=0035215057&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035215057&partnerID=8YFLogxK

U2 - 10.1097/00005176-200111000-00013

DO - 10.1097/00005176-200111000-00013

M3 - Article

VL - 33

SP - 582

EP - 587

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 5

ER -