Hypothesis

The humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis

Elliot Rosenstein, Robert A. Greenwald, Laura J. Kushner, Gerald Weissmann

Research output: Contribution to journalReview article

207 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) and adult periodontitis share common pathogenetic mechanisms and immunologic and pathological findings. One oral pathogen strongly implicated in the pathogenesis of periodontal disease, Porphyromonas gingivalis, possesses a unique microbial enzyme, peptidylarginine deiminase (PAD), the human equivalent of which has been identified as a susceptibility factor for RA. We suggest that individuals predisposed to periodontal infection are exposed to antigens generated by PAD, with deiminated fibrin as a likely candidate, which become systemic immunogens and lead to intraarticular inflammation. PAD engendered antigens lead to production of rheumatoid factor-containing immune complexes and provoke local inflammation, both in gingiva and synovium via Fc and C5a receptors.

Original languageEnglish (US)
Pages (from-to)311-318
Number of pages8
JournalInflammation
Volume28
Issue number6
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

Fingerprint

Humoral Immunity
Rheumatoid Arthritis
Bacteria
Anaphylatoxin C5a Receptor
Inflammation
Antigens
Chronic Periodontitis
Porphyromonas gingivalis
Fc Receptors
Synovial Membrane
Rheumatoid Factor
Gingiva
Periodontal Diseases
Antigen-Antibody Complex
Fibrin
Enzymes
Infection
protein-arginine deiminase

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Immunology
  • Medicine(all)

Cite this

Rosenstein, Elliot ; Greenwald, Robert A. ; Kushner, Laura J. ; Weissmann, Gerald. / Hypothesis : The humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. In: Inflammation. 2004 ; Vol. 28, No. 6. pp. 311-318.
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Hypothesis : The humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. / Rosenstein, Elliot; Greenwald, Robert A.; Kushner, Laura J.; Weissmann, Gerald.

In: Inflammation, Vol. 28, No. 6, 01.12.2004, p. 311-318.

Research output: Contribution to journalReview article

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AU - Rosenstein, Elliot

AU - Greenwald, Robert A.

AU - Kushner, Laura J.

AU - Weissmann, Gerald

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