Abstract
The purpose of this study was to assess the safety and histologic effects of radiofrequency thermal balloon angioplasty in the coronary vasculature of normal pigs. Radiofrequency thermal balloon angioplasty was performed in 30 coronary arteries of 16 nonatheroslerotic pigs. Heated inflations were performed at either 50°, 60°, or 70° C for 30 or 60 seconds, and were compared with five nonheated inflations in five additional arteries. All balloon inflations were performed at 2 atm pressure with a balloon/vessel diameter ratio of 1.2 to 1. Heart rate, arterial pressure, and left ventricular pressure were monitored continuously for each animal. A 12-lead ECG, coronary angiography, and two-dimensional transthoracic echocardiography were performed before and 1 hour after each balloon inflation. Each animal was subsequently put to death for postmortem cardiac examination. Heated inflations were well tolerated in 28 of the 30 arteries without significant adverse effects. During one inflation, ventricular fibrillation occurred because of prolonged ischemia from an occlusive guiding catheter. In another artery, a heated inflation resulted in a dissection with a transient decrease in distal coronary flow. Histologic examination revealed a significant increase in wall thinning and elastic fiber straightening with heating at 70° C for both 30 and 60 seconds, and a significant increase in intracoronary thrombus with heating at 70° C for 60 seconds. Depth of periarterial myocardial heat necrosis paralleled the increase in temperature, with an average depth of 166 μm at 50° C, 312 μm at 60° C, and 1031μm at 70° C. In vivo, radiofrequency coronary angioplasty can be performed relatively safely without significant electrical, hemodynamic, or ischemic changes beyond those seen with conventional nonthermal angioplasty. The extent of heat-induced vessel wall thinning, elastic tissue straightening, intracoronary thrombus formation, and periarterial myocardial necrosis are all related to balloon temperature or duration of heating.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 969-978 |
| Number of pages | 10 |
| Journal | American Heart Journal |
| Volume | 126 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1993 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
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In vivo radiofrequency thermal balloon angioplasty of porcine coronary arteries : Histologic effects and safety. / Fram, Daniel B.; Aretz, Thomas A.; Mikan, Joseph F.; Raisner, Adam; Mitchel, Joseph F.; Gillam, Linda; Waters, David D.; McKay, Raymond G.
In: American Heart Journal, Vol. 126, No. 4, 01.01.1993, p. 969-978.Research output: Contribution to journal › Article
TY - JOUR
T1 - In vivo radiofrequency thermal balloon angioplasty of porcine coronary arteries
T2 - Histologic effects and safety
AU - Fram, Daniel B.
AU - Aretz, Thomas A.
AU - Mikan, Joseph F.
AU - Raisner, Adam
AU - Mitchel, Joseph F.
AU - Gillam, Linda
AU - Waters, David D.
AU - McKay, Raymond G.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - The purpose of this study was to assess the safety and histologic effects of radiofrequency thermal balloon angioplasty in the coronary vasculature of normal pigs. Radiofrequency thermal balloon angioplasty was performed in 30 coronary arteries of 16 nonatheroslerotic pigs. Heated inflations were performed at either 50°, 60°, or 70° C for 30 or 60 seconds, and were compared with five nonheated inflations in five additional arteries. All balloon inflations were performed at 2 atm pressure with a balloon/vessel diameter ratio of 1.2 to 1. Heart rate, arterial pressure, and left ventricular pressure were monitored continuously for each animal. A 12-lead ECG, coronary angiography, and two-dimensional transthoracic echocardiography were performed before and 1 hour after each balloon inflation. Each animal was subsequently put to death for postmortem cardiac examination. Heated inflations were well tolerated in 28 of the 30 arteries without significant adverse effects. During one inflation, ventricular fibrillation occurred because of prolonged ischemia from an occlusive guiding catheter. In another artery, a heated inflation resulted in a dissection with a transient decrease in distal coronary flow. Histologic examination revealed a significant increase in wall thinning and elastic fiber straightening with heating at 70° C for both 30 and 60 seconds, and a significant increase in intracoronary thrombus with heating at 70° C for 60 seconds. Depth of periarterial myocardial heat necrosis paralleled the increase in temperature, with an average depth of 166 μm at 50° C, 312 μm at 60° C, and 1031μm at 70° C. In vivo, radiofrequency coronary angioplasty can be performed relatively safely without significant electrical, hemodynamic, or ischemic changes beyond those seen with conventional nonthermal angioplasty. The extent of heat-induced vessel wall thinning, elastic tissue straightening, intracoronary thrombus formation, and periarterial myocardial necrosis are all related to balloon temperature or duration of heating.
AB - The purpose of this study was to assess the safety and histologic effects of radiofrequency thermal balloon angioplasty in the coronary vasculature of normal pigs. Radiofrequency thermal balloon angioplasty was performed in 30 coronary arteries of 16 nonatheroslerotic pigs. Heated inflations were performed at either 50°, 60°, or 70° C for 30 or 60 seconds, and were compared with five nonheated inflations in five additional arteries. All balloon inflations were performed at 2 atm pressure with a balloon/vessel diameter ratio of 1.2 to 1. Heart rate, arterial pressure, and left ventricular pressure were monitored continuously for each animal. A 12-lead ECG, coronary angiography, and two-dimensional transthoracic echocardiography were performed before and 1 hour after each balloon inflation. Each animal was subsequently put to death for postmortem cardiac examination. Heated inflations were well tolerated in 28 of the 30 arteries without significant adverse effects. During one inflation, ventricular fibrillation occurred because of prolonged ischemia from an occlusive guiding catheter. In another artery, a heated inflation resulted in a dissection with a transient decrease in distal coronary flow. Histologic examination revealed a significant increase in wall thinning and elastic fiber straightening with heating at 70° C for both 30 and 60 seconds, and a significant increase in intracoronary thrombus with heating at 70° C for 60 seconds. Depth of periarterial myocardial heat necrosis paralleled the increase in temperature, with an average depth of 166 μm at 50° C, 312 μm at 60° C, and 1031μm at 70° C. In vivo, radiofrequency coronary angioplasty can be performed relatively safely without significant electrical, hemodynamic, or ischemic changes beyond those seen with conventional nonthermal angioplasty. The extent of heat-induced vessel wall thinning, elastic tissue straightening, intracoronary thrombus formation, and periarterial myocardial necrosis are all related to balloon temperature or duration of heating.
UR - http://www.scopus.com/inward/record.url?scp=0027422426&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027422426&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(93)90714-K
DO - 10.1016/0002-8703(93)90714-K
M3 - Article
C2 - 8213457
AN - SCOPUS:0027422426
VL - 126
SP - 969
EP - 978
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 4
ER -